CA2055435A1 - Cellules eucaryotiques transformees stables comprenant un adn etranger transcriptible sous le controle d'un promoteur pol iii - Google Patents
Cellules eucaryotiques transformees stables comprenant un adn etranger transcriptible sous le controle d'un promoteur pol iiiInfo
- Publication number
- CA2055435A1 CA2055435A1 CA002055435A CA2055435A CA2055435A1 CA 2055435 A1 CA2055435 A1 CA 2055435A1 CA 002055435 A CA002055435 A CA 002055435A CA 2055435 A CA2055435 A CA 2055435A CA 2055435 A1 CA2055435 A1 CA 2055435A1
- Authority
- CA
- Canada
- Prior art keywords
- rna
- retroviral vector
- cell
- stably transformed
- foreign
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35417189A | 1989-05-10 | 1989-05-10 | |
PCT/US1990/002656 WO1990013641A1 (fr) | 1989-05-10 | 1990-05-10 | Cellules eucaryotes transformees de maniere stable comprenant un adn etranger susceptible d'etre transcrit sous la direction d'un promoteur pol iii |
US354,171 | 1994-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2055435A1 true CA2055435A1 (fr) | 1990-11-11 |
Family
ID=23392147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002055435A Abandoned CA2055435A1 (fr) | 1989-05-10 | 1990-05-10 | Cellules eucaryotiques transformees stables comprenant un adn etranger transcriptible sous le controle d'un promoteur pol iii |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0471796A4 (fr) |
JP (1) | JPH04505261A (fr) |
CA (1) | CA2055435A1 (fr) |
WO (1) | WO1990013641A1 (fr) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251675B1 (en) * | 1989-05-25 | 2001-06-26 | Duke University | Methods utilizing mutant rev genes encoding transdominant repressors of HIV replication |
US5871958A (en) * | 1989-05-25 | 1999-02-16 | Duke University | Mutant rev genes encoding transdominant repressors of HIV replication |
DE69233774D1 (de) | 1991-01-21 | 2009-12-10 | Elan Pharm Inc | Prüfung und Modell für Alzheimers-Krankheit |
DE4225094A1 (de) * | 1992-04-28 | 1993-11-04 | Frank Andreas Harald Meyer | Medikament zur gentherapeutischen behandlung von menschen, tieren und pflanzen, insbesondere zur blockierung der virenvermehrung und der tumorgene sowie verfahren zur herstellung des medikaments |
US6469158B1 (en) | 1992-05-14 | 2002-10-22 | Ribozyme Pharmaceuticals, Incorporated | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
US5686599A (en) * | 1992-05-14 | 1997-11-11 | Ribozyme Pharmaceuticals, Inc. | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
US5804683A (en) * | 1992-05-14 | 1998-09-08 | Ribozyme Pharmaceuticals, Inc. | Deprotection of RNA with alkylamine |
US5977343A (en) | 1992-05-14 | 1999-11-02 | Ribozyme Pharmaceuticals, Inc. | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
EP0596901B1 (fr) * | 1992-05-27 | 2000-08-09 | City Of Hope | MOLECULES CHIMERIQUES DE RIBOZYMES D'ARNt LYS |
US5583035A (en) * | 1992-12-07 | 1996-12-10 | Bayer Aktiengesellschaft | HIV antisense expression vectors |
AU5961994A (en) * | 1993-01-22 | 1994-08-15 | University Research Corporation | Localization of therapeutic agents |
US5670361A (en) * | 1993-05-17 | 1997-09-23 | The Regents Of The University Of California | HIV-specific ribozymes |
US6015661A (en) * | 1994-02-14 | 2000-01-18 | The Macfarlane Burnet Centre For Medical Research Limited | Methods for the detection of non-pathogenic HIV-1 strains containing deletions in the Nef coding region and U3 region of the LTR |
CA2183154A1 (fr) * | 1994-02-14 | 1995-08-17 | Nicholas John Deacon | Souches non pathogenes de vih-1 |
US5902880A (en) * | 1994-08-19 | 1999-05-11 | Ribozyme Pharmaceuticals, Inc. | RNA polymerase III-based expression of therapeutic RNAs |
US7083979B1 (en) | 1994-03-25 | 2006-08-01 | Indiana University Foundation | Methods for enhanced retroviral-mediated gene transfer |
WO1995027783A1 (fr) * | 1994-04-06 | 1995-10-19 | Joshi Sukhwal Sadna | Inhibition de la multiplication du vih-1 dans des cellules de mammiferes |
