Die Erfindung betrifft Zubereitungen zur Mund- und Zahnpflege- und -reinigung, die aufgrund von speziellen Inhaltsstoffen ein besonderes Gefühl im Mund bewirken.The invention relates to preparations for oral and dental care and cleaning, which cause a special sensation in the mouth due to special ingredients.
Es ist bekannt, Zubereitungen zur Mund- und Zahnpflege- und -reinigung Geruchs- und/oder Geschmacksstoffe bzw. Aromen zuzusetzen, um ihnen einerseits einen besonderen Geruch bzw. Geschmack zu verleihen und andererseits um ein aromatisches Gefühl von Frische nach der Anwendung zu hinterlassen. Solche Aromen usw. sind im Bereich der Mund- und Zahnpflege und -reinigung weit verbreitet. In speziellen Zubereitungen ist auch der Einsatz von sogenannten Scharfstoffen bereits bekannt, um einen sensorisch interessanten und lang anhaltenden Geschmack und/oder Frischeeffekt zu bewirken. So offenbart die GB 1,438, 205 Zahnpasten oder Mundwässer, welche N-isobutyl-2,6,8-Decatrienamid enthalten, das in Mengen um 0,01 Gew.-%, bezogen auf die Zubereitung, eingesetzt wird.It is known to add preparations for oral and dental care and cleaning odors and / or flavorings or flavors to give them on the one hand a special smell or taste and on the other hand to leave an aromatic feeling of freshness after use. Such flavors etc. are widely used in the oral and dental care and cleaning industries. In special preparations, the use of so-called Scharfstoffen is already known to cause a sensory interesting and long-lasting taste and / or freshness effect. So revealed the GB 1,438, 205 Toothpastes or mouthwashes containing N-isobutyl-2,6,8-decatrienamide, used in amounts of 0.01% by weight, based on the preparation.
Der Einsatz anderer Scharfstoffe aus der Gruppe der Alkadienamide wird beispielsweise in der DE 103 51 422 A1 offenbart.The use of other Scharfstoffe from the group of alkadienamides, for example, in the DE 103 51 422 A1 disclosed.
Es hat sich gezeigt, daß der gewünschte scharfe, kribbelnde, mundwässernde oder wärmeerzeugende Effekt von einem Großteil der Verbraucher als unangenehm und zu stark empfunden wird, das aber die Reduzierung in der Einsatzkonzentration des Scharfstoffes zu verringerter Wahrnehmung des Effektes führt. Es bestand daher nach wie vor der Wunsch nach Zubereitungsformen, die ein sensorisch einzigartiges Empfinden hervorrufen, das vom Verbraucher akzeptiert und nicht als unangenehm empfunden wird.It has been found that the desired sharp, tingling, mouth-watering or heat-generating effect is perceived by a majority of consumers as unpleasant and too strong, but that leads to the reduction in the use concentration of the Scharfstoffes reduced perception of the effect. There was therefore still a desire for forms of preparation that produce a sensory unique sensation that is accepted by the consumer and not perceived as unpleasant.
Überraschenderweise wurde nun festgestellt, daß Zubereitungen, die (einen) mehrwertige(n) Alkohol(e) in bestimmten Mengen und einen scharf schmeckenden und/oder ein Gefühl von Wärme vermittelnden Inhaltsstoff enthalten, dem Anwender ein angenehmes Gefühl von Wärme und Schärfe vermitteln, ohne daß dieses Gefühl als unangenehm empfunden wird.Surprisingly, it has now been found that preparations containing (a) polyhydric alcohol (s) in certain amounts and a sharp-tasting and / or heat-imparting ingredient provide the user with a pleasant feeling of warmth and sharpness, without that this feeling is perceived as unpleasant.
Gegenstand der vorliegenden Erfindung sind demnach Mund- und Zahnpflege- und - reinigungsmittel, enthaltend- bezogen auf ihr Gewicht -
- a) mindestens 40 Gew.-% mindestens eine mehrwertigen Alkohols aus der Gruppe Sorbit und/oder Glycerin und/oder 1,2-Propylenglycol;
- b) mindestens eine scharf schmeckende und/oder ein Gefühl von Wärme erzeugende Substanz.
Accordingly, the present invention relates to mouthwashes, dentifrices and cleaners containing, based on their weight, - a) at least 40 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1,2-propylene glycol;
- b) at least one sharp-tasting and / or a feeling of heat-generating substance.
Mund- und Zahnpflegemittel sowie Mund- und Zahnreinigungsmittel im Sinne der Erfindung sind Mund- und Zahnpulver, Mund- und Zahnpasten, flüssige Mund- und Zahncremes sowie Mund- und Zahngele. Bevorzugt geeignet sind Zahnpasten und flüssige Zahn-reinigungsmittel. Hierzu können die Mund- und Zahnpflege- und reinigungsmittel z.B. in Form von Zahnpasten, flüssigen Zahncremes, Zahnpulvern, Mundwässern oder gegebenenfalls auch als Kaumasse, z. B. als Kaugummi, vorliegen. Bevorzugt liegen sie jedoch als mehr oder weniger fließfähige oder plastische Zahnpasten vor, wie sie zur Reinigung der Zähne unter Einsatz einer Zahnbürste verwendet werden.Oral and dental care products as well as mouth and tooth cleaning agents in the sense of the invention are mouthwashes and toothpowder, oral and toothpastes, liquid mouthwashes and toothpastes as well as oral and dental gels. Preferably, toothpastes and liquid dentifrices are suitable. For this purpose, the oral and dental care and cleaning agents, e.g. in the form of toothpastes, liquid toothpastes, toothpowder, mouthwashes or possibly also as gum, e.g. B. as chewing gum, present. Preferably, however, they are present as more or less flowable or plastic toothpastes, as they are used for cleaning the teeth using a toothbrush.
Die erfindungsgemäßen Mund- und Zahnpflege- und -reinigungsmittel enthalten als ersten wesentlichen Inhaltsstoff mindestens 40 Gew.-% eines mehrwertigen Alkohols aus der Gruppe Sorbit bzw. Glycerin bzw. 1,2-Propylenglycol.The oral and dental care and cleaning compositions according to the invention contain as the first essential ingredient at least 40 wt .-% of a polyhydric alcohol from the group sorbitol or glycerol or 1,2-propylene glycol.
Hier sind erfindungsgemäße Mund- und Zahnpflege- und -reinigungsmittel bevorzugt, die 42,5 bis 70 Gew.-%, vorzugsweise 45 bis 67,5 Gew.-%, besonders bevorzugt 47,5 bis 65 Gew.-% und insbesondere 49 bis 58 Gew.-% mindestens eines mehrwertigen Alkohols aus der Gruppe Sorbit und/oder Glycerin und/oder 1,2-Propylenglycol.-%, jeweils bezogen auf das Gewichts des gesamten Mittels, enthalten.Here, oral and dental care and cleaning agents according to the invention are preferred, which are 42.5 to 70 wt .-%, preferably 45 to 67.5 wt .-%, particularly preferably 47.5 to 65 wt .-% and in particular 49 to 58 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1,2-Propylenglycol .-%, each based on the weight of the total composition.
Neben Sorbit bzw. Glycerin bzw. 1,2-Propylenglycol, von denen mindestens ein Stoff in den erfindungsgemäßen Mitteln enthalten ist, wobei die Gesamtmenge dieser drei Stoffe mindestens 40 Gew.-% (bezogen auf das Mittel) beträgt, eignen sich als weitere mehwertige Alkohole solche mit mindestens 2 OH-Gruppen, vorzugsweise Mannit, Xylitol, Polyethylenglycol, Polypropylenglycol und deren Mischungen.In addition to sorbitol or glycerol or 1,2-propylene glycol, of which at least one substance is contained in the agents according to the invention, the total amount of these three substances being at least 40% by weight (based on the agent), are suitable as further multivalent Alcohols having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof.
Unter diesen Verbindungen sind diejenigen mit 2 bis 12 OH-Gruppen und insbesondere diejenigen mit 2, 3, 4, 5, 6 oder 10 OH-Gruppen bevorzugt.Among these compounds, those having 2 to 12 OH groups, and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.
Polyhydroxyverbindungen mit 2 OH-Gruppen sind beispielsweise Glycol (CH2(OH)CH2OH) und andere 1,2-Diole wie H-(CH2)n-CH(OH)CH2OH mit n = 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Auch 1,3-Diole wie H-(CH2)n-CH(OH) CH2CH2OH mit n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 sind erfindungsgemäß einsetzbar. Die (n,n+1)- bzw. (n,n+2)-Diole mit nicht endständigen OH-Gruppen können ebenfalls eingesetzt werden.Polyhydroxy compounds having 2 OH groups are, for example, glycol (CH 2 (OH) CH 2 OH) and other 1,2-diols such as H- (CH 2 ) n -CH (OH) CH 2 OH where n = 2, 3, 4 , 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Also 1,3-diols such as H- (CH 2 ) n -CH ( OH) CH 2 CH 2 OH with n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 used according to the invention. The (n, n + 1) or (n, n + 2) diols with non-terminal OH groups can also be used.
Wichtige Vertreter von Polyhydroxyverbindungen mit 2 OH-Gruppen sind auch die Polyethylen-und Polypropylenglycole.Important representatives of polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.
Als bevorzugte weitere mehrwertige Alkohole können z. B. Xylit, Propylenglycole, Polyethylenglycole, insbesondere solche mit mittleren Molekulargewichten von 200-800 eingesetzt werden.As preferred further polyhydric alcohols may, for. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.
Besonders bevorzugt ist der Einsatz von Sorbit, so daß Mittel, die außer Sorbit keine anderen mehrwertigen Alkohole enthalten, besonders bevorzugt sind.Particularly preferred is the use of sorbitol, so that agents which contain no other polyhydric alcohols other than sorbitol are particularly preferred.
Üblicherweise enthalten die erfindungsgemäßen Zusammensetzungen Wasser. Hier sind erfindungsgemäße Mund- und Zahnpflege- und -reinigungsmittel bevorzugt, die 20 bis 50 Gew.-%, vorzugsweise 22,5 bis 45 Gew.-%, besonders bevorzugt 25 bis 40 Gew.-% und insbesondere 27,5 bis 37,5 Gew.-% Wasser.-%, jeweils bezogen auf das Gewichts des gesamten Mittels, enthalten.Usually, the compositions of the invention contain water. Here, oral and dental care and cleaning agents according to the invention are preferred which contain from 20 to 50% by weight, preferably from 22.5 to 45% by weight, particularly preferably from 25 to 40% by weight and in particular from 27.5 to 37, 5 wt .-% water .-%, in each case based on the weight of the total composition.
In die Berechnung des Gesamt-Wassergehaltes der Mittel fließen die Wasseranteile wäßriger Lösungen selbstverständlich mit ein. Wird also beispielsweise Sorbit in Form einer 70 Gew.-%-igen Lösung eingesetzt, so beträgt der Sorbit-Anteil das 0,7-fache des eingesetzten Gewichtsanteils, während der Wasseranteil um das 0,3-fache des eingesetzten Gewichtsanteils erhöht wird. Analog ist auch mit wäßrigen Lösungen von Farb- oder Aromastoffen usw. zu verfahren.In the calculation of the total water content of the funds, the water content of aqueous solutions of course with a. If, for example, sorbitol is used in the form of a 70% strength by weight solution, the sorbitol content is 0.7 times the weight fraction used, while the water content is increased by 0.3 times the weight fraction used. The same procedure is to be followed with aqueous solutions of colorants or flavorings, etc.
Als zweiten wesentlichen Inhaltsstoff enthalten die erfindungsgemäßen Mund- und Zahnpflege-und -reinigungsmittel eine scharf schmeckende und/oder ein Gefühl von Wärme erzeugende Substanz. Diese Substanzen vermitteln dem Anwender einen scharfen, kribbelnden, mundwässernden oder wärmeerzeugenden Effekt, d.h. sie rufen sensorisch einen Wärmeeindruck oder ein Brennen, oder ein Prickeln, Perlen, Kitzeln oder Sprudeln hervor.As a second essential ingredient, the oral and dental care and cleaning compositions of the invention contain a pungent-tasting and / or a feeling of heat-generating substance. These substances give the user a sharp, tingling, mouthwashing or heat generating effect, i. they cause a sensation of warmth or burning, or tingling, beads, tickling or bubbling.
Erfindungsgemäß bevorzugte Mund- und Zahnpflege- und -reinigungsmittel enthalten die scharf schmeckende(n) und/oder ein Gefühl von Wärme erzeugende(n) Substanz(en) in Mengen von 0,00001 bis 5 Gew.-%, vorzugsweise von 0,0005 bis 2,5 Gew.-%, weiter bevorzugt von 0,001 bis 1 Gew.-%, besonders bevorzugt von 0,005 bis 0,5 Gew.-% und insbesondere von 0,01 bis 0,2 Gew.-%, jeweils bezogen auf das Gewichts des gesamten Mittels.Oral and dental care and cleaning agents which are preferred according to the invention contain the pungent-tasting and / or a feeling of heat-generating substance (s) in amounts of from 0.00001 to 5% by weight, preferably of 0.0005 to 2.5 wt .-%, more preferably from 0.001 to 1 wt .-%, particularly preferably from 0.005 to 0.5 wt .-% and in particular from 0.01 to 0.2 wt .-%, each based on the weight of the entire agent.
Als scharf schmeckende oder ein Gefühl von Wärme erzeugende Substanz kann eine Reihe von Stoffen eingesetzt werden. Bevorzugt sind insbesondere N-Alkyl-substituierte Amide von ungesättigten Carbonsäuren, beispielsweise
- 2E,4E-Decadiensäure-N-Methylamid
- 2E,4E-Decadiensäure-N-Ethylamid
- 2E,4E-Decadiensäure-N-n-Propylamid
- 2E,4E-Decadiensäure-N-Isopropylamid
- 2E,4E-Decadiensäure-N-n-Butylamid
- 2E,4E-Decadiensäure-N-(1-Methylpropyl)-amid
- 2E,4E-Decadiensäure-N-Isobutylamid
- 2E,4E-Decadiensäure-N-tert-Butylamid
- 2E,4Z-Decadiensäure-N-Methylamid
- 2E,4Z-Decadiensäure-N-Ethylamid
- 2E,4Z-Decadiensäure-N-n-Propylamid
- 2E,4Z-Decadiensäure-N-Isopropylamid
- 2E,4Z-Decadiensäure-N-n-Butylamid
- 2E,4Z-Decadiensäure-N-(1-Methylpropyl)-amid
- 2E,4Z-Decadiensäure-N-Isobutylamid
- 2E,4Z-Decadiensäure-N-tert-Butylamid
- 2E,4E,8Z-Decatriensäure-N-Methylamid
- 2E,4E,8Z-Decatriensäure-N-Ethylamid
- 2E,4E,8Z-Decatriensäure-N-n-Propylamid
- 2E,4E,8Z-Decatriensäure-N-Isopropylamid
- 2E,4E,8Z-Decatriensäure-N-n-Butylamid
- 2E,4E,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,4E,8Z-Decatriensäure-N-Isobutylamid
- 2E,4E,8Z-Decatriensäure-N-tert-Butylamid
- 2E,4Z,8Z-Decatriensäure-N-Methylamid
- 2E,4Z,8Z-Decatriensäure-N-Ethylamid
- 2E,4Z,8Z-Decatriensäure-N-n-Propylamid
- 2E,4Z,8Z-Decatriensäure-N-Isopropylamid
- 2E,4Z,8Z-Decatriensäure-N-n-Butylamid
- 2E,4Z,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,4Z,8Z-Decatriensäure-N-Isobutylamid
- 2E,4Z,8Z-Decatriensäure-N-tert-Butylamid
- 2E,4E,8E-Decatriensäure-N-Methylamid
- 2E,4E,8E-Decatriensäure-N-Ethylamid
- 2E,4E,8E-Decatriensäure-N-n-Propylamid
- 2E,4E,8E-Decatriensäure-N-Isopropylamid
- 2E,4E,8E-Decatriensäure-N-n-Butylamid
- 2E,4E,8E-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,4E,8E-Decatriensäure-N-Isobutylamid
- 2E,4E,8E-Decatriensäure-N-tert-Butylamid
- 2E,4Z,8E-Decatriensäure-N-Methylamid
- 2E,4Z,8E-Decatriensäure-N-Ethylamid
- 2E,4Z,8E-Decatriensäure-N-n-Propylamid
- 2E,4Z,8E-Decatriensäure-N-Isopropylamid
- 2E,4Z,8E-Decatriensäure-N-n-Butylamid
- 2E,4Z,8E-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,4Z,8E-Decatriensäure-N-Isobutylamid
- 2E,4Z,8E-Decatriensäure-N-tert-Butylamid
- 2E,6Z,8E-Decatriensäure-N-Methylamid
- 2E,6Z,8E-Decatriensäure-N-Ethylamid
- 2E,6Z,8E-Decatriensäure-N-n-Propylamid
- 2E,6Z,8E-Decatriensäure-N-Isopropylamid
- 2E,6Z,8E-Decatriensäure-N-n-Butylamid
- 2E,6Z,8E-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,6Z,8E-Decatriensäure-N-Isobutylamid
- 2E,6Z,8E-Decatriensäure-N-tert-Butylamid
- 2E,6E,8E-Decatriensäure-N-Methylamid
- 2E,6E,8E-Decatriensäure-N-Ethylamid
- 2E,6E,8E-Decatriensäure-N-n-Propylamid
- 2E,6E,8E-Decatriensäure-N-Isopropylamid
- 2E,6E,8E-Decatriensäure-N-n-Butylamid
- 2E,6E,8E-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,6E,8E-Decatriensäure-N-Isobutylamid
- 2E,6E,8E-Decatriensäure-N-tert-Butylamid
- 2E,6Z,8Z-Decatriensäure-N-Methylamid
- 2E,6Z,8Z-Decatriensäure-N-Ethylamid
- 2E,6Z,8Z-Decatriensäure-N-n-Propylamid
- 2E,6Z,8Z-Decatriensäure-N-Isopropylamid
- 2E,6Z,8Z-Decatriensäure-N-n-Butylamid
- 2E,6Z,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,6Z,8Z-Decatriensäure-N-Isobutylamid
- 2E,6Z,8Z-Decatriensäure-N-tert-Butylamid
- 2E,6E,8Z-Decatriensäure-N-Methylamid
- 2E,6E,8Z-Decatriensäure-N-Ethylamid
- 2E,6E,8Z-Decatriensäure-N-n-Propylamid
- 2E,6E,8Z-Decatriensäure-N-Isopropylamid
- 2E,6E,8Z-Decatriensäure-N-n-Butylamid
- 2E,6E,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
- 2E,6E,8Z-Decatriensäure-N-Isobutylamid
- 2E,6E,8Z-Decatriensäure-N-tert-Butylamid
- 2E,7Z,9E-Undecatriensäure -N-Methylamid
- 2E,7Z,9E-Undecatriensäure -N-Ethylamid
- 2E,7Z,9E-Undecatriensäure -N-n-Propylamid
- 2E,7Z,9E-Undecatriensäure -N-Isopropylamid
- 2E,7Z,9E-Undecatriensäure -N-n-Butylamid
- 2E,7Z,9E-Undecatriensäure -N-(1-Methylpropyl)-amid
- 2E,7Z,9E-Undecatriensäure-N-isobutylamid
- 2E,7Z,9E-Undecatriensäure -N-tert-Butylamid
- 2E,7E,9E-Undecatriensäure -N-Methylamid
- 2E,7E,9E-Undecatriensäure -N-Ethylamid
- 2E,7E,9E-Undecatriensäure -N-n-Propylamid
- 2E,7E,9E-Undecatriensäure -N-Isopropylamid
- 2E,7E,9E-Undecatriensäure -N-n-Butylamid
- 2E,7E,9E-Undecatriensäure -N-(1 -Methylpropyl)-amid
- 2E,7E,9E-Undecatriensäure-N-isobutylamid
- 2E,7E,9E-Undecatriensäure -N-tert-Butylamid
- 2E,7Z,9Z-Undecatriensäure -N-Methylamid
- 2E,7Z,9Z-Undecatriensäure -N-Ethylamid
- 2E,7Z,9Z-Undecatriensäure -N-n-Propylamid
- 2E,7Z,9Z-Undecatriensäure -N-Isopropylamid
- 2E,7Z,9Z-Undecatriensäure -N-n-Butylamid
- 2E,7Z,9Z-Undecatriensäure -N-(1-Methylpropyl)-amid
- 2E,7Z,9Z-Undecatriensäure-N-isobutylamid
- 2E,7Z,9Z-Undecatriensäure -N-tert-Butylamid
- 2E,7Z,9E-Undecatriensäure -N-Methylamid
- 2E,7Z,9E-Undecatriensäure -N-Ethylamid
- 2E,7Z,9E-Undecatriensäure -N-n-Propylamid
- 2E,7Z,9E-Undecatriensäure -N-Isopropylamid
- 2E,7Z,9E-Undecatriensäure -N-n-Butylamid
- 2E,7Z,9E-Undecatriensäure -N-(1-Methylpropyl)-amid
- 2E,7Z,9E-Undecatriensäure-N-isobutylamid
- 2E,7Z,9E-Undecatriensäure -N-tert-Butylamid
As a pungent or a feeling of heat generating substance, a number of substances can be used. Preference is given in particular to N-alkyl-substituted amides of unsaturated carboxylic acids, for example - 2E, 4E-decadienoic-N-methyl amide
- 2E, 4E-decadienoic-N-ethyl amide
- 2E, 4E-decadienoic-Nn-propylamide
- 2E, 4E-decadienoic-N-isopropylamide
- 2E, 4E-decadienoic-Nn-butylamide
- 2E, 4E-decadienoic acid-N- (1-methylpropyl) -amide
- 2E, 4E-decadienoic-N-isobutylamide