US6146886A (en) | 1994-08-19 | 2000-11-14 | Ribozyme Pharmaceuticals, Inc. | RNA polymerase III-based expression of therapeutic RNAs |
DE69635480T2 (de) | 1995-06-29 | 2006-08-17 | Immunex Corp., Thousand Oaks | Apoptosis induzierendes cytokin |
AU720359B2 (en) | 1995-09-29 | 2000-06-01 | Indiana University Research And Technology Corporation | Methods for enhanced virus-mediated DNA transfer using molecules with virus- and cell-binding domains |
US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
US5955644A (en) * | 1996-08-08 | 1999-09-21 | M.D. Anderson Cancer Center | Ku deficient cells and non-human transgenic animals |
US6057489A (en) * | 1996-09-12 | 2000-05-02 | M.D. Anderson Cancer Center | MmRad51-deficient cells and transgenic mice |
US6384203B1 (en) | 1999-05-12 | 2002-05-07 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) |
EP3112468A1 (fr) | 1998-05-15 | 2017-01-04 | Genentech, Inc. | Polypeptides allogéniques il-17 et utilisations thérapeutiques |
CA2328496C (fr) | 1998-05-15 | 2016-01-05 | Genentech, Inc. | Polypeptides homologues de il-17 et utilisations therapeutiques de ceux-ci |
EP1865061A3 (fr) | 1998-05-15 | 2007-12-19 | Genentech, Inc. | Polypeptides allogéniques IL-17 et utilisations thérapeutiques |
US20020172678A1 (en) | 2000-06-23 | 2002-11-21 | Napoleone Ferrara | EG-VEGF nucleic acids and polypeptides and methods of use |
DE69932247T2 (de) | 1998-08-21 | 2007-05-31 | Immunex Corp., Thousand Oaks | Menschliches il-1 epsilon dna und polypeptide |
EP1978029A3 (fr) | 1999-06-15 | 2008-10-15 | Genentech, Inc. | Polypeptides sécrétés et transmembranaires, et acides nucléiques les codant |
NZ531141A (en) | 1999-10-20 | 2005-07-29 | Genentech Inc | Modulation of T cell differentiation for the treatment of T helper cell mediated diseases |
CA2494705A1 (fr) | 1999-12-01 | 2001-06-07 | Genentech, Inc. | Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides |
EP1897946B1 (fr) | 1999-12-23 | 2012-07-11 | Genentech, Inc. | Polypeptides allogéniques IL-17 et utilisations thérapeutiques |
ATE424457T1 (de) | 2000-01-13 | 2009-03-15 | Genentech Inc | Menschliche stra6 polypeptide |
US6740520B2 (en) | 2000-03-21 | 2004-05-25 | Genentech, Inc. | Cytokine receptor and nucleic acids encoding the same |
CA2403809A1 (fr) | 2000-03-22 | 2001-09-27 | Curagen Corporation | Proteines associees a l'angiogenese et acides nucleiques codant ces proteines |
EP1944317A3 (fr) | 2000-09-01 | 2008-09-17 | Genentech, Inc. | Polypeptides sécrétés et transmembranaires, et acides nucléiques les codant |
WO2002096910A1 (fr) | 2001-05-31 | 2002-12-05 | Medarex, Inc. | Cytotoxines, promedicaments, lieurs et stabilisateurs utiles pour ceux-ci |
US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
CA2633171C (fr) | 2001-06-20 | 2012-11-20 | Genentech, Inc. | Compositions et procedes destines au diagnostic et au traitement de tumeurs |
DE60238143D1 (de) | 2001-09-18 | 2010-12-09 | Genentech Inc | Zusammensetzungen und verfahren für die diagnose von tumoren |
WO2003057160A2 (fr) | 2002-01-02 | 2003-07-17 | Genentech, Inc. | Compositions et methodes de diagnostic et de traitement d'une tumeur |
DK1485477T3 (da) | 2002-02-25 | 2009-08-10 | Genentech Inc | Hidtil ukendt type-1-cytokinreceptor GLM-R |
MXPA04010092A (es) | 2002-04-16 | 2004-12-13 | Genentech Inc | Composiciones y metodos para el diagnostico y tratamiento de tumores. |
US7705195B2 (en) | 2002-06-07 | 2010-04-27 | Genentech, Inc. | Screening method |
EP2277908A3 (fr) | 2003-07-08 | 2011-12-14 | Genentech, Inc. | Polypeptides hétérologues IL-14A/F, anticorps et utilisations thérapeutiques associées |
EP1689432B1 (fr) | 2003-11-17 | 2009-12-30 | Genentech, Inc. | Compositions et methodes de traitement d'une tumeur d'origine hematopoietique |
CN101175769A (zh) | 2005-03-10 | 2008-05-07 | 健泰科生物技术公司 | 用于调控血管完整性的方法和组合物 |
EP1871163A2 (fr) | 2005-06-06 | 2008-01-02 | Genentech, Inc. | Nouvelles interruptions geniques, compositions et methodes associees |