- 2E, 4E-decadienoic acid-N-tert-butylamide
- 2E, 4Z-decadienoic-N-methyl amide
- 2E, 4Z-decadienoic-N-ethyl amide
- 2E, 4Z-decadienoic-Nn-propylamide
- 2E, 4Z-decadienoic-N-isopropylamide
- 2E, 4Z-decadienoic-Nn-butylamide
- 2E, 4Z-decadienoic acid-N- (1-methylpropyl) -amide
- 2E, 4Z-decadienoic-N-isobutylamide
- 2E, 4Z-decadienoic acid-N-tert-butylamide
- 2E, 4E, 8Z-Decatriensäure-N-methyl amide
- 2E, 4E, 8Z-Decatriensäure-N-ethyl amide
- 2E, 4E, 8Z-Decatriensäure-Nn-propylamide
- 2E, 4E, 8Z-Decatriensäure-N-isopropylamide
- 2E, 4E, 8Z-Decatriensäure-Nn-butylamide
- 2E, 4E, 8Z-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 4E, 8Z-Decatriensäure-N-isobutylamide
- 2E, 4E, 8Z-Decatriensäure-N-tert-butylamide
- 2E, 4Z, 8Z-Decatriensäure-N-methyl amide
- 2E, 4Z, 8Z-Decatriensäure-N-ethyl amide
- 2E, 4Z, 8Z-Decatriensäure-Nn-propylamide
- 2E, 4Z, 8Z-Decatriensäure-N-isopropylamide
- 2E, 4Z, 8Z-Decatriensäure-Nn-butylamide
- 2E, 4Z, 8Z-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 4Z, 8Z-Decatriensäure-N-isobutylamide
- 2E, 4Z, 8Z-Decatriensäure-N-tert-butylamide
- 2E, 4E, 8E-Decatriensäure-N-methyl amide
- 2E, 4E, 8E-Decatriensäure-N-ethyl amide
- 2E, 4E, 8E-Decatriensäure-Nn-propylamide
- 2E, 4E, 8E-Decatriensäure-N-isopropylamide
- 2E, 4E, 8E-Decatriensäure-Nn-butylamide
- 2E, 4E, 8E-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 4E, 8E-Decatriensäure-N-isobutylamide
- 2E, 4E, 8E-Decatriensäure-N-tert-butylamide
- 2E, 4Z, 8E-Decatriensäure-N-methyl amide
- 2E, 4Z, 8E-Decatriensäure-N-ethyl amide
- 2E, 4Z, 8E-Decatriensäure-Nn-propylamide
- 2E, 4Z, 8E-Decatriensäure-N-isopropylamide
- 2E, 4Z, 8E-Decatriensäure-Nn-butylamide
- 2E, 4Z, 8E-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 4Z, 8E-Decatriensäure N isobutylamide
- 2E, 4Z, 8E-Decatriensäure-N-tert-butylamide
- 2E, 6Z, 8E-Decatriensäure-N-methyl amide
- 2E, 6Z, 8E-Decatriensäure-N-ethyl amide
- 2E, 6Z, 8E-Decatriensäure-Nn-propylamide
- 2E, 6Z, 8E-Decatriensäure-N-isopropylamide
- 2E, 6Z, 8E-Decatriensäure-Nn-butylamide
- 2E, 6Z, 8E-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 6Z, 8E-Decatriensäure-N-isobutylamide
- 2E, 6Z, 8E-Decatriensäure-N-tert-butylamide
- 2E, 6E, 8E-Decatriensäure-N-methyl amide
- 2E, 6E, 8E-Decatriensäure-N-ethyl amide
- 2E, 6E, 8E-Decatriensäure-Nn-propylamide
- 2E, 6E, 8E-Decatriensäure-N-isopropylamide
- 2E, 6E, 8E-Decatriensäure-Nn-butylamide
- 2E, 6E, 8E-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 6E, 8E-Decatriensäure-N-isobutylamide
- 2E, 6E, 8E-Decatriensäure-N-tert-butylamide
- 2E, 6Z, 8Z-Decatriensäure-N-methyl amide
- 2E, 6Z, 8Z-Decatriensäure-N-ethyl amide
- 2E, 6Z, 8Z-Decatriensäure-Nn-propylamide
- 2E, 6Z, 8Z-Decatriensäure-N-isopropylamide
- 2E, 6Z, 8Z-Decatriensäure-Nn-butylamide
- 2E, 6Z, 8Z-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 6Z, 8Z-Decatriensäure-N-isobutylamide
- 2E, 6Z, 8Z-Decatriensäure-N-tert-butylamide
- 2E, 6E, 8Z-Decatriensäure-N-methyl amide
- 2E, 6E, 8Z-Decatriensäure-N-ethyl amide
- 2E, 6E, 8Z-Decatriensäure-Nn-propylamide
- 2E, 6E, 8Z-Decatriensäure-N-isopropylamide
- 2E, 6E, 8Z-Decatriensäure-Nn-butylamide
- 2E, 6E, 8Z-Decatriensäure-N- (1-methylpropyl) -amide
- 2E, 6E, 8Z-Decatriensäure-N-isobutylamide
- 2E, 6E, 8Z-Decatriensäure-N-tert-butylamide
- 2E, 7Z, 9E-undecatrienoic acid-N-methylamide
- 2E, 7Z, 9E-undecatrienoic acid-N-ethylamide
- 2E, 7Z, 9E-undecatrienoic acid -n-propylamide
- 2E, 7Z, 9E-undecatrienoic acid -N-isopropylamide
- 2E, 7Z, 9E-undecatrienoic acid -n-butylamide
- 2E, 7Z, 9E-undecatrienoic acid-N- (1-methylpropyl) -amide
- 2E, 7Z, 9E-Undecatriensäure-N-isobutylamide
- 2E, 7Z, 9E-undecatrienoic acid-N-tert-butylamide
- 2E, 7E, 9E-undecatrienoic acid-N-methylamide
- 2E, 7E, 9E-undecatrienoic acid-N-ethylamide
- 2E, 7E, 9E-undecatrienoic acid -n-propylamide
- 2E, 7E, 9E-undecatrienoic acid -N-isopropylamide
- 2E, 7E, 9E-undecatrienoic acid -n-butyl-amide
- 2E, 7E, 9E-undecatrienoic acid-N- (1-methylpropyl) -amide
- 2E, 7E, 9E-Undecatriensäure-N-isobutylamide
- 2E, 7E, 9E-undecatrienoic acid -N-tert-butylamide
- 2E, 7Z, 9Z-undecatrienoic acid-N-methylamide
- 2E, 7Z, 9Z-undecatrienoic acid-N-ethylamide
- 2E, 7Z, 9Z-undecatrienoic acid -n-propylamide
- 2E, 7Z, 9Z-undecatrienoic acid-N-isopropylamide
- 2E, 7Z, 9Z-undecatrienoic acid -Nn-butylamide
- 2E, 7Z, 9Z-undecatrienoic acid-N- (1-methylpropyl) -amide
- 2E, 7Z, 9Z-Undecatriensäure-N-isobutylamide
- 2E, 7Z, 9Z-undecatrienoic acid -N-tert-butylamide
- 2E, 7Z, 9E-undecatrienoic acid-N-methylamide
- 2E, 7Z, 9E-undecatrienoic acid-N-ethylamide
- 2E, 7Z, 9E-undecatrienoic acid -n-propylamide
- 2E, 7Z, 9E-undecatrienoic acid -N-isopropylamide
- 2E, 7Z, 9E-undecatrienoic acid -n-butylamide
- 2E, 7Z, 9E-undecatrienoic acid-N- (1-methylpropyl) -amide
- 2E, 7Z, 9E-Undecatriensäure-N-isobutylamide
- 2E, 7Z, 9E-undecatrienoic acid-N-tert-butylamide
Selbstverständlich sind auch andere Substitutionsmuster am Stickstoffatom möglich und bevorzugt, beispielsweise längerkettige n-Alkylreste (...-N-n-Pentylamid, ...-N-n-Pentylamid, ...-N-n-Pentylamid, ...-N-n-Pentylamid, ...-N-n-Pentylamid, ...-N-n-Hexylamid, ...-N-n-Heptylamid, ...-N-n-Octylamid, ...-N-n-Nonylamid, ...-N-n-Decylamid, ...-N-n-Undecylamid, ...-N-n-Dodecylamid, ...-N-n-Tridecylamid, usw.) oder disubstituierte ...-N,N-Dialkylamide wie ...-N,N-dimethylamid, ...-N,N-diethylamid, ...-N,N-di-n-propylamid, ...-N,N-düsopropylamid, ...-N,N-di-n-butylamid, ...-N,N-di(1-Methylpropyl)amid, ...-N,N-diisobutylamid, ...-N,N-di-tert-butylamid, ...-N,N-methyl-ethylamid, ...-N,N-methyl-n-propylamid, ...-N,N-methyl-isopropylamid, ...-N,N-ethyl-n-propylamid, ...-N,N-ethyl-isopropylamid, usw..Of course, other substitution patterns on the nitrogen atom are possible and preferred, for example, longer-chain n-alkyl radicals (... Nn-Pentylamid, ... Nn-pentylamide, ... Nn-pentylamide, ... Nn-pentylamide,. ..- Nn-pentylamide, ...- Nn-hexylamide, ...- Nn-heptylamide, ...- Nn-octylamide, ...- Nn-nonylamide, ...- Nn-decylamide, ... -Nn-undecylamide, ... -Nn-dodecylamide, ... -Nn-tridecylamide, etc.) or disubstituted... N, N-dialkylamides such as... N, N-dimethylamide,... N, N-diethylamide,... N, N-di-n-propylamide,... N, N-diisopropylamide,... N, N-di-n-butylamide,... N-di (1-methylpropyl) amide,... N, N-diisobutylamide,... N, N-di-tert-butylamide,... N, N-methyl-ethylamide,... N, N-methyl-n-propylamide, N, N-methyl-isopropylamide, N, N-ethyl-n-propylamide, N, N-ethyl-isopropylamide, etc. ,
Unter den genannten Verbindungen sind einige im Rahmen der vorliegenden Erfindung besonders bevorzugt. Diese sind nachfolgend aufgeführt:Among the compounds mentioned, some are particularly preferred in the context of the present invention. These are listed below:
2E,6Z,8E-Decatriensäure-N-isobutylamid (N-Isobutyl-2E,6Z,8E-decatrienamid, auch Spilanthol oder Affinin genannt):
2E, 6Z, 8E-decatrienoic acid N-isobutylamide (N-isobutyl-2E, 6Z, 8E-decatrienamide, also called spilanthol or affinin):
2E,4E,8Z-Decatriensäure-N-isobutylamid (N-Isobutyl-2E,4E,8Z-decatrienamid, auch Isoaffinin genannt):
2E, 4E, 8Z-Decatrienoic acid N-isobutylamide (N-isobutyl-2E, 4E, 8Z-decatrienamide, also called isoaffinin):
2E,7Z,9E-Undecatriensäure-N-isobutylamid (N-Isobutyl-2E,7Z,9E-undecatrienamid):
2E, 7Z, 9E-undecatrienoic acid N-isobutylamide (N-isobutyl-2E, 7Z, 9E-undecatrienamide):
2E,4Z-Decadiensäure-N-isobutylamid (cis-Pellitorin):
2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin):
2E,4E-Decadiensäure-N-isobutylamid (trans-Pellitorin):
2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin):
Ferulasäureamide, beispielsweiseFerulic acid amides, for example
Ferulasäure-N-Vanillylamid:
Ferulic acid N vanillylamide:
N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)- (2E)-propensäureamid (trans-Feruloylmethoxytyramin):
N - [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2 E ) -propenoic acid amide (trans -feruloylmethoxytyramine):
N-[2- (4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2 Z)-propensäureamid (cis-Feruloylmethoxytyramin): N- [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2 Z) -propenoic acid amide (cis-feruloylmethoxytyramine):
N-[2-(4- Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)- propansäureamid (Dihydroferuloylmethoxytyramin):
N - [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) propanoic acid amide (dihydroferuloylmethoxytyramine):
N-[2-(3,4- Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)- propensäureamid (trans-Feruloyldopamin):
N - [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2 E ) - propenoic acid amide (trans -feruloyldopamine):
N-[2-(3,4-Dihydroxyphenyl) ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloyldopamin):
N - [2- (3,4-dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxy-phenyl) - (2 Z) -propenoic acid amide (cis-Feruloyldopamin):
N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4- dihydroxyphenyl)-(2E)-propensäureamid (trans-Caffeoyltyramin):
N - [2- (4-Hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2 E ) -propenoic acid amide (trans-caffeoyltyramine):
N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2Z)- propensäureamid (cis-Caffeoyltyramin):
N - [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2 Z) - propenoic (cis-Caffeoyltyramin):
N-[2-(3,4-Dimethoxyphenyl) ethyl]-3-(3,4-dimethoxyphenyl)-(2E)-propensäureamid (trans-Rubenamin):
N - [2- (3,4-Dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2 E ) -propenoic acid amide (trans-Rubenamine):
N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(3,4- dimethoxy-phenyl)-(2Z)-propensäureamid (cis-Rubenamin):
Weitere im Rahmen der vorliegenden Erfindung mit besonderem Vorzug einsetzbare Scharfstoffe sind beispielsweise Extrakte aus Naturpflanzen. Scharf schmeckende pflanzliche Extrakte können alle physiologisch unbedenklichen pflanzlichen Extrakte sein, die einen scharfen oder warmen sensorischen Eindruck hervorrufen. Bevorzugt als scharf schmeckende pflanzliche Extrakte sind beispielsweise Pfefferextrakt (Piper ssp., insbesondere Piper nigrum), Wasserpfefferextrakt (Polygonum ssp. ,insbesondere Polygonum hydropiper), Extrakte aus Allium ssp.(insbesondere Zwiebel und Knoblauchextrakte), Extrakte aus Rettich (Raphanus ssp.), Meerrettichextrakte (Cochlearia armoracia), Extrakte aus schwarzem (Brassica nigra), wildem oder gelbem Senf (Sinapis ssp., insbesondere Sinapis arvensis und Sinapis alba), Bertramwurzel-Extrakte (Anacyclus ssp., insbesondere Anacyclus pyrethrumL.), Sonnenhutextrakte ( Echinaceae ssp.), Extrakten aus Szechuan-Pfeffer (Zanthoxylum ssp., insbesondere Zanthoxylum piperitum), Spilanthesextrakt (Spilanthes ssp., insbesondere Spilanthes acmella), Chiliextrakt (Capsicum ssp., insbesondere Capsicum frutescens ), Paradieskörner-Extrakt ( Aframomum ssp.,insbesondere Aframomum melegueta[Rose] K. Schum.),Ingwerextrakt (Zingiber ssp.,insbesondere Zingiber officinale) und Galangaextrakt (Kaempferia galanga oder Alpinia galanga). N - [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2 Z) -propenoic acid amide (cis-Ruben amine): Other useful in the context of the present invention Scharfstoffe are, for example, extracts of natural plants. Hot-tasting herbal extracts can be any physiologically harmless herbal extract that produces a sharp or warm sensory impression. Pepper extract (Piper ssp., In particular Piper nigrum), water pepper extract (Polygonum spp. , In particular Polygonum hydropiper), extracts of Allium ssp . (In particular onion and garlic extracts), extracts of radish (Raphanus ssp.) Are preferred as pungent-tasting plant extracts . , Horseradish extracts ( Cochlearia armoracia), extracts of black (Brassica nigra), wild or yellow mustard (Sinapis ssp., In particular Sinapis arvensis and Sinapis alba), Bertram root extracts (Anacyclus spp., In particular Anacyclus pyrethrum L. ), sun hatch extracts ( Echinaceae ssp .), Extracts of Szechuan pepper (Zanthoxylum ssp., Especially Zanthoxylum piperitum), Spilanthesextrakt ( Spilanthes ssp., Especially Spilanthes acmella), Chiliextrakt (Capsicum ssp., Capsicum frutescens particular ), grains of paradise extract ( Aframomum ssp ., Especially Aframomum melegueta [Rose] K. Schum.), ginger extract (Zingiber ssp ., especially Zingiber officinale ) and Galangaextrak t ( Kaempferia galanga or Alpinia galanga).
Eine besonders geeignete Substanz ist das aus dem Ingwerextrakt stammende Gingerol:
A particularly suitable substance is the gingerol derived from the ginger extract:
Einsetzbar ist auch N-Ethyl-p-menthan-3-carboxamid (N-Ethyl-5-Methyl-2-isopropylcyclohexancarboxamid):
It is also possible to use N-ethyl-p-menthane-3-carboxamide (N-ethyl-5-methyl-2-isopropylcyclohexanecarboxamide):
Andere scharf schmeckende oder ein Gefühl von Wärme erzeugende Substanzen können z.B. sein Capsaicin, Dihydrocapsaicin, Gingerol, Paradol, Shogaol, Piperin, Carbonsäure-N-vanillylamide, insbesondere Nonansäure-N- vanillylamid, 2-Alkensäureamide, insbesondere 2-Nonensäure-N-isobutylamid, 2- Nonensäure-N-4-hydroxy-3- methoxyphenylamid, Alkylether von 4-Hydroxy-3- methoxybenzylalkohol, insbesonders 4-Hydroxy-3-methoxybenzyl-n-butylether, Alkylether von 3- Hydroxy-4-methoxybenzylalkohol, Alkylether von 3,4- Dimethoxybenzylalkohol, Alkylether von 3-Ethoxy-4-hydroxybenzylalkohol, Alkylether von 3,4-Methylendioxybenzylalkohol, Nicotinaldehyd, Methylnicotinat, Propylnicotinat, 2-Butoxyethylnicotinat, Benzylnicotinat, 1-Acetoxychavicol, Polygodial oder Isodrimeninol.Other pungent or heat-producing substances may include, for example, capsaicin, dihydrocapsaicin, gingerol, paradol, shogaol, piperine, carboxylic acid N-vanillylamide, in particular nonanoic acid N-vanillylamide, 2-alkeneamic amides, in particular 2-nonenoic acid N-isobutylamide, 2-nonenoic acid N-4-hydroxy-3-methoxyphenylamide, alkyl ethers of 4-hydroxy-3-methoxybenzyl alcohol, in particular 4-hydroxy-3 methoxybenzyl n-butyl ether, alkyl ether of 3-hydroxy-4-methoxybenzyl alcohol, alkyl ether of 3,4-dimethoxybenzyl alcohol, alkyl ether of 3-ethoxy-4-hydroxybenzyl alcohol, alkyl ether of 3,4-methylenedioxybenzyl alcohol, nicotinaldehyde, methyl nicotinate, propyl nicotinate, 2 Butoxyethyl nicotinate, benzyl nicotinate, 1-acetoxychavicol, polygodial or isodrimeninol.
Besonders bevorzugte erfindungsgemäße Mund- und Zahnpflege- und -reinigungsmittel sind demnach dadurch gekennzeichnet, daß sie mindestens einen Scharfstoff aus der Gruppe der N-Alkyl-substituierte Amide von ungesättigten Carbonsäuren, vorzugsweise
- 2E,6Z,8E-Decatriensäure-N-isobutylamid (Spilanthol) und/oder
- 2E,4E,8Z-Decatriensäure-N-isobutylamid und/oder
- 2E,7Z,9E-Undecatriensäure-N-isobutylamid und/oder
- 2E,4Z-Decadiensäure-N-isobutylamid (cis-Pellitorin) und/oder
- 2E,4E-Decadiensäure-N-isobutylamid (trans-Pellitorin) und/oder
- Ferulasäure-N-Vanillylamid und/oder
- N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)- (2E)-propensäureamid (trans-Feruloylmethoxytyramin) und/oder
- N-[2- (4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2 Z)-propensäureamid (cis-Feruloylmethoxytyramin) und/oder
- N-[2-(4- Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-propansäureamid (Dihydroferuloylmethoxytyramin) und/oder
- N-[2-(3,4- Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloyldopamin) und/oder
- N-[2-(3,4-Dihydroxyphenyl) ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis- Feruloyldopamin) und/oder
- N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4- dihydroxyphenyl)-(2E)-propensäureamid (trans-Caffeoyltyramin) und/oder
- N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2Z)- propensäureamid (cis-Caffeoyltyramin) und/oder
- N-[2-(3,4-Dimethoxyphenyl) ethyl]-3-(3,4-dimethoxyphenyl)-(2E)-propensäureamid (trans- Rubenamin) und/oder
- N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(3,4- dimethoxy-phenyl)-(2Z)-propensäureamid (cis-Rubenamin)
enthalten
Particularly preferred oral and dental care and cleaning agents according to the invention are therefore characterized in that they contain at least one Scharfstoff from the group of N-alkyl-substituted amides of unsaturated carboxylic acids, preferably - 2E, 6Z, 8E-decatrienoic acid N-isobutylamide (Spilanthol) and / or
- 2E, 4E, 8Z-decatrienoic acid N-isobutylamide and / or
- 2E, 7Z, 9E-undecatrienoic acid N-isobutylamide and / or
- 2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin) and / or
- 2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin) and / or
- Ferulic acid N-vanillylamide and / or
- N - [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2 E ) -propenoic acid amide (trans -feruloylmethoxytyramine) and / or
- N - [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2 Z) -propenoic acid amide (cis-feruloylmethoxytyramine) and / or
- N - [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) -propanoic acid amide (dihydroferuloylmethoxytyramine) and / or
- N - [2- (3,4-dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2 E ) -propenoic acid amide (trans -feruloyldopamine) and / or
- N - [2- (3,4-dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxy-phenyl) - (2 Z) -propenoic acid amide (cis- Feruloyldopamin) and / or
- N - [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2 E) -propenoic acid amide (trans-caffeoyltyramine) and / or
- N - [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2Z) - propenoic acid amide (cis-caffeoyltyramine) and / or
- N - [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2 E ) -propenoic acid amide (trans-Rubenamine) and / or
- N - [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2 Z) -propenoic acid amide (cis-Ruben amine)
contain
Zusätzlich zu den genannten Scharfstoffen oder an ihrer Stelle können auch weitere scharf schmeckende und/oder ein Gefühl von Wärme erzeugende Substanzen in die erfindungsgemäßen Mund- und Zahnpflege- und -reinigungsmittel eingearbeitet werden.In addition to or in place of the above-mentioned acutance or other sharp-tasting and / or a feeling of heat-generating substances may be incorporated into the oral and dental care and cleaning compositions according to the invention.
Als besonders geeignet haben sich im Rahmen der vorliegenden Erfindung alkylsubstituierte Dioxane der Formel
Particularly suitable within the scope of the present invention are alkyl-substituted dioxanes of the formula
erwiesen, in der R1 und R2 unabhängig voneinander ausgewählt sind aus -H, -CH3, -CH2CH3 und R3 und R4 unabhängig voneinander ausgewählt sind aus -H, -CH3, -CH2CH3, -CH2CHZCH3, - CH(CH3)2. Einzelne Spezies, die der vorstehend genannten Formel genügen, sind hinsichtlich ihrer Reste R1, R2, R3 und R4 in der nachstehenden Tabelle 1 aufgeführt. Diese sind erfindungsgemäß besonders bevorzugt.
Tabelle 1: Bevorzugte alkylsubstituierte Dioxane: Nr. R1 R2 R3 R4
1 -H -CH3 -H -H
2 -H -CH2CH3 -H -H
3 -CH3 -CH3 -H -H
4 -CH3 -CH2CH3 -H -H
5 -CH2CH3 -CH2CH3 -H -H
6 -H -CH3 -H -CH3
7 -H -CH3 -H -CH2CH3
8 -H -CH3 -H -CH2CH2CH3
9 -H -CH3 -H -CH(CH3)2
10 -H -CH3 -CH3 -CH3
11 -H -CH3 -CH3 -CH2CH3
12 -H -CH3 -CH3 -CH2CH2CH3
13 -H -CH3 -CH3 -CH(CH3)2
14 -H -CH3 -CH2CH3 -CH2CH3
15 -H -CH3 -CH2CH3 -CH2CH2CH3
16 -H -CH3 -CH2CH3 -CH(CH3)2
17 -H -CH3 -CH2CH2CH3 -CH2CH2CH3
18 -H -CH3 -CH2CH2CH3 -CH(CH3)2
19 -H -CH3 -CH(CH3)2 -CH(CH3)2
20 -H -CH2CH3 -H -CH3
21 -H -CH2CH3 -H -CH2CH3
22 -H -CH2CH3 -H -CH2CH2CH3
23 -H -CH2CH3 -H -CH(CH3)2
24 -H -CH2CH3 -CH3 -CH3
25 -H -CH2CH3 -CH3 -CH2CH3
26 -H -CH2CH3 -CH3 -CH2CH2CH3
27 -H -CH2CH3 -CH3 -CH(CH3)2
28 -H -CH2CH3 -CH2CH3 -CH2CH3
29 -H -CH2CH3 -CH2CH3 -CH2CH2CH3
30 -H -CH2CH3 -CH2CH3 -CH(CH3)2
31 -H -CH2CH3 -CH2CH2CH3 -CH2CH2CH3
32 -H -CH2CH3 -CH2CH2CH3 -CH(CH3)2
33 -H -CH2CH3 -CH(CH3)2 -CH(CH3)2
34 -CH3 -CH3 -H -CH3
35 -CH3 -CH3 -H -CH2CH3
36 -CH3 -CH3 -H -CH2CH2CH3
37 -CH3 -CH3 -H -CH(CH3)2
38 -CH3 -CH3 -CH3 -CH3
39 -CH3 -CH3 -CH3 -CH2CH3
40 -CH3 -CH3 -CH3 -CH2CH2CH3
41 -CH3 -CH3 -CH3 -CH(CH3)2
42 -CH3 -CH3 -CH2CH3 -CH2CH3
43 -CH3 -CH3 -CH2CH3 -CH2CH2CH3
44 -CH3 -CH3 -CH2CH3 -CH(CH3)2
45 -CH3 -CH3 -CH2CH2CH3 -CH2CH2CH3
46 -CH3 -CH3 -CH2CH2CH3 -CH(CH3)2
47 -CH3 -CH3 -CH(CH3)2 -CH(CH3)2
48 -CH3 -CH2CH3 -H -CH3
49 -CH3 -CH2CH3 -H -CH2CH3
50 -CH3 -CH2CH3 -H -CH2CH2CH3
51 -CH3 -CH2CH3 -H -CH(CH3)2
52 -CH3 -CH2CH3 -CH3 -CH3
53 -CH3 -CH2CH3 -CH3 -CH2CH3
54 -CH3 -CH2CH3 -CH3 -CH2CH2CH3
55 -CH3 -CH2CH3 -CH3 -CH(CH3)2
56 -CH3 -CH2CH3 -CH2CH3 -CH2CH3
57 -CH3 -CH2CH3 -CH2CH3 -CH2CH2CH3
58 -CH3 -CH2CH3 -CH2CH3 -CH(CH3)2
59 -CH3 -CH2CH3 -CH2CH2CH3 -CH2CH2CH3
60 -CH3 -CH2CH3 -CH2CH2CH3 -CH(CH3)2
61 -CH3 -CH2CH3 -CH(CH3)2 -CH(CH3)2
62 -CH2CH3 -CH2CH3 -H -CH3
63 -CH2CH3 -CH2CH3 -H -CH2CH3
64 -CH2CH3 -CH2CH3 -H -CH2CH2CH3
65 -CH2CH3 -CH2CH3 -H -CH(CH3)2
66 -CH2CH3 -CH2CH3 -CH3 -CH3
67 -CH2CH3 -CH2CH3 -CH3 -CH2CH3
68 -CH2CH3 -CH2CH3 -CH3 -CH2CH2CH3
69 -CH2CH3 -CH2CH3 -CH3 -CH(CH3)2
70 -CH2CH3 -CH2CH3 -CH2CH3 -CH2CH3
71 -CH2CH3 -CH2CH3 -CH2CH3 -CH2CH2CH3
72 -CH2CH3 -CH2CH3 -CH2CH3 -CH(CH3)2
73 -CH2CH3 -CH2CH3 -CH2CH2CH3 -CH2CH2CH3
74 -CH2CH3 -CH2CH3 -CH2CH2CH3 -CH(CH3)2
75 -CH2CH3 -CH2CH3 -CH(CH3)2 -CH(CH3)2
proved, in which R1 and R2 are independently selected from -H, -CH 3, -CH 2 CH 3 and R3 and R4 are independently selected from -H, -CH 3, -CH 2 CH 3, -CH 2 CH Z is CH 3 , - CH (CH 3 ) 2 . Individual species satisfying the above formula are listed in Table 1 below for their R1, R2, R3 and R4 groups. These are particularly preferred according to the invention. Table 1: Preferred alkyl-substituted dioxanes: No. R1 R2 R3 R4
1 -H -CH 3 -H -H
2 -H -CH 2 CH 3 -H -H
3 -CH 3 -CH 3 -H -H
4 -CH 3 -CH 2 CH 3 -H -H
5 -CH 2 CH 3 -CH 2 CH 3 -H -H
6 -H -CH 3 -H -CH 3
7 -H -CH 3 -H -CH 2 CH 3
8th -H -CH 3 -H -CH 2 CH 2 CH 3
9 -H -CH 3 -H -CH (CH 3 ) 2
10 -H -CH 3 -CH 3 -CH 3
11 -H -CH 3 -CH 3 -CH 2 CH 3
12 -H -CH 3 -CH 3 -CH 2 CH 2 CH 3
13 -H -CH 3 -CH 3 -CH (CH 3 ) 2
14 -H -CH 3 -CH 2 CH 3 -CH 2 CH 3
15 -H -CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3
16 -H -CH 3 -CH 2 CH 3 -CH (CH 3 ) 2
17 -H -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
18 -H -CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2
19 -H -CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
20 -H -CH 2 CH 3 -H -CH 3
21 -H -CH 2 CH 3 -H -CH 2 CH 3
22 -H -CH 2 CH 3 -H -CH 2 CH 2 CH 3
23 -H -CH 2 CH 3 -H -CH (CH 3 ) 2
24 -H -CH 2 CH 3 -CH 3 -CH 3
25 -H -CH 2 CH 3 -CH 3 -CH 2 CH 3
26 -H -CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 3
27 -H -CH 2 CH 3 -CH 3 -CH (CH 3 ) 2
28 -H -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3
29 -H -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3
30 -H -CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2
31 -H -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
32 -H -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2
33 -H -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
34 -CH 3 -CH 3 -H -CH 3
35 -CH 3 -CH 3 -H -CH 2 CH 3
36 -CH 3 -CH 3 -H -CH 2 CH 2 CH 3
37 -CH 3 -CH 3 -H -CH (CH 3 ) 2
38 -CH 3 -CH 3 -CH 3 -CH 3
39 -CH 3 -CH 3 -CH 3 -CH 2 CH 3
40 -CH 3 -CH 3 -CH 3 -CH 2 CH 2 CH 3
41 -CH 3 -CH 3 -CH 3 -CH (CH 3 ) 2
42 -CH 3 -CH 3 -CH 2 CH 3 -CH 2 CH 3
43 -CH 3 -CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3
44 -CH 3 -CH 3 -CH 2 CH 3 -CH (CH 3 ) 2
45 -CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
46 -CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2
47 -CH 3 -CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
48 -CH 3 -CH 2 CH 3 -H -CH 3
49 -CH 3 -CH 2 CH 3 -H -CH 2 CH 3
50 -CH 3 -CH 2 CH 3 -H -CH 2 CH 2 CH 3
51 -CH 3 -CH 2 CH 3 -H -CH (CH 3 ) 2
52 -CH 3 -CH 2 CH 3 -CH 3 -CH 3
53 -CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 3
54 -CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 3
55 -CH 3 -CH 2 CH 3 -CH 3 -CH (CH 3 ) 2
56 -CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3
57 -CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3
58 -CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2
59 -CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
60 -CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2
61 -CH 3 -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
62 -CH 2 CH 3 -CH 2 CH 3 -H -CH 3
63 -CH 2 CH 3 -CH 2 CH 3 -H -CH 2 CH 3
64 -CH 2 CH 3 -CH 2 CH 3 -H -CH 2 CH 2 CH 3
65 -CH 2 CH 3 -CH 2 CH 3 -H -CH (CH 3 ) 2
66 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 3
67 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 3
68 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 3
69 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH (CH 3 ) 2
70 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3
71 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3
72 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2
73 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
74 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2
75 -CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
Als weiterhin besonders geeignet haben sich im Rahmen der vorliegenden Erfindung Phenylester der Formel
erwiesen, in der R5 für -CH3 oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen und R6 für -CH3 oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen oder eine Alkoxygruppe mit 1 bis 3 Kohlenstoffatomen stehtAs further particularly suitable in the context of the present invention phenyl esters of the formula proved, in which R 5 is -CH 3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms, and R6 is -CH3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms or an alkoxy group having 1 to 3 Carbon atoms
Einzelne Spezies, die der vorstehend genannten Formel genügen, sind hinsichtlich ihrer Reste R5 und R6 in der nachstehenden Tabelle 2 aufgeführt. Diese sind erfindungsgemäß besonders bevorzugt.
Tabelle 2: Bevorzugte Phenylester Nr. R5 R6
1 -CH3 -CH3
2 -CH2CH3 -CH3
3 -CH2CH2CH3 -CH3
4 -CH(CH3)2 -CH3
5 -CH2CH2CH2CH3 -CH3
6 -CH(CH3)CH2CH3 -CH3
7 -CH2CH(CH3)2 -CH3
8 -C(CH3)3 -CH3
9 -CH2(CH2)3CH3 -CH3
10 -CH(CH3)(CH2)2CH3 -CH3
11 -CH2CH(CH3)CH2CH3 -CH3
12 -(CH2)2CH(CH3)2 -CH3
13 -CH2(CH2)4CH3 -CH3
14 -CH2(CH2)5CH3 -CH3
15 -CH2(CH2)6CH3 -CH3
16 -CH=CH2 -CH3
17 -CH=CHCH3 -CH3
18 -CH=C(CH3)2 -CH3
19 -C(CH3)=CH2 -CH3
20 -C(CH3)=CHCH3 -CH3
21 -C(CH3)=C(CH3)2 -CH3
22 -CH=CH-CH2CH3 -CH3
23 -CH2CH=CH-CH3 -CH3
24 -(CH2)2CH=CH2 -CH3
25 -CH=CH-(CH2)2CH3 -CH3
26 -CH2CH=CH-CH2CH3 -CH3
27 -(CH2)2CH=CH-CH3 -CH3
28 -(CH2)3CH=CH2 -CH3
29 -CH=CH-(CH2)3CH3 -CH3
30 -CH2CH=CH-(CH2)2CH3 -CH3
31 -(CH2)2CH=CH-CH2CH3 -CH3
32 -(CH2)3CH=CH-CH3 -CH3
33 -(CH2)4CH=CH2 -CH3
34 -CH=CH-(CH2)3CH3 -CH3
35 -CH2CH=CH-(CH2)3CH3 -CH3
36 -(CH2)2CH=CH-(CH2)2CH3 -CH3
37 -(CH2)3CH=CH-CH2CH3 -CH3
38 -(CH2)4CH=CH-CH3 -CH3
39 -(CH2)5CH=CH2 -CH3
40 -CH=CH-(CH2)5CH3 -CH3
41 -CH2CH=CH-(CH2)4CH3 -CH3
42 -(CH2)2CH=CH-(CH2)3CH3 -CH3
43 -(CH2)3CH=CH-(CH2)2CH3 -CH3
44 -(CH2)4CH=CH-CH2CH3 -CH3
45 -(CH2)5CH=CH-CH3 -CH3
46 -(CH2)6CH=CH2 -CH3
47 -CH3 -CH2CH3
48 -CH2CH3 -CH2CH3
49 -CH2CH2CH3 -CH2CH3
50 -CH(CH3)2 -CH2CH3
51 -CH2CH2CH2CH3 -CH2CH3
52 -CH(CH3)CH2CH3 -CH2CH3
53 -CH2CH(CH3)2 -CH2CH3
54 -C(CH3)3 -CH2CH3
55 -CH2(CH2)3CH3 -CH2CH3
56 -CH(CH3)(CH2)2CH3 -CH2CH3
57 -CH2CH(CH3)CH2CH3 -CH2CH3
58 -(CH2)2CH(CH3)2 -CH2CH3
59 -CH2(CH2)4CH3 -CH2CH3
60 -CH2(CH2)sCH3 -CH2CH3
61 -CH2(CH2)6CH3 -CH2CH3
62 -CH=CH2 -CH2CH3
63 -CH=CHCH3 -CH2CH3
64 -CH=C(CH3)2 -CH2CH3
65 -C(CH3)=CH2 -CH2CH3
66 -C(CH3)=CHCH3 -CH2CH3
67 -C(CH3)=C(CH3)2 -CH2CH3
68 -CH=CH-CH2CH3 -CH2CH3
69 -CH2CH=CH-CH3 -CH2CH3
70 -(CH2)2CH=CH2 -CH2CH3
71 -CH=CH-(CH2)2CH3 -CH2CH3
72 -CH2CH=CH-CH2CH3 -CH2CH3
73 -(CH2)2CH=CH-CH3 -CH2CH3
74 -(CH2)3CH=CH2 -CH2CH3
75 -CH=CH-(CH2)3CH3 -CH2CH3
76 -CH2CH=CH-(CH2)2CH3 -CH2CH3
77 -(CH2)2CH=CH-CH2CH3 -CH2CH3
78 -(CH2)3CH=CH-CH3 -CH2CH3
79 -(CH2)4CH=CH2 -CH2CH3
80 -CH=CH-(CH2)3CH3 -CH2CH3
81 -CH2CH=CH-(CH2)3CH3 -CH2CH3
82 -(CH2)2CH=CH-(CH2)2CH3 -CH2CH3