JP2009504183A (ja) | 2005-08-15 | 2009-02-05 | ジェネンテック・インコーポレーテッド | 遺伝子破壊、それに関連する組成物および方法 |
US20080279868A1 (en) | 2005-09-26 | 2008-11-13 | Medarex, Inc. | Antibody-Drug Conjugates and Methods of Use |
CA2630432A1 (fr) | 2005-11-21 | 2007-07-19 | Genentech, Inc. | Nouvelles dissociations de genes, compositions et procedes les concernant |
CA2638821A1 (fr) | 2006-02-17 | 2007-10-11 | Genentech, Inc. | Nouvelles disruption geniques, compositions et procedes associes |
WO2007126455A2 (fr) | 2006-04-05 | 2007-11-08 | Genentech, Inc. | Méthode d'utilisation du boc/cdo pour moduler l'émission des signaux du hedgehog |
EP2082645A1 (fr) | 2006-04-19 | 2009-07-29 | Genentech, Inc. | Nouvelle dislocation de gènes, compositions et procédés correspondants |
JP5588866B2 (ja) | 2007-08-10 | 2014-09-10 | メダレックス エル.エル.シー. | Hco32およびhco27、ならびに関連実施例 |
WO2009102488A2 (fr) | 2008-02-15 | 2009-08-20 | Tufts University | Modèle humanisé de la formation du complexe d’attaque membranaire (mac) sur la rétine murine et compositions, trousses et procédés de traitement de la dégénérescence maculaire |
US8877896B2 (en) | 2008-02-15 | 2014-11-04 | Tufts University | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders |
AU2010289400B2 (en) | 2009-09-02 | 2014-10-23 | Curis, Inc. | Mutant smoothened and methods of using the same |
RU2573896C2 (ru) | 2009-10-15 | 2016-01-27 | Дженентек, Инк. | Химерные факторы роста фибробластов с измененной рецепторной специфичностью |
CA2778442A1 (fr) | 2009-10-22 | 2011-04-28 | Genentech, Inc. | Procedes et compositions pour moduler l'activation d'hepsine d'une proteine de stimulation de macrophage |
CN102741294A (zh) | 2009-11-30 | 2012-10-17 | 霍夫曼-拉罗奇有限公司 | 治疗和诊断表达slc34a2(tat211=seqid2)的肿瘤的抗体 |
PE20130214A1 (es) | 2010-02-23 | 2013-03-11 | Genentech Inc | Composiciones y metodos para el diagnostico y tratamiento de tumores |
MX342239B (es) | 2010-05-03 | 2016-09-21 | Genentech Inc * | Composiciones y metodos para el diagnostico y tratamiento de tumores. |
CA2843684A1 (fr) | 2010-08-13 | 2012-02-16 | Tufts University | Compositions, trousses et methodes de traitement de la degenerescence maculaire au moyen de la proteine cd59 soluble independante de la membrane |
WO2012047968A2 (fr) | 2010-10-05 | 2012-04-12 | Genentech, Inc. | Mutant smoothened et ses procédés d'utilisation |
WO2015116902A1 (fr) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | Récepteurs couplés aux protéines g dans la signalisation hedgehog |
JP6736467B2 (ja) | 2014-02-04 | 2020-08-05 | ジェネンテック, インコーポレイテッド | 平滑化変異体及びその使用方法 |
JP6651506B2 (ja) | 2014-08-28 | 2020-02-19 | タフツ・ユニバーシティ | 補体関連障害を処置するための組成物、方法およびキット |
CA2975875A1 (fr) | 2015-02-04 | 2016-08-11 | Genentech, Inc. | Mutant smoothened et methodes d'utilisation de celui-ci |
WO2017136558A1 (fr) | 2016-02-04 | 2017-08-10 | Curis, Inc. | Mutant smoothened et méthodes d'utilisation dudit mutant |
JP7430394B2 (ja) | 2018-02-12 | 2024-02-13 | トラスティーズ オブ タフツ カレッジ | インフラマソームの活性化を阻害するためのcd59 |
WO2023089564A1 (fr) | 2021-11-19 | 2023-05-25 | Janssen Biotech, Inc. | Méthode de traitement d'une atrophie géographique avec un vecteur de thérapie génique exprimant cd59 soluble |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4497796A (en) * | 1980-03-26 | 1985-02-05 | The Regents Of The University Of California | Gene transfer in intact mammals |
ES2090049T3 (es) * | 1989-03-16 | 1996-10-16 | Boehringer Ingelheim Int | Unidades geneticas para la inhibicion de la funcion de arn. |
-
1990
- 1990-05-10 WO PCT/US1990/002656 patent/WO1990013641A1/fr not_active Application Discontinuation
- 1990-05-10 CA CA002055435A patent/CA2055435A1/fr not_active Abandoned
- 1990-05-10 EP EP19900909233 patent/EP0471796A4/en not_active Withdrawn
- 1990-05-10 JP JP2508724A patent/JPH04505261A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0471796A1 (fr) | 1992-02-26 |
WO1990013641A1 (fr) | 1990-11-15 |
JPH04505261A (ja) | 1992-09-17 |
EP0471796A4 (en) | 1993-05-05 |
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