83 -(CH2)3CH=CH-CH2CH3 -CH2CH3
84 -(CH2)4CH=CH-CH3 -CH2CH3
85 -(CH2)5CH=CH2 -CH2CH3
86 -CH=CH-(CH2)5CH3 -CH2CH3
87 -CH2CH=CH-(CH2)4CH3 -CH2CH3
88 -(CH2)2CH=CH-(CH2)3CH3 -CH2CH3
89 -(CH2)3CH=CH-(CH2)2CH3 -CH2CH3
90 -(CH2)4CH=CH-CH2CH3 -CH2CH3
91 -(CH2)5CH=CH-CH3 -CH2CH3
92 -(CH2)6CH=CH2 -CH2CH3
93 -CH3 -CH2CH2CH3
94 -CH2CH3 -CH2CH2CH3
95 -CH2CH2CH3 -CH2CH2CH3
96 -CH(CH3)2 -CH2CH2CH3
97 -CH2CH2CH2CH3 -CH2CH2CH3
98 -CH(CH3)CH2CH3 -CH2CH2CH3
99 -CH2CH(CH3)2 -CH2CH2CH3
100 -C(CH3)3 -CH2CH2CH3
101 -CH2(CH2)3CH3 -CH2CH2CH3
102 -CH(CH3)(CH2)2CH3 -CH2CH2CH3
103 -CH2CH(CH3)CH2CH3 -CH2CH2CH3
104 -(CH2)2CH(CH3)2 -CH2CH2CH3
105 -CH2(CH2)4CH3 -CH2CH2CH3
106 -CH2(CH2)5CH3 -CH2CH2CH3
107 -CH2(CH2)6CH3 -CH2CH2CH3
108 -CH=CH2 -CH2CH2CH3
109 -CH=CHCH3 -CH2CH2CH3
110 -CH=C(CH3)2 -CH2CH2CH3
111 -C(CH3)=CH2 -CH2CH2CH3
112 -C(CH3)=CHCH3 -CH2CH2CH3
113 -C(CH3)=C(CH3)2 -CH2CH2CH3
114 -CH=CH-CH2CH3 -CH2CH2CH3
115 -CH2CH=CH-CH3 -CH2CH2CH3
116 -(CH2)2CH=CH2 -CH2CH2CH3
117 -CH=CH-(CH2)2CH3 -CH2CH2CH3
118 -CH2CH=CH-CH2CH3 -CH2CH2CH3
119 -(CH2)2CH=CH-CH3 -CH2CH2CH3
120 -(CH2)3CH=CH2 -CH2CH2CH3
121 -CH=CH-(CH2)3CH3 -CH2CH2CH3
122 -CH2CH=CH-(CH2)2CH3 -CH2CH2CH3
123 -(CH2)2CH=CH-CH2CH3 -CH2CH2CH3
124 -(CH2)3CH=CH-CH3 -CH2CH2CH3
125 -(CH2)4CH=CH2 -CH2CH2CH3
126 -CH=CH-(CH2)3CH3 -CH2CH2CH3
127 -CH2CH=CH-(CH2)3CH3 -CH2CH2CH3
128 -(CH2)2CH=CH-(CH2)2CH3 -CH2CH2CH3
129 -(CH2)3CH=CH-CH2CH3 -CH2CH2CH3
130 -(CH2)4CH=CH-CH3 -CH2CH2CH3
131 -(CH2)5CH=CH2 -CH2CH2CH3
132 -CH=CH-(CH2)5CH3 -CH2CH2CH3
133 -CH2CH=CH-(CH2)4CH3 -CH2CH2CH3
134 -(CH2)2CH=CH-(CH2)3CH3 -CH2CH2CH3
135 -(CH2)3CH=CH-(CH2)2CH3 -CH2CH2CH3
136 -(CH2)4CH=CH-CH2CH3 -CH2CH2CH3
137 -(CH2)5CH=CH-CH3 -CH2CH2CH3
138 -(CH2)6CH=CH2 -CH2CH2CH3
139 -CH3 -CH(CH3)2
140 -CH2CH3 -CH(CH3)2
141 -CH2CH2CH3 -CH(CH3)2
142 -CH(CH3)2 -CH(CH3)2
143 -CH2CH2CH2CH3 -CH(CH3)2
144 -CH(CH3)CH2CH3 -CH(CH3)2
145 -CH2CH(CH3)2 -CH(CH3)2
146 -C(CH3)3 -CH(CH3)2
147 -CH2(CH2)3CH3 -CH(CH3)2
148 -CH(CH3)(CH2)2CH3 -CH(CH3)2
149 -CH2CH(CH3)CH2CH3 -CH(CH3)2
150 -(CH2)2CH(CH3)2 -CH(CH3)2
151 -CH2(CH2)4CH3 -CH(CH3)2
152 -CH2(CH2)5CH3 -CH(CH3)2
153 -CH2(CH2)6CH3 -CH(CH3)2
154 -CH=CH2 -CH(CH3)2
155 -CH=CHCH3 -CH(CH3)2
156 -CH=C(CH3)2 -CH(CH3)2
157 -C(CH3)=CH2 -CH(CH3)2
158 -C(CH3)=CHCH3 -CH(CH3)2
159 -C(CH3)=C(CH3)2 -CH(CH3)2
160 -CH=CH-CH2CH3 -CH(CH3)2
161 -CH2CH=CH-CH3 -CH(CH3)2
162 -(CH2)2CH=CH2 -CH(CH3)2
163 -CH=CH-(CH2)2CH3 -CH(CH3)2
164 -CH2CH=CH-CH2CH3 -CH(CH3)2
165 -(CH2)2CH=CH-CH3 -CH(CH3)2
166 -(CH2)3CH=CH2 -CH(CH3)2
167 -CH=CH-(CH2)3CH3 -CH(CH3)2
168 -CH2CH=CH-(CH2)2CH3 -CH(CH3)2
169 -(CH2)2CH=CH-CH2CH3 -CH(CH3)2
170 -(CH2)3CH=CH-CH3 -CH(CH3)2
171 -(CH2)4CH=CH2 -CH(CH3)2
172 -CH=CH-(CH2)3CH3 -CH(CH3)2
173 -CH2CH=CH-(CH2)3CH3 -CH(CH3)2
174 -(CH2)2CH=CH-(CH2)2CH3 -CH(CH3)2
175 -(CH2)3CH=CH-CH2CH3 -CH(CH3)2
176 -(CH2)4CH=CH-CH3 -CH(CH3)2
177 -(CH2)5CH=CH2 -CH(CH3)2
178 -CH=CH-(CH2)5CH3 -CH(CH3)2
179 -CH2CH=CH-(CH2)4CH3 -CH(CH3)2
180 -(CH2)2CH=CH-(CH2)3CH3 -CH(CH3)2
181 -(CH2)3CH=CH-(CH2)2CH3 -CH(CH3)2
182 -(CH2)4CH=CH-CH2CH3 -CH(CH3)2
183 -(CH2)5CH=CH-CH3 -CH(CH3)2
184 -(CH2)6CH=CH2 -CH(CH3)2
185 -CH3 -CH2CH2CH2CH3
186 -CH2CH3 -CH2CH2CH2CH3
187 -CH2CH2CH3 -CH2CH2CH2CH3
188 -CH(CH3)2 -CH2CH2CH2CH3
189 -CH2CH2CH2CH3 -CH2CH2CH2CH3
190 -CH(CH3)CH2CH3 -CH2CH2CH2CH3
191 -CH2CH(CH3)2 -CH2CH2CH2CH3
192 -C(CH3)3 -CH2CH2CH2CH3
193 -CH2(CH2)3CH3 -CH2CH2CH2CH3
194 -CH(CH3)(CH2)2CH3 -CH2CH2CH2CH3
195 -CH2CH(CH3)CH2CH3 -CH2CH2CH2CH3
196 -(CH2)2CH(CH3)2 -CH2CH2CH2CH3
197 -CH2(CH2)4CH3 -CH2CH2CH2CH3
198 -CH2(CH2)5CH3 -CH2CH2CH2CH3
199 -CH2(CH2)6CH3 -CH2CH2CH2CH3
200 -CH=CH2 -CH2CH2CH2CH3
201 -CH=CHCH3 -CH2CH2CH2CH3
202 -CH=C(CH3)2 -CH2CH2CH2CH3
203 -C(CH3)=CH2 -CH2CH2CH2CH3
204 -C(CH3)=CHCH3 -CH2CH2CH2CH3
205 -C(CH3)=C(CH3)2 -CH2CH2CH2CH3
206 -CH=CH-CH2CH3 -CH2CH2CH2CH3
207 -CH2CH=CH-CH3 -CH2CH2CH2CH3
208 -(CH2)2CH=CH2 -CH2CH2CH2CH3
209 -CH=CH-(CH2)2CH3 -CH2CH2CH2CH3
210 -CH2CH=CH-CH2CH3 -CH2CH2CH2CH3
211 -(CH2)2CH=CH-CH3 -CH2CH2CH2CH3
212 -(CH2)3CH=CH2 -CH2CH2CH2CH3
213 -CH=CH-(CH2)3CH3 -CH2CH2CH2CH3
214 -CH2CH=CH-(CH2)2CH3 -CH2CH2CH2CH3
215 -(CH2)2CH=CH-CH2CH3 -CH2CH2CH2CH3
216 -(CH2)3CH=CH-CH3 -CH2CH2CH2CH3
217 -(CH2)4CH=CH2 -CH2CH2CH2CH3
218 -CH=CH-(CH2)3CH3 -CH2CH2CH2CH3
219 -CH2CH=CH-(CH2)3CH3 -CH2CH2CH2CH3
220 -(CH2)2CH=CH-(CH2)2CH3 -CH2CH2CH2CH3
221 -(CH2)3CH=CH-CH2CH3 -CH2CH2CH2CH3
222 -(CH2)4CH=CH-CH3 -CH2CH2CH2CH3
223 -(CH2)5CH=CH2 -CH2CH2CH2CH3
224 -CH=CH-(CH2)5CH3 -CH2CH2CH2CH3
225 -CH2CH=CH-(CH2)4CH3 -CH2CH2CH2CH3
226 -(CH2)2CH=CH-(CH2)3CH3 -CH2CH2CH2CH3
227 -(CH2)3CH=CH-(CH2)2CH3 -CH2CH2CH2CH3
228 -(CH2)4CH=CH-CH2CH3 -CH2CH2CH2CH3
229 -(CH2)5CH=CH-CH3 -CH2CH2CH2CH3
230 -(CH2)6CH=CH2 -CH2CH2CH2CH3
231 -CH3 -CH(CH3)CH2CH3
232 -CH2CH3 -CH(CH3)CH2CH3
233 -CH2CH2CH3 -CH(CH3)CH2CH3
234 -CH(CH3)2 -CH(CH3)CH2CH3
235 -CH2CH2CH2CH3 -CH(CH3)CH2CH3
236 -CH(CH3)CH2CH3 -CH(CH3)CH2CH3
237 -CH2CH(CH3)2 -CH(CH3)CH2CH3
238 -C(CH3)3 -CH(CH3)CH2CH3
239 -CH2(CH2)3CH3 -CH(CH3)CH2CH3
240 -CH(CH3)(CH2)2CH3 -CH(CH3)CH2CH3
241 -CH2CH(CH3)CH2CH3 -CH(CH3)CH2CH3
242 -(CH2)2CH(CH3)2 -CH(CH3)CH2CH3
243 -CH2(CH2)4CH3 -CH(CH3)CH2CH3
244 -CH2(CH2)5CH3 -CH(CH3)CH2CH3
245 -CH2(CH2)6CH3 -CH(CH3)CH2CH3
246 -CH=CH2 -CH(CH3)CH2CH3
247 -CH=CHCH3 -CH(CH3)CH2CH3
248 -CH=C(CH3)2 -CH(CH3)CH2CH3
249 -C(CH3)=CH2 -CH(CH3)CH2CH3
250 -C(CH3)=CHCH3 -CH(CH3)CH2CH3
251 -C(CH3)=C(CH3)2 -CH(CH3)CH2CH3
252 -CH=CH-CH2CH3 -CH(CH3)CH2CH3
253 -CH2CH=CH-CH3 -CH(CH3)CH2CH3
254 -(CH2)2CH=CH2 -CH(CH3)CH2CH3
255 -CH=CH-(CH2)2CH3 -CH(CH3)CH2CH3
256 -CH2CH=CH-CH2CH3 -CH(CH3)CH2CH3
257 -(CH2)2CH=CH-CH3 -CH(CH3)CH2CH3
258 -(CH2)3CH=CH2 -CH(CH3)CH2CH3
259 -CH=CH-(CH2)3CH3 -CH(CH3)CH2CH3
260 -CH2CH=CH-(CH2)2CH3 -CH(CH3)CH2CH3
261 -(CH2)2CH=CH-CH2CH3 -CH(CH3)CH2CH3
262 -(CH2)3CH=CH-CH3 -CH(CH3)CH2CH3
263 -(CH2)4CH=CH2 -CH(CH3)CH2CH3
264 -CH=CH-(CH2)3CH3 -CH(CH3)CH2CH3
265 -CH2CH=CH-(CH2)3CH3 -CH(CH3)CH2CH3
266 -(CH2)2CH=CH-(CH2)2CH3 -CH(CH3)CH2CH3
267 -(CH2)3CH=CH-CH2CH3 -CH(CH3)CH2CH3
268 -(CH2)4CH=CH-CH3 -CH(CH3)CH2CH3
269 -(CH2)5CH=CH2 -CH(CH3)CH2CH3
270 -CH=CH-(CH2)5CH3 -CH(CH3)CH2CH3
271 -CH2CH=CH-(CH2)4CH3 -CH(CH3)CH2CH3
272 -(CH2)2CH=CH-(CH2)3CH3 -CH(CH3)CH2CH3
273 -(CH2)3CH=CH-(CH2)2CH3 -CH(CH3)CH2CH3
274 -(CH2)4CH=CH-CH2CH3 -CH(CH3)CH2CH3
275 -(CH2)5CH=CH-CH3 -CH(CH3)CH2CH3
276 -(CH2)6CH=CH2 -CH(CH3)CH2CH3
277 -CH3 -CH2CH(CH3)2
278 -CH2CH3 -CH2CH(CH3)2
279 -CH2CH2CH3 -CH2CH(CH3)2
280 -CH(CH3)2 -CH2CH(CH3)2
281 -CH2CH2CH2CH3 -CH2CH(CH3)2
282 -CH(CH3)CH2CH3 -CH2CH(CH3)2
283 -CH2CH(CH3)2 -CH2CH(CH3)2
284 -C(CH3)3 -CH2CH(CH3)2
285 -CH2(CH2)3CH3 -CH2CH(CH3)2
286 -CH(CH3)(CH2)2CH3 -CH2CH(CH3)2
287 -CH2CH(CH3)CH2CH3 -CH2CH(CH3)2
288 -(CH2)2CH(CH3)2 -CH2CH(CH3)2
289 -CH2(CH2)4CH3 -CH2CH(CH3)2
290 -CH2(CH2)5CH3 -CH2CH(CH3)2
291 -CH2(CH2)6CH3 -CH2CH(CH3)2
292 -CH=CH2 -CH2CH(CH3)2
293 -CH=CHCH3 -CH2CH(CH3)2
294 -CH=C(CH3)2 -CH2CH(CH3)2
295 -C(CH3)=CH2 -CH2CH(CH3)2
296 -C(CH3)=CHCH3 -CH2CH(CH3)2
297 -C(CH3)=C(CH3)2 -CH2CH(CH3)2
298 -CH=CH-CH2CH3 -CH2CH(CH3)2
299 -CH2CH=CH-CH3 -CH2CH(CH3)2
300 -(CH2)2CH=CH2 -CH2CH(CH3)2
301 -CH=CH-(CH2)2CH3 -CH2CH(CH3)2
302 -CH2CH=CH-CH2CH3 -CH2CH(CH3)2
303 -(CH2)2CH=CH-CH3 -CH2CH(CH3)2
304 -(CH2)3CH=CH2 -CH2CH(CH3)2
305 -CH=CH-(CH2)3CH3 -CH2CH(CH3)2
306 -CH2CH=CH-(CH2)2CH3 -CH2CH(CH3)2
307 -(CH2)2CH=CH-CH2CH3 -CH2CH(CH3)2
308 -(CH2)3CH=CH-CH3 -CH2CH(CH3)2
309 -(CH2)4CH=CH2 -CH2CH(CH3)2
310 -CH=CH-(CH2)3CH3 -CH2CH(CH3)2
311 -CH2CH=CH-(CH2)3CH3 -CH2CH(CH3)2
312 -(CH2)2CH=CH-(CH2)2CH3 -CH2CH(CH3)2
313 -(CH2)3CH=CH-CH2CH3 -CH2CH(CH3)2
314 -(CH2)4CH=CH-CH3 -CH2CH(CH3)2
315 -(CH2)5CH=CH2 -CH2CH(CH3)2
316 -CH=CH-(CH2)5CH3 -CH2CH(CH3)2
317 -CH2CH=CH-(CH2)4CH3 -CH2CH(CH3)2
318 -(CH2)2CH=CH-(CH2)3CH3 -CH2CH(CH3)2
319 -(CH2)3CH=CH-(CH2)2CH3 -CH2CH(CH3)2
320 -(CH2)4CH=CH-CH2CH3 -CH2CH(CH3)2
321 -(CH2)5CH=CH-CH3 -CH2CH(CH3)2
322 -(CH2)6CH=CH2 -CH2CH(CH3)2
323 -CH3 -C(CH3)3
324 -CH2CH3 -C(CH3)3
325 -CH2CH2CH3 -C(CH3)3
326 -CH(CH3)2 -C(CH3)3
327 -CH2CH2CH2CH3 -C(CH3)3
328 -CH(CH3)CH2CH3 -C(CH3)3
329 -CH2CH(CH3)2 -C(CH3)3
330 -C(CH3)3 -C(CH3)3
331 -CH2(CH2)3CH3 -C(CH3)3
332 -CH(CH3)(CH2)2CH3 -C(CH3)3
333 -CH2CH(CH3)CH2CH3 -C(CH3)3
334 -(CH2)2CH(CH3)2 -C(CH3)3
335 -CH2(CH2)4CH3 -C(CH3)3
336 -CH2(CH2)sCH3 -C(CH3)3
337 -CH2(CH2)6CH3 -C(CH3)3
338 -CH=CH2 -C(CH3)3
339 -CH=CHCH3 -C(CH3)3
340 -CH=C(CH3)2 -C(CH3)3
341 -C(CH3)=CH2 -C(CH3)3
342 -C(CH3)=CHCH3 -C(CH3)3
343 -C(CH3)=C(CH3)2 -C(CH3)3
344 -CH=CH-CH2CH3 -C(CH3)3
345 -CH2CH=CH-CH3 -C(CH3)3
346 -(CH2)2CH=CH2 -C(CH3)3
347 -CH=CH-(CH2)2CH3 -C(CH3)3
348 -CH2CH=CH-CH2CH3 -C(CH3)3
349 -(CH2)2CH=CH-CH3 -C(CH3)3
350 -(CH2)3CH=CH2 -C(CH3)3
351 -CH=CH-(CH2)3CH3 -C(CH3)3
352 -CH2CH=CH-(CH2)2CH3 -C(CH3)3
353 -(CH2)2CH=CH-CH2CH3 -C(CH3)3
354 -(CH2)3CH=CH-CH3 -C(CH3)3
355 -(CH2)4CH=CH2 -C(CH3)3
356 -CH=CH-(CH2)3CH3 -C(CH3)3
357 -CH2CH=CH-(CH2)3CH3 -C(CH3)3
358 -(CH2)2CH=CH-(CH2)2CH3 -C(CH3)3
359 -(CH2)3CH=CH-CH2CH3 -C(CH3)3
360 -(CH2)4CH=CH-CH3 -C(CH3)3
361 -(CH2)5CH=CH2 -C(CH3)3
362 -CH=CH-(CH2)5CH3 -C(CH3)3
363 -CH2CH=CH-(CH2)4CH3 -C(CH3)3
364 -(CH2)2CH=CH-(CH2)3CH3 -C(CH3)3
365 -(CH2)3CH=CH-(CH2)2CH3 -C(CH3)3
366 -(CH2)4CH=CH-CH2CH3 -C(CH3)3
367 -(CH2)5CH=CH-CH3 -C(CH3)3
368 -(CH2)6CH=CH2 -C(CH3)3
369 -CH3 -CH2(CH2)3CH3
370 -CH2CH3 -CH2(CH2)3CH3
371 -CH2CH2CH3 -CH2(CH2)3CH3
372 -CH(CH3)2 -CH2(CH2)3CH3
373 -CH2CH2CH2CH3 -CH2(CH2)3CH3
374 -CH(CH3)CH2CH3 -CH2(CH2)3CH3
375 -CH2CH(CH3)2 -CH2(CH2)3CH3
376 -C(CH3)3 -CH2(CH2)3CH3
377 -CH2(CH2)3CH3 -CH2(CH2)3CH3
378 -CH(CH3)(CH2)2CH3 -CH2(CH2)3CH3
379 -CH2CH(CH3)CH2CH3 -CH2(CH2)3CH3
380 -(CH2)2CH(CH3)2 -CH2(CH2)3CH3
381 -CH2(CH2)4CH3 -CH2(CH2)3CH3
382 -CH2(CH2)5CH3 -CH2(CH2)3CH3
383 -CH2(CH2)6CH3 -CH2(CH2)3CH3
384 -CH=CH2 -CH2(CH2)3CH3
385 -CH=CHCH3 -CH2(CH2)3CH3
386 -CH=C(CH3)2 -CH2(CH2)3CH3
387 -C(CH3)=CH2 -CH2(CH2)3CH3
388 -C(CH3)=CHCH3 -CH2(CH2)3CH3
389 -C(CH3)=C(CH3)2 -CH2(CH2)3CH3
390 -CH=CH-CH2CH3 -CH2(CH2)3CH3
391 -CH2CH=CH-CH3 -CH2(CH2)3CH3
392 -(CH2)2CH=CH2 -CH2(CH2)3CH3
393 -CH=CH-(CH2)2CH3 -CH2(CH2)3CH3
394 -CH2CH=CH-CH2CH3 -CH2(CH2)3CH3
395 -(CH2)2CH=CH-CH3 -CH2(CH2)3CH3
396 -(CH2)3CH=CH2 -CH2(CH2)3CH3
397 -CH=CH-(CH2)3CH3 -CH2(CH2)3CH3
398 -CH2CH=CH-(CH2)2CH3 -CH2(CH2)3CH3
399 -(CH2)2CH=CH-CH2CH3 -CH2(CH2)3CH3
400 -(CH2)3CH=CH-CH3 -CH2(CH2)3CH3
401 -(CH2)4CH=CH2 -CH2(CH2)3CH3
402 -CH=CH-(CH2)3CH3 -CH2(CH2)3CH3
403 -CH2CH=CH-(CH2)3CH3 -CH2(CH2)3CH3
404 -(CH2)2CH=CH-(CH2)2CH3 -CH2(CH2)3CH3
405 -(CH2)3CH=CH-CH2CH3 -CH2(CH2)3CH3
406 -(CH2)4CH=CH-CH3 -CH2(CH2)3CH3
407 -(CH2)5CH=CH2 -CH2(CH2)3CH3
408 -CH=CH-(CH2)5CH3 -CH2(CH2)3CH3
409 -CH2CH=CH-(CH2)4CH3 -CH2(CH2)3CH3
410 -(CH2)2CH=CH-(CH2)3CH3 -CH2(CH2)3CH3
411 -(CH2)3CH=CH-(CH2)2CH3 -CH2(CH2)3CH3
412 -(CH2)4CH=CH-CH2CH3 -CH2(CH2)3CH3
413 -(CH2)5CH=CH-CH3 -CH2(CH2)3CH3
414 -(CH2)6CH=CH2 -CH2(CH2)3CH3
415 -CH3 -CH(CH3)(CH2)2CH3
416 -CH2CH3 -CH(CH3)(CH2)2CH3
417 -CH2CH2CH3 -CH(CH3)(CH2)2CH3
418 -CH(CH3)2 -CH(CH3)(CH2)2CH3
419 -CH2CH2CH2CH3 -CH(CH3)(CH2)2CH3
420 -CH(CH3)CH2CH3 -CH(CH3)(CH2)2CH3
421 -CH2CH(CH3)2 -CH(CH3)(CH2)2CH3
422 -C(CH3)3 -CH(CH3)(CH2)2CH3
423 -CH2(CH2)3CH3 -CH(CH3)(CH2)2CH3
424 -CH(CH3)(CH2)2CH3 -CH(CH3)(CH2)2CH3
425 -CH2CH(CH3)CH2CH3 -CH(CH3)(CH2)2CH3
426 -(CH2)2CH(CH3)2 -CH(CH3)(CH2)2CH3
427 -CH2(CH2)4CH3 -CH(CH3)(CH2)2CH3
428 -CH2(CH2)5CH3 -CH(CH3)(CH2)2CH3
429 -CH2(CH2)6CH3 -CH(CH3)(CH2)2CH3
430 -CH=CH2 -CH(CH3)(CH2)2CH3
431 -CH=CHCH3 -CH(CH3)(CH2)2CH3
432 -CH=C(CH3)2 -CH(CH3)(CH2)2CH3
433 -C(CH3)=CH2 -CH(CH3)(CH2)2CH3
434 -C(CH3)=CHCH3 -CH(CH3)(CH2)2CH3
435 -C(CH3)=C(CH3)2 -CH(CH3)(CH2)2CH3
436 -CH=CH-CH2CH3 -CH(CH3)(CH2)2CH3
437 -CH2CH=CH-CH3 -CH(CH3)(CH2)2CH3
438 -(CH2)2CH=CH2 -CH(CH3)(CH2)2CH3
439 -CH=CH-(CH2)2CH3 -CH(CH3)(CH2)2CH3
440 -CH2CH=CH-CH2CH3 -CH(CH3)(CH2)2CH3
441 -(CH2)2CH=CH-CH3 -CH(CH3)(CH2)2CH3
442 -(CH2)3CH=CH2 -CH(CH3)(CH2)2CH3
443 -CH=CH-(CH2)3CH3 -CH(CH3)(CH2)2CH3
444 -CH2CH=CH-(CH2)2CH3 -CH(CH3)(CH2)2CH3
445 -(CH2)2CH=CH-CH2CH3 -CH(CH3)(CH2)2CH3
446 -(CH2)3CH=CH-CH3 -CH(CH3)(CH2)2CH3
447 -(CH2)4CH=CH2 -CH(CH3)(CH2)2CH3
448 -CH=CH-(CH2)3CH3 -CH(CH3)(CH2)2CH3
449 -CH2CH=CH-(CH2)3CH3 -CH(CH3)(CH2)2CH3
450 -(CH2)2CH=CH-(CH2)2CH3 -CH(CH3)(CH2)2CH3
451 -(CH2)3CH=CH-CH2CH3 -CH(CH3)(CH2)2CH3
452 -(CH2)4CH=CH-CH3 -CH(CH3)(CH2)2CH3
453 -(CH2)5CH=CH2 -CH(CH3)(CH2)2CH3
454 -CH=CH-(CH2)5CH3 -CH(CH3)(CH2)2CH3
455 -CH2CH=CH-(CH2)4CH3 -CH(CH3)(CH2)2CH3
456 -(CH2)2CH=CH-(CH2)3CH3 -CH(CH3)(CH2)2CH3
457 -(CH2)3CH=CH-(CH2)2CH3 -CH(CH3)(CH2)2CH3
458 -(CH2)4CH=CH-CH2CH3 -CH(CH3)(CH2)2CH3
459 -(CH2)5CH=CH-CH3 -CH(CH3)(CH2)2CH3
460 -(CH2)6CH=CH2 -CH(CH3)(CH2)2CH3
461 -CH3 -CH2CH(CH3)CH2CH3
462 -CH2CH3 -CH2CH(CH3)CH2CH3
463 -CH2CH2CH3 -CH2CH(CH3)CH2CH3
464 -CH(CH3)2 -CH2CH(CH3)CH2CH3
465 -CH2CH2CH2CH3 -CH2CH(CH3)CH2CH3
466 -CH(CH3)CH2CH3 -CH2CH(CH3)CH2CH3
467 -CH2CH(CH3)2 -CH2CH(CH3)CH2CH3
468 -C(CH3)3 -CH2CH(CH3)CH2CH3
469 -CH2(CH2)3CH3 -CH2CH(CH3)CH2CH3
470 -CH(CH3)(CH2)2CH3 -CH2CH(CH3)CH2CH3
471 -CH2CH(CH3)CH2CH3 -CH2CH(CH3)CH2CH3
472 -(CH2)2CH(CH3)2 -CH2CH(CH3)CH2CH3
473 -CH2(CH2)4CH3 -CH2CH(CH3)CH2CH3
474 -CH2(CH2)5CH3 -CH2CH(CH3)CH2CH3
475 -CH2(CH2)6CH3 -CH2CH(CH3)CH2CH3
476 -CH=CH2 -CH2CH(CH3)CH2CH3
477 -CH=CHCH3 -CH2CH(CH3)CH2CH3
478 -CH=C(CH3)2 -CH2CH(CH3)CH2CH3
479 -C(CH3)=CH2 -CH2CH(CH3)CH2CH3
480 -C(CH3)=CHCH3 -CH2CH(CH3)CH2CH3
481 -C(CH3)=C(CH3)2 -CH2CH(CH3)CH2CH3
482 -CH=CH-CH2CH3 -CH2CH(CH3)CH2CH3
483 -CH2CH=CH-CH3 -CH2CH(CH3)CH2CH3
484 -(CH2)2CH=CH2 -CH2CH(CH3)CH2CH3
485 -CH=CH-(CH2)2CH3 -CH2CH(CH3)CH2CH3
486 -CH2CH=CH-CH2CH3 -CH2CH(CH3)CH2CH3
487 -(CH2)2CH=CH-CH3 -CH2CH(CH3)CH2CH3
488 -(CH2)3CH=CH2 -CH2CH(CH3)CH2CH3
489 -CH=CH-(CH2)3CH3 -CH2CH(CH3)CH2CH3
490 -CH2CH=CH-(CH2)2CH3 -CH2CH(CH3)CH2CH3
491 -(CH2)2CH=CH-CH2CH3 -CH2CH(CH3)CH2CH3
492 -(CH2)3CH=CH-CH3 -CH2CH(CH3)CH2CH3
493 -(CH2)4CH=CH2 -CH2CH(CH3)CH2CH3
494 -CH=CH-(CH2)3CH3 -CH2CH(CH3)CH2CH3
495 -CH2CH=CH-(CH2)3CH3 -CH2CH(CH3)CH2CH3
496 -(CH2)2CH=CH-(CH2)2CH3 -CH2CH(CH3)CH2CH3
497 -(CH2)3CH=CH-CH2CH3 -CH2CH(CH3)CH2CH3
498 -(CH2)4CH=CH-CH3 -CH2CH(CH3)CH2CH3
499 -(CH2)5CH=CH2 -CH2CH(CH3)CH2CH3
500 -CH=CH-(CH2)5CH3 -CH2CH(CH3)CH2CH3
501 -CH2CH=CH-(CH2)4CH3 -CH2CH(CH3)CH2CH3
502 -(CH2)2CH=CH-(CH2)3CH3 -CH2CH(CH3)CH2CH3
503 -(CH2)3CH=CH-(CH2)2CH3 -CH2CH(CH3)CH2CH3
504 -(CH2)4CH=CH-CH2CH3 -CH2CH(CH3)CH2CH3
505 -(CH2)5CH=CH-CH3 -CH2CH(CH3)CH2CH3
506 -(CH2)6CH=CH2 -CH2CH(CH3)CH2CH3
507 -CH3 -(CH2)2CH(CH3)2
508 -CH2CH3 -(CH2)2CH(CH3)2
509 -CH2CH2CH3 -(CH2)2CH(CH3)2
510 -CH(CH3)2 -(CH2)2CH(CH3)2
511 -CH2CH2CH2CH3 -(CH2)2CH(CH3)2
512 -CH(CH3)CH2CH3 -(CH2)2CH(CH3)2
513 -CH2CH(CH3)2 -(CH2)2CH(CH3)2
514 -C(CH3)3 -(CH2)2CH(CH3)2
515 -CH2(CH2)3CH3 -(CH2)2CH(CH3)2
516 -CH(CH3)(CH2)2CH3 -(CH2)2CH(CH3)2
517 -CH2CH(CH3)CH2CH3 -(CH2)2CH(CH3)2
518 -(CH2)2CH(CH3)2 -(CH2)2CH(CH3)2
519 -CH2(CH2)4CH3 -(CH2)2CH(CH3)2
520 -CH2(CH2)5CH3 -(CH2)2CH(CH3)2
521 -CH2(CH2)6CH3 -(CH2)2CH(CH3)2
522 -CH=CH2 -(CH2)2CH(CH3)2
523 -CH=CHCH3 -(CH2)2CH(CH3)2
524 -CH=C(CH3)2 -(CH2)2CH(CH3)2
525 -C(CH3)=CH2 -(CH2)2CH(CH3)2
526 -C(CH3)=CHCH3 -(CH2)2CH(CH3)2
527 -C(CH3)=C(CH3)2 -(CH2)2CH(CH3)2
528 -CH=CH-CH2CH3 -(CH2)2CH(CH3)2
529 -CH2CH=CH-CH3 -(CH2)2CH(CH3)2
530 -(CH2)2CH=CH2 -(CH2)2CH(CH3)2
531 -CH=CH-(CH2)2CH3 -(CH2)2CH(CH3)2
532 -CH2CH=CH-CH2CH3 -(CH2)2CH(CH3)2
533 -(CH2)2CH=CH-CH3 -(CH2)2CH(CH3)2
534 -(CH2)3CH=CH2 -(CH2)2CH(CH3)2
535 -CH=CH-(CH2)3CH3 -(CH2)2CH(CH3)2
536 -CH2CH=CH-(CH2)2CH3 -(CH2)2CH(CH3)2
537 -(CH2)2CH=CH-CH2CH3 -(CH2)2CH(CH3)2
538 -(CH2)3CH=CH-CH3 -(CH2)2CH(CH3)2
539 -(CH2)4CH=CH2 -(CH2)2CH(CH3)2
540 -CH=CH-(CH2)3CH3 -(CH2)2CH(CH3)2
541 -CH2CH=CH-(CH2)3CH3 -(CH2)2CH(CH3)2
542 -(CH2)2CH=CH-(CH2)2CH3 -(CH2)2CH(CH3)2
543 -(CH2)3CH=CH-CH2CH3 -(CH2)2CH(CH3)2
544 -(CH2)4CH=CH-CH3 -(CH2)2CH(CH3)2
545 -(CH2)5CH=CH2 -(CH2)2CH(CH3)2
546 -CH=CH-(CH2)5CH3 -(CH2)2CH(CH3)2
547 -CH2CH=CH-(CH2)4CH3 -(CH2)2CH(CH3)2
548 -(CH2)2CH=CH-(CH2)3CH3 -(CH2)2CH(CH3)2
549 -(CH2)3CH=CH-(CH2)2CH3 -(CH2)2CH(CH3)2
550 -(CH2)4CH=CH-CH2CH3 -(CH2)2CH(CH3)2
551 -(CH2)5CH=CH-CH3 -(CH2)2CH(CH3)2
552 -(CH2)6CH=CH2 -(CH2)2CH(CH3)2
553 -CH3 -CH2(CH2)4CH3
554 -CH2CH3 -CH2(CH2)4CH3
555 -CH2CH2CH3 -CH2(CH2)4CH3
556 -CH(CH3)2 -CH2(CH2)4CH3
557 -CH2CH2CH2CH3 -CH2(CH2)4CH3
558 -CH(CH3)CH2CH3 -CH2(CH2)4CH3
559 -CH2CH(CH3)2 -CH2(CH2)4CH3
560 -C(CH3)3 -CH2(CH2)4CH3
561 -CH2(CH2)3CH3 -CH2(CH2)4CH3
562 -CH(CH3)(CH2)2CH3 -CH2(CH2)4CH3
563 -CH2CH(CH3)CH2CH3 -CH2(CH2)4CH3
564 -(CH2)2CH(CH3)2 -CH2(CH2)4CH3
565 -CH2(CH2)4CH3 -CH2(CH2)4CH3
566 -CH2(CH2)5CH3 -CH2(CH2)4CH3
567 -CH2(CH2)6CH3 -CH2(CH2)4CH3
568 -CH=CH2 -CH2(CH2)4CH3
569 -CH=CHCH3 -CH2(CH2)4CH3
570 -CH=C(CH3)2 -CH2(CH2)4CH3
571 -C(CH3)=CH2 -CH2(CH2)4CH3
572 -C(CH3)=CHCH3 -CH2(CH2)4CH3
573 -C(CH3)=C(CH3)2 -CH2(CH2)4CH3
574 -CH=CH-CH2CH3 -CH2(CH2)4CH3
575 -CH2CH=CH-CH3 -CH2(CH2)4CH3
576 -(CH2)2CH=CH2 -CH2(CH2)4CH3
577 -CH=CH-(CH2)2CH3 -CH2(CH2)4CH3
578 -CH2CH=CH-CH2CH3 -CH2(CH2)4CH3
579 -(CH2)2CH=CH-CH3 -CH2(CH2)4CH3
580 -(CH2)3CH=CH2 -CH2(CH2)4CH3
581 -CH=CH-(CH2)3CH3 -CH2(CH2)4CH3
582 -CH2CH=CH-(CH2)2CH3 -CH2(CH2)4CH3
583 -(CH2)2CH=CH-CH2CH3 -CH2(CH2)4CH3
584 -(CH2)3CH=CH-CH3 -CH2(CH2)4CH3
585 -(CH2)4CH=CH2 -CH2(CH2)4CH3
586 -CH=CH-(CH2)3CH3 -CH2(CH2)4CH3
587 -CH2CH=CH-(CH2)3CH3 -CH2(CH2)4CH3
588 -(CH2)2CH=CH-(CH2)2CH3 -CH2(CH2)4CH3
589 -(CH2)3CH=CH-CH2CH3 -CH2(CH2)4CH3
590 -(CH2)4CH=CH-CH3 -CH2(CH2)4CH3
591 -(CH2)5CH=CH2 -CH2(CH2)4CH3
592 -CH=CH-(CH2)5CH3 -CH2(CH2)4CH3
593 -CH2CH=CH-(CH2)4CH3 -CH2(CH2)4CH3
594 -(CH2)2CH=CH-(CH2)3CH3 -CH2(CH2)4CH3
595 -(CH2)3CH=CH-(CH2)2CH3 -CH2(CH2)4CH3
596 -(CH2)4CH=CH-CH2CH3 -CH2(CH2)4CH3
597 -(CH2)5CH=CH-CH3 -CH2(CH2)4CH3
598 -(CH2)6CH=CH2 -CH2(CH2)4CH3
599 -CH3 -CH2(CH2)5CH3
600 -CH2CH3 -CH2(CH2)5CH3
601 -CH2CH2CH3 -CH2(CH2)5CH3
602 -CH(CH3)2 -CH2(CH2)sCH3
603 -CH2CH2CH2CH3 -CH2(CH2)5CH3
604 -CH(CH3)CH2CH3 -CH2(CH2)5CH3
605 -CH2CH(CH3)2 -CH2(CH2)5CH3
606 -C(CH3)3 -CH2(CH2)sCH3
607 -CH2(CH2)3CH3 -CH2(CH2)5CH3
608 -CH(CH3)(CH2)2CH3 -CH2(CH2)5CH3
609 -CH2CH(CH3)CH2CH3 -CH2(CH2)5CH3
610 -(CH2)2CH(CH3)2 -CH2(CH2)5CH3
611 -CH2(CH2)4CH3 -CH2(CH2)5CH3
612 -CH2(CH2)5CH3 -CH2(CH2)5CH3
613 -CH2(CH2)6CH3 -CH2(CH2)5CH3
614 -CH=CH2 -CH2(CH2)5CH3
615 -CH=CHCH3 -CH2(CH2)5CH3
616 -CH=C(CH3)2 -CH2(CH2)5CH3
617 -C(CH3)=CH2 -CH2(CH2)5CH3
618 -C(CH3)=CHCH3 -CH2(CH2)5CH3
619 -C(CH3)=C(CH3)2 -CH2(CH2)5CH3
620 -CH=CH-CH2CH3 -CH2(CH2)5CH3
621 -CH2CH=CH-CH3 -CH2(CH2)5CH3
622 -(CH2)2CH=CH2 -CH2(CH2)5CH3
623 -CH=CH-(CH2)2CH3 -CH2(CH2)5CH3
624 -CH2CH=CH-CH2CH3 -CH2(CH2)5CH3
625 -(CH2)2CH=CH-CH3 -CH2(CH2)5CH3
626 -(CH2)3CH=CH2 -CH2(CH2)5CH3
627 -CH=CH-(CH2)3CH3 -CH2(CH2)5CH3
628 -CH2CH=CH-(CH2)2CH3 -CH2(CH2)5CH3
629 -(CH2)2CH=CH-CH2CH3 -CH2(CH2)5CH3
630 -(CH2)3CH=CH-CH3 -CH2(CH2)5CH3
631 -(CH2)4CH=CH2 -CH2(CH2)5CH3
632 -CH=CH-(CH2)3CH3 -CH2(CH2)5CH3
633 -CH2CH=CH-(CH2)3CH3 -CH2(CH2)5CH3
634 -(CH2)2CH=CH-(CH2)2CH3 -CH2(CH2)5CH3
635 -(CH2)3CH=CH-CH2CH3 -CH2(CH2)5CH3
636 -(CH2)4CH=CH-CH3 -CH2(CH2)5CH3
637 -(CH2)5CH=CH2 -CH2(CH2)5CH3
638 -CH=CH-(CH2)5CH3 -CH2(CH2)5CH3
639 -CH2CH=CH-(CH2)4CH3 -CH2(CH2)5CH3
640 -(CH2)2CH=CH-(CH2)3CH3 -CH2(CH2)5CH3
641 -(CH2)3CH=CH-(CH2)2CH3 -CH2(CH2)5CH3
642 -(CH2)4CH=CH-CH2CH3 -CH2(CH2)5CH3
643 -(CH2)5CH=CH-CH3 -CH2(CH2)5CH3
644 -(CH2)6CH=CH2 -CH2(CH2)5CH3
645 -CH3 -CH2(CH2)6CH3
646 -CH2CH3 -CH2(CH2)6CH3
647 -CH2CH2CH3 -CH2(CH2)6CH3
648 -CH(CH3)2 -CH2(CH2)6CH3
649 -CH2CH2CH2CH3 -CH2(CH2)6CH3
650 -CH(CH3)CH2CH3 -CH2(CH2)6CH3
651 -CH2CH(CH3)2 -CH2(CH2)6CH3
652 -C(CH3)3 -CH2(CH2)6CH3
653 -CH2(CH2)3CH3 -CH2(CH2)6CH3
654 -CH(CH3)(CH2)2CH3 -CH2(CH2)6CH3
655 -CH2CH(CH3)CH2CH3 -CH2(CH2)6CH3
656 -(CH2)2CH(CH3)2 -CH2(CH2)6CH3
657 -CH2(CH2)4CH3 -CH2(CH2)6CH3
658 -CH2(CH2)5CH3 -CH2(CH2)6CH3
59 -CH2(CH2)6CH3 -CH2(CH2)6CH3
660 -CH=CH2 -CH2(CH2)6CH3
661 -CH=CHCH3 -CH2(CH2)6CH3
662 -CH=C(CH3)2 -CH2(CH2)6CH3
663 -C(CH3)=CH2 -CH2(CH2)6CH3
664 -C(CH3)=CHCH3 -CH2(CH2)6CH3
665 -C(CH3)=C(CH3)2 -CH2(CH2)6CH3
666 -CH=CH-CH2CH3 -CH2(CH2)6CH3
667 -CH2CH=CH-CH3 -CH2(CH2)6CH3
668 -(CH2)2CH=CH2 -CH2(CH2)6CH3
669 -CH=CH-(CH2)2CH3 -CH2(CH2)6CH3
670 -CH2CH=CH-CH2CH3 -CH2(CH2)6CH3
671 -(CH2)2CH=CH-CH3 -CH2(CH2)6CH3
672 -(CH2)3CH=CH2 -CH2(CH2)6CH3
673 -CH=CH-(CH2)3CH3 -CH2(CH2)6CH3
674 -CH2CH=CH-(CH2)2CH3 -CH2(CH2)6CH3
675 -(CH2)2CH=CH-CH2CH3 -CH2(CH2)6CH3
676 -(CH2)3CH=CH-CH3 -CH2(CH2)6CH3
677 -(CH2)4CH=CH2 -CH2(CH2)6CH3
678 -CH=CH-(CH2)3CH3 -CH2(CH2)6CH3
679 -CH2CH=CH-(CH2)3CH3 -CH2(CH2)6CH3
680 -(CH2)2CH=CH-(CH2)2CH3 -CH2(CH2)6CH3
681 -(CH2)3CH=CH-CH2CH3 -CH2(CH2)6CH3
682 -(CH2)4CH=CH-CH3 -CH2(CH2)6CH3
683 -(CH2)5CH=CH2 -CH2(CH2)6CH3
684 -CH=CH-(CH2)5CH3 -CH2(CH2)6CH3
685 -CH2CH=CH-(CH2)4CH3 -CH2(CH2)6CH3
686 -(CH2)2CH=CH-(CH2)3CH3 -CH2(CH2)6CH3
687 -(CH2)3CH=CH-(CH2)2CH3 -CH2(CH2)6CH3
688 -(CH2)4CH=CH-CH2CH3 -CH2(CH2)6CH3
689 -(CH2)5CH=CH-CH3 -CH2(CH2)6CH3
690 -(CH2)6CH=CH2 -CH2(CH2)6CH3
691 -CH3 -CH=CH2
692 -CH2CH3 -CH=CH2
693 -CH2CH2CH3 -CH=CH2
694 -CH(CH3)2 -CH=CH2
695 -CH2CH2CH2CH3 -CH=CH2
696 -CH(CH3)CH2CH3 -CH=CH2
697 -CH2CH(CH3)2 -CH=CH2
698 -C(CH3)3 -CH=CH2
699 -CH2(CH2)3CH3 -CH=CH2
700 -CH(CH3)(CH2)2CH3 -CH=CH2
701 -CH2CH(CH3)CH2CH3 -CH=CH2
702 -(CH2)2CH(CH3)2 -CH=CH2
703 -CH2(CH2)4CH3 -CH=CH2
704 -CH2(CH2)5CH3 -CH=CH2
705 -CH2(CH2)6CH3 -CH=CH2
706 -CH=CH2 -CH=CH2
707 -CH=CHCH3 -CH=CH2
708 -CH=C(CH3)2 -CH=CH2
709 -C(CH3)=CH2 -CH=CH2
710 -C(CH3)=CHCH3 -CH=CH2
711 -C(CH3)=C(CH3)2 -CH=CH2
712 -CH=CH-CH2CH3 -CH=CH2
713 -CH2CH=CH-CH3 -CH=CH2
714 -(CH2)2CH=CH2 -CH=CH2
715 -CH=CH-(CH2)2CH3 -CH=CH2
716 -CH2CH=CH-CH2CH3 -CH=CH2
717 -(CH2)2CH=CH-CH3 -CH=CH2
718 -(CH2)3CH=CH2 -CH=CH2
719 -CH=CH-(CH2)3CH3 -CH=CH2
720 -CH2CH=CH-(CH2)2CH3 -CH=CH2
721 -(CH2)2CH=CH-CH2CH3 -CH=CH2
722 -(CH2)3CH=CH-CH3 -CH=CH2
723 -(CH2)4CH=CH2 -CH=CH2
724 -CH=CH-(CH2)3CH3 -CH=CH2
725 -CH2CH=CH-(CH2)3CH3 -CH=CH2
726 -(CH2)2CH=CH-(CH2)2CH3 -CH=CH2
727 -(CH2)3CH=CH-CH2CH3 -CH=CH2
728 -(CH2)4CH=CH-CH3 -CH=CH2
729 -(CH2)5CH=CH2 -CH=CH2
730 -CH=CH-(CH2)5CH3 -CH=CH2
731 -CH2CH=CH-(CH2)4CH3 -CH=CH2
732 -(CH2)2CH=CH-(CH2)3CH3 -CH=CH2
733 -(CH2)3CH=CH-(CH2)2CH3 -CH=CH2
734 -(CH2)4CH=CH-CH2CH3 -CH=CH2
735 -(CH2)5CH=CH-CH3 -CH=CH2
736 -(CH2)6CH=CH2 -CH=CH2
737 -CH3 -C(CH3)=CH2
738 -CH2CH3 -C(CH3)=CH2
739 -CH2CH2CH3 -C(CH3)=CH2
740 -CH(CH3)2 -C(CH3)=CH2
741 -CH2CH2CH2CH3 -C(CH3)=CH2
742 -CH(CH3)CH2CH3 -C(CH3)=CH2
743 -CH2CH(CH3)2 -C(CH3)=CH2
744 -C(CH3)3 -C(CH3)=CH2
745 -CH2(CH2)3CH3 -C(CH3)=CH2
746 -CH(CH3)(CH2)2CH3 -C(CH3)=CH2
747 -CH2CH(CH3)CH2CH3 -C(CH3)=CH2
748 -(CH2)2CH(CH3)2 -C(CH3)=CH2
749 -CH2(CH2)4CH3 -C(CH3)=CH2
750 -CH2(CH2)5CH3 -C(CH3)=CH2
751 -CH2(CH2)6CH3 -C(CH3)=CH2
752 -CH=CH2 -C(CH3)=CH2
753 -CH=CHCH3 -C(CH3)=CH2
754 -CH=C(CH3)2 -C(CH3)=CH2
755 -C(CH3)=CH2 -C(CH3)=CH2
756 -C(CH3)=CHCH3 -C(CH3)=CH2
757 -C(CH3)=C(CH3)2 -C(CH3)=CH2
758 -CH=CH-CH2CH3 -C(CH3)=CH2
759 -CH2CH=CH-CH3 -C(CH3)=CH2
760 -(CH2)2CH=CH2 -C(CH3)=CH2
761 -CH=CH-(CH2)2CH3 -C(CH3)=CH2
762 -CH2CH=CH-CH2CH3 -C(CH3)=CH2
763 -(CH2)2CH=CH-CH3 -C(CH3)=CH2
764 -(CH2)3CH=CH2 -C(CH3)=CH2
765 -CH=CH-(CH2)3CH3 -C(CH3)=CH2
766 -CH2CH=CH-(CH2)2CH3 -C(CH3)=CH2
767 -(CH2)2CH=CH-CH2CH3 -C(CH3)=CH2
768 -(CH2)3CH=CH-CH3 -C(CH3)=CH2
769 -(CH2)4CH=CH2 -C(CH3)=CH2
770 -CH=CH-(CH2)3CH3 -C(CH3)=CH2
771 -CH2CH=CH-(CH2)3CH3 -C(CH3)=CH2
772 -(CH2)2CH=CH-(CH2)2CH3 -C(CH3)=CH2
773 -(CH2)3CH=CH-CH2CH3 -C(CH3)=CH2
774 -(CH2)4CH=CH-CH3 -C(CH3)=CH2
775 -(CH2)5CH=CH2 -C(CH3)=CH2
776 -CH=CH-(CH2)5CH3 -C(CH3)=CH2
777 -CH2CH=CH-(CH2)4CH3 -C(CH3)=CH2
778 -(CH2)2CH=CH-(CH2)3CH3 -C(CH3)=CH2
779 -(CH2)3CH=CH-(CH2)2CH3 -C(CH3)=CH2
780 -(CH2)4CH=CH-CH2CH3 -C(CH3)=CH2
781 -(CH2)5CH=CH-CH3 -C(CH3)=CH2
782 -(CH2)6CH=CH2 -C(CH3)=CH2
783 -CH3 -O-CH3
784 -CH2CH3 -O-CH3
785 -CH2CH2CH3 -O-CH3
786 -CH(CH3)2 -O-CH3
787 -CH2CH2CH2CH3 -O-CH3
788 -CH(CH3)CH2CH3 -O-CH3
789 -CH2CH(CH3)2 -O-CH3
790 -C(CH3)3 -O-CH3
791 -CH2(CH2)3CH3 -O-CH3
792 -CH(CH3)(CH2)2CH3 -O-CH3
793 -CH2CH(CH3)CH2CH3 -O-CH3
794 -(CH2)2CH(CH3)2 -O-CH3
795 -CH2(CH2)4CH3 -O-CH3
796 -CH2(CH2)5CH3 -O-CH3
797 -CH2(CH2)6CH3 -O-CH3
798 -CH=CH2 -O-CH3
799 -CH=CHCH3 -O-CH3
800 -CH=C(CH3)2 -O-CH3
801 -C(CH3)=CH2 -O-CH3
802 -C(CH3)=CHCH3 -O-CH3
803 -C(CH3)=C(CH3)2 -O-CH3
804 -CH=CH-CH2CH3 -O-CH3
805 -CH2CH=CH-CH3 -O-CH3
806 -(CH2)2CH=CH2 -O-CH3
807 -CH=CH-(CH2)2CH3 -O-CH3
808 -CH2CH=CH-CH2CH3 -O-CH3
809 -(CH2)2CH=CH-CH3 -O-CH3
810 -(CH2)3CH=CH2 -O-CH3
811 -CH=CH-(CH2)3CH3 -O-CH3
812 -CH2CH=CH-(CH2)2CH3 -O-CH3
813 -(CH2)2CH=CH-CH2CH3 -O-CH3
814 -(CH2)3CH=CH-CH3 -O-CH3
815 -(CH2)4CH=CH2 -O-CH3
816 -CH=CH-(CH2)3CH3 -O-CH3
817 -CH2CH=CH-(CH2)3CH3 -O-CH3
818 -(CH2)2CH=CH-(CH2)2CH3 -O-CH3
819 -(CH2)3CH=CH-CH2CH3 -O-CH3
820 -(CH2)4CH=CH-CH3 -O-CH3
821 -(CH2)5CH=CH2 -O-CH3
822 -CH=CH-(CH2)5CH3 -O-CH3
823 -CH2CH=CH-(CH2)4CH3 -O-CH3
824 -(CH2)2CH=CH-(CH2)3CH3 -O-CH3
825 -(CH2)3CH=CH-(CH2)2CH3 -O-CH3
826 -(CH2)4CH=CH-CH2CH3 -O-CH3
827 -(CH2)5CH=CH-CH3 -O-CH3
828 -(CH2)6CH=CH2 -O-CH3
829 -CH3 -O-CH2CH3
830 -CH2CH3 -O-CH2CH3
831 -CH2CH2CH3 -O-CH2CH3
832 -CH(CH3)2 -O-CH2CH3
833 -CH2CH2CH2CH3 -O-CH2CH3
834 -CH(CH3)CH2CH3 -O-CH2CH3
835 -CH2CH(CH3)2 -O-CH2CH3
836 -C(CH3)3 -O-CH2CH3
837 -CH2(CH2)3CH3 -O-CH2CH3
838 -CH(CH3)(CH2)2CH3 -O-CH2CH3
839 -CH2CH(CH3)CH2CH3 -O-CH2CH3
840 -(CH2)2CH(CH3)2 -O-CH2CH3
841 -CH2(CH2)4CH3 -O-CH2CH3
842 -CH2(CH2)5CH3 -O-CH2CH3
843 -CH2(CH2)6CH3 -O-CH2CH3
844 -CH=CH2 -O-CH2CH3
845 -CH=CHCH3 -O-CH2CH3
846 -CH=C(CH3)2 -O-CH2CH3
847 -C(CH3)=CH2 -O-CH2CH3
848 -C(CH3)=CHCH3 -O-CH2CH3
849 -C(CH3)=C(CH3)2 -O-CH2CH3
850 -CH=CH-CH2CH3 -O-CH2CH3
851 -CH2CH=CH-CH3 -O-CH2CH3
852 -(CH2)2CH=CH2 -O-CH2CH3
853 -CH=CH-(CH2)2CH3 -O-CH2CH3
854 -CH2CH=CH-CH2CH3 -O-CH2CH3
855 -(CH2)2CH=CH-CH3 -O-CH2CH3
856 -(CH2)3CH=CH2 -O-CH2CH3
857 -CH=CH-(CH2)3CH3 -O-CH2CH3
858 -CH2CH=CH-(CH2)2CH3 -O-CH2CH3
859 -(CH2)2CH=CH-CH2CH3 -O-CH2CH3
860 -(CH2)3CH=CH-CH3 -O-CH2CH3
861 -(CH2)4CH=CH2 -O-CH2CH3
862 -CH=CH-(CH2)3CH3 -O-CH2CH3
863 -CH2CH=CH-(CH2)3CH3 -O-CH2CH3
864 -(CH2)2CH=CH-(CH2)2CH3 -O-CH2CH3
865 -(CH2)3CH=CH-CH2CH3 -O-CH2CH3
866 -(CH2)4CH=CH-CH3 -O-CH2CH3
867 -(CH2)5CH=CH2 -O-CH2CH3
868 -CH=CH-(CH2)5CH3 -O-CH2CH3
869 -CH2CH=CH-(CH2)4CH3 -O-CH2CH3
870 -(CH2)2CH=CH-(CH2)3CH3 -O-CH2CH3
871 -(CH2)3CH=CH-(CH2)2CH3 -O-CH2CH3
872 -(CH2)4CH=CH-CH2CH3 -O-CH2CH3
873 -(CH2)5CH=CH-CH3 -O-CH2CH3
874 -(CH2)6CH=CH2 -O-CH2CH3
875 -CH3 -O-CH2CH2CH3
876 -CH2CH3 -O-CH2CH2CH3
877 -CH2CH2CH3 -O-CH2CH2CH3
878 -CH(CH3)2 -O-CH2CH2CH3
879 -CH2CH2CH2CH3 -O-CH2CH2CH3
880 -CH(CH3)CH2CH3 -O-CH2CH2CH3
881 -CH2CH(CH3)2 -O-CH2CH2CH3
882 -C(CH3)3 -O-CH2CH2CH3
883 -CH2(CH2)3CH3 -O-CH2CH2CH3
884 -CH(CH3)(CH2)2CH3 -O-CH2CH2CH3
885 -CH2CH(CH3)CH2CH3 -O-CH2CH2CH3
886 -(CH2)2CH(CH3)2 -O-CH2CH2CH3
887 -CH2(CH2)4CH3 -O-CH2CH2CH3
888 -CH2(CH2)5CH3 -O-CH2CH2CH3
889 -CH2(CH2)6CH3 -O-CH2CH2CH3
890 -CH=CH2 -O-CH2CH2CH3
891 -CH=CHCH3 -O-CH2CH2CH3
892 -CH=C(CH3)2 -O-CH2CH2CH3
893 -C(CH3)=CH2 -O-CH2CH2CH3
894 -C(CH3)=CHCH3 -O-CH2CH2CH3
895 -C(CH3)=C(CH3)2 -O-CH2CH2CH3
896 -CH=CH-CH2CH3 -O-CH2CH2CH3
897 -CH2CH=CH-CH3 -O-CH2CH2CH3
898 -(CH2)2CH=CH2 -O-CH2CH2CH3
899 -CH=CH-(CH2)2CH3 -O-CH2CH2CH3
900 -CH2CH=CH-CH2CH3 -O-CH2CH2CH3
901 -(CH2)2CH=CH-CH3 -O-CH2CH2CH3
902 -(CH2)3CH=CH2 -O-CH2CH2CH3
903 -CH=CH-(CH2)3CH3 -O-CH2CH2CH3
904 -CH2CH=CH-(CH2)2CH3 -O-CH2CH2CH3
905 -(CH2)2CH=CH-CH2CH3 -O-CH2CH2CH3
906 -(CH2)3CH=CH-CH3 -O-CH2CH2CH3
907 -(CH2)4CH=CH2 -O-CH2CH2CH3
908 -CH=CH-(CH2)3CH3 -O-CH2CH2CH3
909 -CH2CH=CH-(CH2)3CH3 -O-CH2CH2CH3
910 -(CH2)2CH=CH-(CH2)2CH3 -O-CH2CH2CH3
911 -(CH2)3CH=CH-CH2CH3 -O-CH2CH2CH3
912 -(CH2)4CH=CH-CH3 -O-CH2CH2CH3
913 -(CH2)5CH=CH2 -O-CH2CH2CH3
914 -CH=CH-(CH2)5CH3 -O-CH2CH2CH3
915 -CH2CH=CH-(CH2)4CH3 -O-CH2CH2CH3
916 -(CH2)2CH=CH-(CH2)3CH3 -O-CH2CH2CH3
917 -(CH2)3CH=CH-(CH2)2CH3 -O-CH2CH2CH3
918 -(CH2)4CH=CH-CH2CH3 -O-CH2CH2CH3
919 -(CH2)5CH=CH-CH3 -O-CH2CH2CH3
920 -(CH2)6CH=CH2 -O-CH2CH2CH3
921 -CH3 -O-CH(CH3)2
922 -CH2CH3 -O-CH(CH3)2
923 -CH2CH2CH3 -O-CH(CH3)2
924 -CH(CH3)2 -O-CH(CH3)2
925 -CH2CH2CH2CH3 -O-CH(CH3)2
926 -CH(CH3)CH2CH3 -O-CH(CH3)2
927 -CH2CH(CH3)2 -O-CH(CH3)2
928 -C(CH3)3 -O-CH(CH3)2
929 -CH2(CH2)3CH3 -O-CH(CH3)2
930 -CH(CH3)(CH2)2CH3 -O-CH(CH3)2
931 -CH2CH(CH3)CH2CH3 -O-CH(CH3)2
932 -(CH2)2CH(CH3)2 -O-CH(CH3)2
933 -CH2(CH2)4CH3 -O-CH(CH3)2
934 -CH2(CH2)5CH3 -O-CH(CH3)2
935 -CH2(CH2)6CH3 -O-CH(CH3)2
936 -CH=CH2 -O-CH(CH3)2
937 -CH=CHCH3 -O-CH(CH3)2
938 -CH=C(CH3)2 -O-CH(CH3)2
939 -C(CH3)=CH2 -O-CH(CH3)2
940 -C(CH3)=CHCH3 -O-CH(CH3)2
941 -C(CH3)=C(CH3)2 -O-CH(CH3)2
942 -CH=CH-CH2CH3 -O-CH(CH3)2
943 -CH2CH=CH-CH3 -O-CH(CH3)2
944 -(CH2)2CH=CH2 -O-CH(CH3)2
945 -CH=CH-(CH2)2CH3 -O-CH(CH3)2
946 -CH2CH=CH-CH2CH3 -O-CH(CH3)2
947 -(CH2)2CH=CH-CH3 -O-CH(CH3)2
948 -(CH2)3CH=CH2 -O-CH(CH3)2
949 -CH=CH-(CH2)3CH3 -O-CH(CH3)2
950 -CH2CH=CH-(CH2)2CH3 -O-CH(CH3)2
951 -(CH2)2CH=CH-CH2CH3 -O-CH(CH3)2
952 -(CH2)3CH=CH-CH3 -O-CH(CH3)2
953 -(CH2)4CH=CH2 -O-CH(CH3)2
954 -CH=CH-(CH2)3CH3 -O-CH(CH3)2
955 -CH2CH=CH-(CH2)3CH3 -O-CH(CH3)2
956 -(CH2)2CH=CH-(CH2)2CH3 -O-CH(CH3)2
957 -(CH2)3CH=CH-CH2CH3 -O-CH(CH3)2
958 -(CH2)4CH=CH-CH3 -O-CH(CH3)2
959 -(CH2)5CH=CH2 -O-CH(CH3)2
960 -CH=CH-(CH2)5CH3 -O-CH(CH3)2
961 -CH2CH=CH-(CH2)4CH3 -O-CH(CH3)2
962 -(CH2)2CH=CH-(CH2)3CH3 -O-CH(CH3)2
963 -(CH2)3CH=CH-(CH2)2CH3 -O-CH(CH3)2
964 -(CH2)4CH=CH-CH2CH3 -O-CH(CH3)2
965 -(CH2)5CH=CH-CH3 -O-CH(CH3)2
966 -(CH2)6CH=CH2 -O-CH(CH3)2
Individual species satisfying the above formula are listed in Table 2 below with respect to their R5 and R6 residues. These are particularly preferred according to the invention.
Table 2: Preferred phenyl esters No. R5 R6
1 -CH 3 -CH 3
2 -CH 2 CH 3 -CH 3
3 -CH 2 CH 2 CH 3 -CH 3
4 -CH (CH 3 ) 2 -CH 3
5 -CH 2 CH 2 CH 2 CH 3 -CH 3
6 -CH (CH 3 ) CH 2 CH 3 -CH 3
7 -CH 2 CH (CH 3 ) 2 -CH 3
8th -C (CH 3 ) 3 -CH 3
9 -CH 2 (CH 2 ) 3 CH 3 -CH 3
10 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 3
11 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 3
12 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 3
13 -CH 2 (CH 2 ) 4 CH 3 -CH 3
14 -CH 2 (CH 2 ) 5 CH 3 -CH 3
15 -CH 2 (CH 2 ) 6 CH 3 -CH 3
16 -CH = CH 2 -CH 3
17 -CH = CHCH 3 -CH 3
18 -CH = C (CH 3 ) 2 -CH 3
19 -C (CH 3 ) = CH 2 -CH 3
20 -C (CH 3 ) = CHCH 3 -CH 3
21 -C (CH 3 ) = C (CH 3 ) 2 -CH 3
22 -CH = CH-CH 2 CH 3 -CH 3
23 -CH 2 CH = CH-CH 3 -CH 3
24 - (CH 2 ) 2 CH = CH 2 -CH 3
25 -CH = CH- (CH 2 ) 2 CH 3 -CH 3
26 -CH 2 CH = CH-CH 2 CH 3 -CH 3
27 - (CH 2 ) 2 CH = CH-CH 3 -CH 3
28 - (CH 2 ) 3 CH = CH 2 -CH 3
29 -CH = CH- (CH 2 ) 3 CH 3 -CH 3
30 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 3
31 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 3
32 - (CH 2 ) 3 CH = CH-CH 3 -CH 3
33 - (CH 2 ) 4 CH = CH 2 -CH 3
34 -CH = CH- (CH 2 ) 3 CH 3 -CH 3
35 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 3
36 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 3
37 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 3
38 - (CH 2 ) 4 CH = CH-CH 3 -CH 3
39 - (CH 2 ) 5 CH = CH 2 -CH 3
40 -CH = CH- (CH 2 ) 5 CH 3 -CH 3
41 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 3
42 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 3
43 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 3
44 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 3
45 - (CH 2 ) 5 CH = CH-CH 3 -CH 3
46 - (CH 2 ) 6 CH = CH 2 -CH 3
47 -CH 3 -CH 2 CH 3
48 -CH 2 CH 3 -CH 2 CH 3
49 -CH 2 CH 2 CH 3 -CH 2 CH 3
50 -CH (CH 3 ) 2 -CH 2 CH 3
51 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3
52 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3
53 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3
54 -C (CH 3 ) 3 -CH 2 CH 3
55 -CH 2 (CH 2 ) 3 CH 3 -CH 2 CH 3
56 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 CH 3
57 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3
58 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 CH 3
59 -CH 2 (CH 2 ) 4 CH 3 -CH 2 CH 3
60 -CH 2 (CH 2 ) s CH 3 -CH 2 CH 3
61 -CH 2 (CH 2 ) 6 CH 3 -CH 2 CH 3
62 -CH = CH 2 -CH 2 CH 3
63 -CH = CHCH 3 -CH 2 CH 3
64 -CH = C (CH 3 ) 2 -CH 2 CH 3
65 -C (CH 3 ) = CH 2 -CH 2 CH 3
66 -C (CH 3 ) = CHCH 3 -CH 2 CH 3
67 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 CH 3
68 -CH = CH-CH 2 CH 3 -CH 2 CH 3
69 -CH 2 CH = CH-CH 3 -CH 2 CH 3
70 - (CH 2 ) 2 CH = CH 2 -CH 2 CH 3
71 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 3
72 -CH 2 CH = CH-CH 2 CH 3 -CH 2 CH 3
73 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 CH 3
74 - (CH 2 ) 3 CH = CH 2 -CH 2 CH 3
75 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 3
76 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 3
77 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 CH 3
78 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 CH 3
79 - (CH 2 ) 4 CH = CH 2 -CH 2 CH 3
80 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 3
81 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 3
82 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 3
83 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 CH 3
84 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 CH 3
85 - (CH 2 ) 5 CH = CH 2 -CH 2 CH 3
86 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 CH 3
87 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 CH 3
88 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 3
89 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 3
90 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 CH 3
91 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 CH 3
92 - (CH 2 ) 6 CH = CH 2 -CH 2 CH 3
93 -CH 3 -CH 2 CH 2 CH 3
94 -CH 2 CH 3 -CH 2 CH 2 CH 3
95 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
96 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
97 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
98 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3
99 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3
100 -C (CH 3 ) 3 -CH 2 CH 2 CH 3
101 -CH 2 (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 3
102 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 3
103 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3
104 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3
105 -CH 2 (CH 2 ) 4 CH 3 -CH 2 CH 2 CH 3
106 -CH 2 (CH 2 ) 5 CH 3 -CH 2 CH 2 CH 3
107 -CH 2 (CH 2 ) 6 CH 3 -CH 2 CH 2 CH 3
108 -CH = CH 2 -CH 2 CH 2 CH 3
109 -CH = CHCH 3 -CH 2 CH 2 CH 3
110 -CH = C (CH 3 ) 2 -CH 2 CH 2 CH 3
111 -C (CH 3 ) = CH 2 -CH 2 CH 2 CH 3
112 -C (CH 3 ) = CHCH 3 -CH 2 CH 2 CH 3
113 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 CH 2 CH 3
114 -CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 3
115 -CH 2 CH = CH-CH 3 -CH 2 CH 2 CH 3
116 - (CH 2 ) 2 CH = CH 2 -CH 2 CH 2 CH 3
117 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 3
118 -CH 2 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 3
119 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 CH 2 CH 3
120 - (CH 2 ) 3 CH = CH 2 -CH 2 CH 2 CH 3
121 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 3
122 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 3
123 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 3
124 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 CH 2 CH 3
125 - (CH 2 ) 4 CH = CH 2 -CH 2 CH 2 CH 3
126 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 3
127 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 3
128 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 3
129 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 3
130 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 CH 2 CH 3
131 - (CH 2 ) 5 CH = CH 2 -CH 2 CH 2 CH 3
132 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 CH 2 CH 3
133 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 CH 2 CH 3
134 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 3
135 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 3
136 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 3
137 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 CH 2 CH 3
138 - (CH 2 ) 6 CH = CH 2 -CH 2 CH 2 CH 3
139 -CH 3 -CH (CH 3 ) 2
140 -CH 2 CH 3 -CH (CH 3 ) 2
141 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2
142 -CH (CH 3 ) 2 -CH (CH 3 ) 2
143 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2
144 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2
145 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2
146 -C (CH 3 ) 3 -CH (CH 3 ) 2
147 -CH 2 (CH 2 ) 3 CH 3 -CH (CH 3 ) 2
148 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH (CH 3 ) 2
149 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2
150 - (CH 2 ) 2 CH (CH 3 ) 2 -CH (CH 3 ) 2
151 -CH 2 (CH 2 ) 4 CH 3 -CH (CH 3 ) 2
152 -CH 2 (CH 2 ) 5 CH 3 -CH (CH 3 ) 2
153 -CH 2 (CH 2 ) 6 CH 3 -CH (CH 3 ) 2
154 -CH = CH 2 -CH (CH 3 ) 2
155 -CH = CHCH 3 -CH (CH 3 ) 2
156 -CH = C (CH 3 ) 2 -CH (CH 3 ) 2
157 -C (CH 3 ) = CH 2 -CH (CH 3 ) 2
158 -C (CH 3 ) = CHCH 3 -CH (CH 3 ) 2
159 -C (CH 3 ) = C (CH 3 ) 2 -CH (CH 3 ) 2
160 -CH = CH-CH 2 CH 3 -CH (CH 3 ) 2
161 -CH 2 CH = CH-CH 3 -CH (CH 3 ) 2
162 - (CH 2 ) 2 CH = CH 2 -CH (CH 3 ) 2
163 -CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) 2
164 -CH 2 CH = CH-CH 2 CH 3 -CH (CH 3 ) 2
165 - (CH 2 ) 2 CH = CH-CH 3 -CH (CH 3 ) 2
166 - (CH 2 ) 3 CH = CH 2 -CH (CH 3 ) 2
167 -CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) 2
168 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) 2
169 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH (CH 3 ) 2
170 - (CH 2 ) 3 CH = CH-CH 3 -CH (CH 3 ) 2
171 - (CH 2 ) 4 CH = CH 2 -CH (CH 3 ) 2
172 -CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) 2
173 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) 2
174 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) 2
175 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH (CH 3 ) 2
176 - (CH 2 ) 4 CH = CH-CH 3 -CH (CH 3 ) 2
177 - (CH 2 ) 5 CH = CH 2 -CH (CH 3 ) 2
178 -CH = CH- (CH 2 ) 5 CH 3 -CH (CH 3 ) 2
179 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH (CH 3 ) 2
180 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) 2
181 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) 2
182 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH (CH 3 ) 2
183 - (CH 2 ) 5 CH = CH-CH 3 -CH (CH 3 ) 2
184 - (CH 2 ) 6 CH = CH 2 -CH (CH 3 ) 2
185 -CH 3 -CH 2 CH 2 CH 2 CH 3
186 -CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
187 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
188 -CH (CH 3 ) 2 -CH 2 CH 2 CH 2 CH 3
189 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
190 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
191 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 2 CH 3
192 -C (CH 3 ) 3 -CH 2 CH 2 CH 2 CH 3
193 -CH 2 (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 2 CH 3
194 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 2 CH 3
195 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
196 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 2 CH 3
197 -CH 2 (CH 2 ) 4 CH 3 -CH 2 CH 2 CH 2 CH 3
198 -CH 2 (CH 2 ) 5 CH 3 -CH 2 CH 2 CH 2 CH 3
199 -CH 2 (CH 2 ) 6 CH 3 -CH 2 CH 2 CH 2 CH 3
200 -CH = CH 2 -CH 2 CH 2 CH 2 CH 3
201 -CH = CHCH 3 -CH 2 CH 2 CH 2 CH 3
202 -CH = C (CH 3 ) 2 -CH 2 CH 2 CH 2 CH 3
203 -C (CH 3 ) = CH 2 -CH 2 CH 2 CH 2 CH 3
204 -C (CH 3 ) = CHCH 3 -CH 2 CH 2 CH 2 CH 3
205 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 CH 2 CH 2 CH 3
206 -CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
207 -CH 2 CH = CH-CH 3 -CH 2 CH 2 CH 2 CH 3
208 - (CH 2 ) 2 CH = CH 2 -CH 2 CH 2 CH 2 CH 3
209 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 2 CH 3
210 -CH 2 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
211 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 CH 2 CH 2 CH 3
212 - (CH 2 ) 3 CH = CH 2 -CH 2 CH 2 CH 2 CH 3
213 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 2 CH 3
214 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 2 CH 3
215 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
216 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 CH 2 CH 2 CH 3
217 - (CH 2 ) 4 CH = CH 2 -CH 2 CH 2 CH 2 CH 3
218 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 2 CH 3
219 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 2 CH 3
220 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 2 CH 3
221 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
222 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 CH 2 CH 2 CH 3
223 - (CH 2 ) 5 CH = CH 2 -CH 2 CH 2 CH 2 CH 3
224 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 CH 2 CH 2 CH 3
225 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 CH 2 CH 2 CH 3
226 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH 2 CH 2 CH 3
227 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH 2 CH 2 CH 3
228 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3
229 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 CH 2 CH 2 CH 3
230 - (CH 2 ) 6 CH = CH 2 -CH 2 CH 2 CH 2 CH 3
231 -CH 3 -CH (CH 3 ) CH 2 CH 3
232 -CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
233 -CH 2 CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
234 -CH (CH 3 ) 2 -CH (CH 3 ) CH 2 CH 3
235 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
236 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
237 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) CH 2 CH 3
238 -C (CH 3 ) 3 -CH (CH 3 ) CH 2 CH 3
239 -CH 2 (CH 2 ) 3 CH 3 -CH (CH 3 ) CH 2 CH 3
240 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH (CH 3 ) CH 2 CH 3
241 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
242 - (CH 2 ) 2 CH (CH 3 ) 2 -CH (CH 3 ) CH 2 CH 3
243 -CH 2 (CH 2 ) 4 CH 3 -CH (CH 3 ) CH 2 CH 3
244 -CH 2 (CH 2 ) 5 CH 3 -CH (CH 3 ) CH 2 CH 3
245 -CH 2 (CH 2 ) 6 CH 3 -CH (CH 3 ) CH 2 CH 3
246 -CH = CH 2 -CH (CH 3 ) CH 2 CH 3
247 -CH = CHCH 3 -CH (CH 3 ) CH 2 CH 3
248 -CH = C (CH 3 ) 2 -CH (CH 3 ) CH 2 CH 3
249 -C (CH 3 ) = CH 2 -CH (CH 3 ) CH 2 CH 3
250 -C (CH 3 ) = CHCH 3 -CH (CH 3 ) CH 2 CH 3
251 -C (CH 3 ) = C (CH 3 ) 2 -CH (CH 3 ) CH 2 CH 3
252 -CH = CH-CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
253 -CH 2 CH = CH-CH 3 -CH (CH 3 ) CH 2 CH 3
254 - (CH 2 ) 2 CH = CH 2 -CH (CH 3 ) CH 2 CH 3
255 -CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) CH 2 CH 3
256 -CH 2 CH = CH-CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
257 - (CH 2 ) 2 CH = CH-CH 3 -CH (CH 3 ) CH 2 CH 3
258 - (CH 2 ) 3 CH = CH 2 -CH (CH 3 ) CH 2 CH 3
259 -CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) CH 2 CH 3
260 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) CH 2 CH 3
261 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
262 - (CH 2 ) 3 CH = CH-CH 3 -CH (CH 3 ) CH 2 CH 3
263 - (CH 2 ) 4 CH = CH 2 -CH (CH 3 ) CH 2 CH 3
264 -CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) CH 2 CH 3
265 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) CH 2 CH 3
266 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) CH 2 CH 3
267 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
268 - (CH 2 ) 4 CH = CH-CH 3 -CH (CH 3 ) CH 2 CH 3
269 - (CH 2 ) 5 CH = CH 2 -CH (CH 3 ) CH 2 CH 3
270 -CH = CH- (CH 2 ) 5 CH 3 -CH (CH 3 ) CH 2 CH 3
271 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH (CH 3 ) CH 2 CH 3
272 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) CH 2 CH 3
273 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) CH 2 CH 3
274 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3
275 - (CH 2 ) 5 CH = CH-CH 3 -CH (CH 3 ) CH 2 CH 3
276 - (CH 2 ) 6 CH = CH 2 -CH (CH 3 ) CH 2 CH 3
277 -CH 3 -CH 2 CH (CH 3 ) 2
278 -CH 2 CH 3 -CH 2 CH (CH 3 ) 2
279 -CH 2 CH 2 CH 3 -CH 2 CH (CH 3 ) 2
280 -CH (CH 3 ) 2 -CH 2 CH (CH 3 ) 2
281 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH (CH 3 ) 2
282 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH (CH 3 ) 2
283 -CH 2 CH (CH 3 ) 2 -CH 2 CH (CH 3 ) 2
284 -C (CH 3 ) 3 -CH 2 CH (CH 3 ) 2
285 -CH 2 (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) 2
286 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) 2
287 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 CH (CH 3 ) 2
288 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 CH (CH 3 ) 2
289 -CH 2 (CH 2 ) 4 CH 3 -CH 2 CH (CH 3 ) 2
290 -CH 2 (CH 2 ) 5 CH 3 -CH 2 CH (CH 3 ) 2
291 -CH 2 (CH 2 ) 6 CH 3 -CH 2 CH (CH 3 ) 2
292 -CH = CH 2 -CH 2 CH (CH 3 ) 2
293 -CH = CHCH 3 -CH 2 CH (CH 3 ) 2
294 -CH = C (CH 3 ) 2 -CH 2 CH (CH 3 ) 2
295 -C (CH 3 ) = CH 2 -CH 2 CH (CH 3 ) 2
296 -C (CH 3 ) = CHCH 3 -CH 2 CH (CH 3 ) 2
297 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 CH (CH 3 ) 2
298 -CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) 2
299 -CH 2 CH = CH-CH 3 -CH 2 CH (CH 3 ) 2
300 - (CH 2 ) 2 CH = CH 2 -CH 2 CH (CH 3 ) 2
301 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) 2
302 -CH 2 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) 2
303 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 CH (CH 3 ) 2
304 - (CH 2 ) 3 CH = CH 2 -CH 2 CH (CH 3 ) 2
305 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) 2
306 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) 2
307 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) 2
308 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 CH (CH 3 ) 2
309 - (CH 2 ) 4 CH = CH 2 -CH 2 CH (CH 3 ) 2
310 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) 2
311 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) 2
312 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) 2
313 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) 2
314 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 CH (CH 3 ) 2
315 - (CH 2 ) 5 CH = CH 2 -CH 2 CH (CH 3 ) 2
316 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 CH (CH 3 ) 2
317 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 CH (CH 3 ) 2
318 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) 2
319 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) 2
320 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) 2
321 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 CH (CH 3 ) 2
322 - (CH 2 ) 6 CH = CH 2 -CH 2 CH (CH 3 ) 2
323 -CH 3 -C (CH 3 ) 3
324 -CH 2 CH 3 -C (CH 3 ) 3
325 -CH 2 CH 2 CH 3 -C (CH 3 ) 3
326 -CH (CH 3 ) 2 -C (CH 3 ) 3
327 -CH 2 CH 2 CH 2 CH 3 -C (CH 3 ) 3
328 -CH (CH 3 ) CH 2 CH 3 -C (CH 3 ) 3
329 -CH 2 CH (CH 3 ) 2 -C (CH 3 ) 3
330 -C (CH 3 ) 3 -C (CH 3 ) 3
331 -CH 2 (CH 2 ) 3 CH 3 -C (CH 3 ) 3
332 -CH (CH 3 ) (CH 2 ) 2 CH 3 -C (CH 3 ) 3
333 -CH 2 CH (CH 3 ) CH 2 CH 3 -C (CH 3 ) 3
334 - (CH 2 ) 2 CH (CH 3 ) 2 -C (CH 3 ) 3
335 -CH 2 (CH 2 ) 4 CH 3 -C (CH 3 ) 3
336 -CH 2 (CH 2 ) s CH 3 -C (CH 3 ) 3
337 -CH 2 (CH 2 ) 6 CH 3 -C (CH 3 ) 3
338 -CH = CH 2 -C (CH 3 ) 3
339 -CH = CHCH 3 -C (CH 3 ) 3
340 -CH = C (CH 3 ) 2 -C (CH 3 ) 3
341 -C (CH 3 ) = CH 2 -C (CH 3 ) 3
342 -C (CH 3 ) = CHCH 3 -C (CH 3 ) 3
343 -C (CH 3 ) = C (CH 3 ) 2 -C (CH 3 ) 3
344 -CH = CH-CH 2 CH 3 -C (CH 3 ) 3
345 -CH 2 CH = CH-CH 3 -C (CH 3 ) 3
346 - (CH 2 ) 2 CH = CH 2 -C (CH 3 ) 3
347 -CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) 3
348 -CH 2 CH = CH-CH 2 CH 3 -C (CH 3 ) 3
349 - (CH 2 ) 2 CH = CH-CH 3 -C (CH 3 ) 3
350 - (CH 2 ) 3 CH = CH 2 -C (CH 3 ) 3
351 -CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) 3
352 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) 3
353 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -C (CH 3 ) 3
354 - (CH 2 ) 3 CH = CH-CH 3 -C (CH 3 ) 3
355 - (CH 2 ) 4 CH = CH 2 -C (CH 3 ) 3
356 -CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) 3
357 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) 3
358 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) 3
359 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -C (CH 3 ) 3
360 - (CH 2 ) 4 CH = CH-CH 3 -C (CH 3 ) 3
361 - (CH 2 ) 5 CH = CH 2 -C (CH 3 ) 3
362 -CH = CH- (CH 2 ) 5 CH 3 -C (CH 3 ) 3
363 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -C (CH 3 ) 3
364 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) 3
365 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) 3
366 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -C (CH 3 ) 3
367 - (CH 2 ) 5 CH = CH-CH 3 -C (CH 3 ) 3
368 - (CH 2 ) 6 CH = CH 2 -C (CH 3 ) 3
369 -CH 3 -CH 2 (CH 2 ) 3 CH 3
370 -CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
371 -CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
372 -CH (CH 3 ) 2 -CH 2 (CH 2 ) 3 CH 3
373 -CH 2 CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
374 -CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
375 -CH 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 3 CH 3
376 -C (CH 3 ) 3 -CH 2 (CH 2 ) 3 CH 3
377 -CH 2 (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 3 CH 3
378 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
379 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
380 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 3 CH 3
381 -CH 2 (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 3 CH 3
382 -CH 2 (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 3 CH 3
383 -CH 2 (CH 2 ) 6 CH 3 -CH 2 (CH 2 ) 3 CH 3
384 -CH = CH 2 -CH 2 (CH 2 ) 3 CH 3
385 -CH = CHCH 3 -CH 2 (CH 2 ) 3 CH 3
386 -CH = C (CH 3 ) 2 -CH 2 (CH 2 ) 3 CH 3
387 -C (CH 3 ) = CH 2 -CH 2 (CH 2 ) 3 CH 3
388 -C (CH 3 ) = CHCH 3 -CH 2 (CH 2 ) 3 CH 3
389 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 (CH 2 ) 3 CH 3
390 -CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
391 -CH 2 CH = CH-CH 3 -CH 2 (CH 2 ) 3 CH 3
392 - (CH 2 ) 2 CH = CH 2 -CH 2 (CH 2 ) 3 CH 3
393 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
394 -CH 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
395 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 (CH 2 ) 3 CH 3
396 - (CH 2 ) 3 CH = CH 2 -CH 2 (CH 2 ) 3 CH 3
397 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 3 CH 3
398 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
399 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
400 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 (CH 2 ) 3 CH 3
401 - (CH 2 ) 4 CH = CH 2 -CH 2 (CH 2 ) 3 CH 3
402 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 3 CH 3
403 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 3 CH 3
404 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
405 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
406 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 (CH 2 ) 3 CH 3
407 - (CH 2 ) 5 CH = CH 2 -CH 2 (CH 2 ) 3 CH 3
408 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 3 CH 3
409 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 3 CH 3
410 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 3 CH 3
411 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
412 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 3 CH 3
413 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 (CH 2 ) 3 CH 3
414 - (CH 2 ) 6 CH = CH 2 -CH 2 (CH 2 ) 3 CH 3
415 -CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
416 -CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
417 -CH 2 CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
418 -CH (CH 3 ) 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
419 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
420 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
421 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
422 -C (CH 3 ) 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
423 -CH 2 (CH 2 ) 3 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
424 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
425 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
426 - (CH 2 ) 2 CH (CH 3 ) 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
427 -CH 2 (CH 2 ) 4 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
428 -CH 2 (CH 2 ) 5 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
429 -CH 2 (CH 2 ) 6 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
430 -CH = CH 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
431 -CH = CHCH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
432 -CH = C (CH 3 ) 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
433 -C (CH 3 ) = CH 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
434 -C (CH 3 ) = CHCH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
435 -C (CH 3 ) = C (CH 3 ) 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
436 -CH = CH-CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
437 -CH 2 CH = CH-CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
438 - (CH 2 ) 2 CH = CH 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
439 -CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
440 -CH 2 CH = CH-CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
441 - (CH 2 ) 2 CH = CH-CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
442 - (CH 2 ) 3 CH = CH 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
443 -CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
444 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
445 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
446 - (CH 2 ) 3 CH = CH-CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
447 - (CH 2 ) 4 CH = CH 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
448 -CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
449 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
450 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
451 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
452 - (CH 2 ) 4 CH = CH-CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
453 - (CH 2 ) 5 CH = CH 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
454 -CH = CH- (CH 2 ) 5 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
455 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
456 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
457 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
458 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
459 - (CH 2 ) 5 CH = CH-CH 3 -CH (CH 3 ) (CH 2 ) 2 CH 3
460 - (CH 2 ) 6 CH = CH 2 -CH (CH 3 ) (CH 2 ) 2 CH 3
461 -CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
462 -CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
463 -CH 2 CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
464 -CH (CH 3 ) 2 -CH 2 CH (CH 3 ) CH 2 CH 3
465 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
466 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
467 -CH 2 CH (CH 3 ) 2 -CH 2 CH (CH 3 ) CH 2 CH 3
468 -C (CH 3 ) 3 -CH 2 CH (CH 3 ) CH 2 CH 3
469 -CH 2 (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
470 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
471 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
472 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 CH (CH 3 ) CH 2 CH 3
473 -CH 2 (CH 2 ) 4 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
474 -CH 2 (CH 2 ) 5 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
475 -CH 2 (CH 2 ) 6 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
476 -CH = CH 2 -CH 2 CH (CH 3 ) CH 2 CH 3
477 -CH = CHCH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
478 -CH = C (CH 3 ) 2 -CH 2 CH (CH 3 ) CH 2 CH 3
479 -C (CH 3 ) = CH 2 -CH 2 CH (CH 3 ) CH 2 CH 3
480 -C (CH 3 ) = CHCH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
481 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 CH (CH 3 ) CH 2 CH 3
482 -CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
483 -CH 2 CH = CH-CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
484 - (CH 2 ) 2 CH = CH 2 -CH 2 CH (CH 3 ) CH 2 CH 3
485 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
486 -CH 2 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
487 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
488 - (CH 2 ) 3 CH = CH 2 -CH 2 CH (CH 3 ) CH 2 CH 3
489 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
490 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
491 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
492 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
493 - (CH 2 ) 4 CH = CH 2 -CH 2 CH (CH 3 ) CH 2 CH 3
494 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
495 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
496 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
497 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
498 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
499 - (CH 2 ) 5 CH = CH 2 -CH 2 CH (CH 3 ) CH 2 CH 3
500 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
501 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
502 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
503 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
504 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
505 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 CH (CH 3 ) CH 2 CH 3
506 - (CH 2 ) 6 CH = CH 2 -CH 2 CH (CH 3 ) CH 2 CH 3
507 -CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
508 -CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
509 -CH 2 CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
510 -CH (CH 3 ) 2 - (CH 2 ) 2 CH (CH 3 ) 2
511 -CH 2 CH 2 CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
512 -CH (CH 3 ) CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
513 -CH 2 CH (CH 3 ) 2 - (CH 2 ) 2 CH (CH 3 ) 2
514 -C (CH 3 ) 3 - (CH 2 ) 2 CH (CH 3 ) 2
515 -CH 2 (CH 2 ) 3 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
516 -CH (CH 3 ) (CH 2 ) 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
517 -CH 2 CH (CH 3 ) CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
518 - (CH 2 ) 2 CH (CH 3 ) 2 - (CH 2 ) 2 CH (CH 3 ) 2
519 -CH 2 (CH 2 ) 4 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
520 -CH 2 (CH 2 ) 5 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
521 -CH 2 (CH 2 ) 6 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
522 -CH = CH 2 - (CH 2 ) 2 CH (CH 3 ) 2
523 -CH = CHCH 3 - (CH 2 ) 2 CH (CH 3 ) 2
524 -CH = C (CH 3 ) 2 - (CH 2 ) 2 CH (CH 3 ) 2
525 -C (CH 3 ) = CH 2 - (CH 2 ) 2 CH (CH 3 ) 2
526 -C (CH 3 ) = CHCH 3 - (CH 2 ) 2 CH (CH 3 ) 2
527 -C (CH 3 ) = C (CH 3 ) 2 - (CH 2 ) 2 CH (CH 3 ) 2
528 -CH = CH-CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
529 -CH 2 CH = CH-CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
530 - (CH 2 ) 2 CH = CH 2 - (CH 2 ) 2 CH (CH 3 ) 2
531 -CH = CH- (CH 2 ) 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
532 -CH 2 CH = CH-CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
533 - (CH 2 ) 2 CH = CH-CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
534 - (CH 2 ) 3 CH = CH 2 - (CH 2 ) 2 CH (CH 3 ) 2
535 -CH = CH- (CH 2 ) 3 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
536 -CH 2 CH = CH- (CH 2 ) 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
537 - (CH 2 ) 2 CH = CH-CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
538 - (CH 2 ) 3 CH = CH-CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
539 - (CH 2 ) 4 CH = CH 2 - (CH 2 ) 2 CH (CH 3 ) 2
540 -CH = CH- (CH 2 ) 3 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
541 -CH 2 CH = CH- (CH 2 ) 3 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
542 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
543 - (CH 2 ) 3 CH = CH-CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
544 - (CH 2 ) 4 CH = CH-CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
545 - (CH 2 ) 5 CH = CH 2 - (CH 2 ) 2 CH (CH 3 ) 2
546 -CH = CH- (CH 2 ) 5 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
547 -CH 2 CH = CH- (CH 2 ) 4 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
548 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
549 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
550 - (CH 2 ) 4 CH = CH-CH 2 CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
551 - (CH 2 ) 5 CH = CH-CH 3 - (CH 2 ) 2 CH (CH 3 ) 2
552 - (CH 2 ) 6 CH = CH 2 - (CH 2 ) 2 CH (CH 3 ) 2
553 -CH 3 -CH 2 (CH 2 ) 4 CH 3
554 -CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
555 -CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
556 -CH (CH 3 ) 2 -CH 2 (CH 2 ) 4 CH 3
557 -CH 2 CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
558 -CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
559 -CH 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 4 CH 3
560 -C (CH 3 ) 3 -CH 2 (CH 2 ) 4 CH 3
561 -CH 2 (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 4 CH 3
562 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
563 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
564 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 4 CH 3
565 -CH 2 (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 4 CH 3
566 -CH 2 (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 4 CH 3
567 -CH 2 (CH 2 ) 6 CH 3 -CH 2 (CH 2 ) 4 CH 3
568 -CH = CH 2 -CH 2 (CH 2 ) 4 CH 3
569 -CH = CHCH 3 -CH 2 (CH 2 ) 4 CH 3
570 -CH = C (CH 3 ) 2 -CH 2 (CH 2 ) 4 CH 3
571 -C (CH 3 ) = CH 2 -CH 2 (CH 2 ) 4 CH 3
572 -C (CH 3 ) = CHCH 3 -CH 2 (CH 2 ) 4 CH 3
573 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 (CH 2 ) 4 CH 3
574 -CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
575 -CH 2 CH = CH-CH 3 -CH 2 (CH 2 ) 4 CH 3
576 - (CH 2 ) 2 CH = CH 2 -CH 2 (CH 2 ) 4 CH 3
577 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
578 -CH 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
579 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 (CH 2 ) 4 CH 3
580 - (CH 2 ) 3 CH = CH 2 -CH 2 (CH 2 ) 4 CH 3
581 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 4 CH 3
582 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
583 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
584 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 (CH 2 ) 4 CH 3
585 - (CH 2 ) 4 CH = CH 2 -CH 2 (CH 2 ) 4 CH 3
586 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 4 CH 3
587 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 4 CH 3
588 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
589 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
590 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 (CH 2 ) 4 CH 3
591 - (CH 2 ) 5 CH = CH 2 -CH 2 (CH 2 ) 4 CH 3
592 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 4 CH 3
593 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 4 CH 3
594 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 4 CH 3
595 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
596 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 4 CH 3
597 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 (CH 2 ) 4 CH 3
598 - (CH 2 ) 6 CH = CH 2 -CH 2 (CH 2 ) 4 CH 3
599 -CH 3 -CH 2 (CH 2 ) 5 CH 3
600 -CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
601 -CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
602 -CH (CH 3 ) 2 -CH 2 (CH 2 ) s CH 3
603 -CH 2 CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
604 -CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
605 -CH 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 5 CH 3
606 -C (CH 3 ) 3 -CH 2 (CH 2 ) sCH 3
607 -CH 2 (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 5 CH 3
608 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
609 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
610 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 5 CH 3
611 -CH 2 (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 5 CH 3
612 -CH 2 (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 5 CH 3
613 -CH 2 (CH 2 ) 6 CH 3 -CH 2 (CH 2 ) 5 CH 3
614 -CH = CH 2 -CH 2 (CH 2 ) 5 CH 3
615 -CH = CHCH 3 -CH 2 (CH 2 ) 5 CH 3
616 -CH = C (CH 3 ) 2 -CH 2 (CH 2 ) 5 CH 3
617 -C (CH 3 ) = CH 2 -CH 2 (CH 2 ) 5 CH 3
618 -C (CH 3 ) = CHCH 3 -CH 2 (CH 2 ) 5 CH 3
619 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 (CH 2 ) 5 CH 3
620 -CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
621 -CH 2 CH = CH-CH 3 -CH 2 (CH 2 ) 5 CH 3
622 - (CH 2 ) 2 CH = CH 2 -CH 2 (CH 2 ) 5 CH 3
623 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
624 -CH 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
625 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 (CH 2 ) 5 CH 3
626 - (CH 2 ) 3 CH = CH 2 -CH 2 (CH 2 ) 5 CH 3
627 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 5 CH 3
628 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
629 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
630 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 (CH 2 ) 5 CH 3
631 - (CH 2 ) 4 CH = CH 2 -CH 2 (CH 2 ) 5 CH 3
632 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 5 CH 3
633 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 5 CH 3
634 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
635 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
636 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 (CH 2 ) 5 CH 3
637 - (CH 2 ) 5 CH = CH 2 -CH 2 (CH 2 ) 5 CH 3
638 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 5 CH 3
639 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 5 CH 3
640 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 5 CH 3
641 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
642 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 5 CH 3
643 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 (CH 2 ) 5 CH 3
644 - (CH 2 ) 6 CH = CH 2 -CH 2 (CH 2 ) 5 CH 3
645 -CH 3 -CH 2 (CH 2 ) 6 CH 3
646 -CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
647 -CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
648 -CH (CH 3 ) 2 -CH 2 (CH 2 ) 6 CH 3
649 -CH 2 CH 2 CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
650 -CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
651 -CH 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 6 CH 3
652 -C (CH 3 ) 3 -CH 2 (CH 2 ) 6 CH 3
653 -CH 2 (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 6 CH 3
654 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
655 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
656 - (CH 2 ) 2 CH (CH 3 ) 2 -CH 2 (CH 2 ) 6 CH 3
657 -CH 2 (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 6 CH 3
658 -CH 2 (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 6 CH 3
59 -CH 2 (CH 2 ) 6 CH 3 -CH 2 (CH 2 ) 6 CH 3
660 -CH = CH 2 -CH 2 (CH 2 ) 6 CH 3
661 -CH = CHCH 3 -CH 2 (CH 2 ) 6 CH 3
662 -CH = C (CH 3 ) 2 -CH 2 (CH 2 ) 6 CH 3
663 -C (CH 3 ) = CH 2 -CH 2 (CH 2 ) 6 CH 3
664 -C (CH 3 ) = CHCH 3 -CH 2 (CH 2 ) 6 CH 3
665 -C (CH 3 ) = C (CH 3 ) 2 -CH 2 (CH 2 ) 6 CH 3
666 -CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
667 -CH 2 CH = CH-CH 3 -CH 2 (CH 2 ) 6 CH 3
668 - (CH 2 ) 2 CH = CH 2 -CH 2 (CH 2 ) 6 CH 3
669 -CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
670 -CH 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
671 - (CH 2 ) 2 CH = CH-CH 3 -CH 2 (CH 2 ) 6 CH 3
672 - (CH 2 ) 3 CH = CH 2 -CH 2 (CH 2 ) 6 CH 3
673 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 6 CH 3
674 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
675 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
676 - (CH 2 ) 3 CH = CH-CH 3 -CH 2 (CH 2 ) 6 CH 3
677 - (CH 2 ) 4 CH = CH 2 -CH 2 (CH 2 ) 6 CH 3
678 -CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 6 CH 3
679 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 6 CH 3
680 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
681 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
682 - (CH 2 ) 4 CH = CH-CH 3 -CH 2 (CH 2 ) 6 CH 3
683 - (CH 2 ) 5 CH = CH 2 -CH 2 (CH 2 ) 6 CH 3
684 -CH = CH- (CH 2 ) 5 CH 3 -CH 2 (CH 2 ) 6 CH 3
685 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH 2 (CH 2 ) 6 CH 3
686 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH 2 (CH 2 ) 6 CH 3
687 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
688 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH 2 (CH 2 ) 6 CH 3
689 - (CH 2 ) 5 CH = CH-CH 3 -CH 2 (CH 2 ) 6 CH 3
690 - (CH 2 ) 6 CH = CH 2 -CH 2 (CH 2 ) 6 CH 3
691 -CH 3 -CH = CH 2
692 -CH 2 CH 3 -CH = CH 2
693 -CH 2 CH 2 CH 3 -CH = CH 2
694 -CH (CH 3 ) 2 -CH = CH 2
695 -CH 2 CH 2 CH 2 CH 3 -CH = CH 2
696 -CH (CH 3 ) CH 2 CH 3 -CH = CH 2
697 -CH 2 CH (CH 3 ) 2 -CH = CH 2
698 -C (CH 3 ) 3 -CH = CH 2
699 -CH 2 (CH 2 ) 3 CH 3 -CH = CH 2
700 -CH (CH 3 ) (CH 2 ) 2 CH 3 -CH = CH 2
701 -CH 2 CH (CH 3 ) CH 2 CH 3 -CH = CH 2
702 - (CH 2 ) 2 CH (CH 3 ) 2 -CH = CH 2
703 -CH 2 (CH 2 ) 4 CH 3 -CH = CH 2
704 -CH 2 (CH 2 ) 5 CH 3 -CH = CH 2
705 -CH 2 (CH 2 ) 6 CH 3 -CH = CH 2
706 -CH = CH 2 -CH = CH 2
707 -CH = CHCH 3 -CH = CH 2
708 -CH = C (CH 3 ) 2 -CH = CH 2
709 -C (CH 3 ) = CH 2 -CH = CH 2
710 -C (CH 3 ) = CHCH 3 -CH = CH 2
711 -C (CH 3 ) = C (CH 3 ) 2 -CH = CH 2
712 -CH = CH-CH 2 CH 3 -CH = CH 2
713 -CH 2 CH = CH-CH 3 -CH = CH 2
714 - (CH 2 ) 2 CH = CH 2 -CH = CH 2
715 -CH = CH- (CH 2 ) 2 CH 3 -CH = CH 2
716 -CH 2 CH = CH-CH 2 CH 3 -CH = CH 2
717 - (CH 2 ) 2 CH = CH-CH 3 -CH = CH 2
718 - (CH 2 ) 3 CH = CH 2 -CH = CH 2
719 -CH = CH- (CH 2 ) 3 CH 3 -CH = CH 2
720 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -CH = CH 2
721 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -CH = CH 2
722 - (CH 2 ) 3 CH = CH-CH 3 -CH = CH 2
723 - (CH 2 ) 4 CH = CH 2 -CH = CH 2
724 -CH = CH- (CH 2 ) 3 CH 3 -CH = CH 2
725 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -CH = CH 2
726 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -CH = CH 2
727 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -CH = CH 2
728 - (CH 2 ) 4 CH = CH-CH 3 -CH = CH 2
729 - (CH 2 ) 5 CH = CH 2 -CH = CH 2
730 -CH = CH- (CH 2 ) 5 CH 3 -CH = CH 2
731 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -CH = CH 2
732 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -CH = CH 2
733 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -CH = CH 2
734 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -CH = CH 2
735 - (CH 2 ) 5 CH = CH-CH 3 -CH = CH 2
736 - (CH 2 ) 6 CH = CH 2 -CH = CH 2
737 -CH 3 -C (CH 3 ) = CH 2
738 -CH 2 CH 3 -C (CH 3 ) = CH 2
739 -CH 2 CH 2 CH 3 -C (CH 3 ) = CH 2
740 -CH (CH 3 ) 2 -C (CH 3 ) = CH 2
741 -CH 2 CH 2 CH 2 CH 3 -C (CH 3 ) = CH 2
742 -CH (CH 3 ) CH 2 CH 3 -C (CH 3 ) = CH 2
743 -CH 2 CH (CH 3 ) 2 -C (CH 3 ) = CH 2
744 -C (CH 3 ) 3 -C (CH 3 ) = CH 2
745 -CH 2 (CH 2 ) 3 CH 3 -C (CH 3 ) = CH 2
746 -CH (CH 3 ) (CH 2 ) 2 CH 3 -C (CH 3 ) = CH 2
747 -CH 2 CH (CH 3 ) CH 2 CH 3 -C (CH 3 ) = CH 2
748 - (CH 2 ) 2 CH (CH 3 ) 2 -C (CH 3 ) = CH 2
749 -CH 2 (CH 2 ) 4 CH 3 -C (CH 3 ) = CH 2
750 -CH 2 (CH 2 ) 5 CH 3 -C (CH 3 ) = CH 2
751 -CH 2 (CH 2 ) 6 CH 3 -C (CH 3 ) = CH 2
752 -CH = CH 2 -C (CH 3 ) = CH 2
753 -CH = CHCH 3 -C (CH 3 ) = CH 2
754 -CH = C (CH 3 ) 2 -C (CH 3 ) = CH 2
755 -C (CH 3 ) = CH 2 -C (CH 3 ) = CH 2
756 -C (CH 3 ) = CHCH 3 -C (CH 3 ) = CH 2
757 -C (CH 3 ) = C (CH 3 ) 2 -C (CH 3 ) = CH 2
758 -CH = CH-CH 2 CH 3 -C (CH 3 ) = CH 2
759 -CH 2 CH = CH-CH 3 -C (CH 3 ) = CH 2
760 - (CH 2 ) 2 CH = CH 2 -C (CH 3 ) = CH 2
761 -CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) = CH 2
762 -CH 2 CH = CH-CH 2 CH 3 -C (CH 3 ) = CH 2
763 - (CH 2 ) 2 CH = CH-CH 3 -C (CH 3 ) = CH 2
764 - (CH 2 ) 3 CH = CH 2 -C (CH 3 ) = CH 2
765 -CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) = CH 2
766 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) = CH 2
767 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -C (CH 3 ) = CH 2
768 - (CH 2 ) 3 CH = CH-CH 3 -C (CH 3 ) = CH 2
769 - (CH 2 ) 4 CH = CH 2 -C (CH 3 ) = CH 2
770 -CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) = CH 2
771 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) = CH 2
772 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) = CH 2
773 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -C (CH 3 ) = CH 2
774 - (CH 2 ) 4 CH = CH-CH 3 -C (CH 3 ) = CH 2
775 - (CH 2 ) 5 CH = CH 2 -C (CH 3 ) = CH 2
776 -CH = CH- (CH 2 ) 5 CH 3 -C (CH 3 ) = CH 2
777 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -C (CH 3 ) = CH 2
778 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -C (CH 3 ) = CH 2
779 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -C (CH 3 ) = CH 2
780 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -C (CH 3 ) = CH 2
781 - (CH 2 ) 5 CH = CH-CH 3 -C (CH 3 ) = CH 2
782 - (CH 2 ) 6 CH = CH 2 -C (CH 3 ) = CH 2
783 -CH 3 -O-CH 3
784 -CH 2 CH 3 -O-CH 3
785 -CH 2 CH 2 CH 3 -O-CH 3
786 -CH (CH 3 ) 2 -O-CH 3
787 -CH 2 CH 2 CH 2 CH 3 -O-CH 3
788 -CH (CH 3 ) CH 2 CH 3 -O-CH 3
789 -CH 2 CH (CH 3 ) 2 -O-CH 3
790 -C (CH 3 ) 3 -O-CH 3
791 -CH 2 (CH 2 ) 3 CH 3 -O-CH 3
792 -CH (CH 3 ) (CH 2 ) 2 CH 3 -O-CH 3
793 -CH 2 CH (CH 3 ) CH 2 CH 3 -O-CH 3
794 - (CH 2 ) 2 CH (CH 3 ) 2 -O-CH 3
795 -CH 2 (CH 2 ) 4 CH 3 -O-CH 3
796 -CH 2 (CH 2 ) 5 CH 3 -O-CH 3
797 -CH 2 (CH 2 ) 6 CH 3 -O-CH 3
798 -CH = CH 2 -O-CH 3
799 -CH = CHCH 3 -O-CH 3
800 -CH = C (CH 3 ) 2 -O-CH 3
801 -C (CH 3 ) = CH 2 -O-CH 3
802 -C (CH 3 ) = CHCH 3 -O-CH 3
803 -C (CH 3 ) = C (CH 3 ) 2 -O-CH 3
804 -CH = CH-CH 2 CH 3 -O-CH 3
805 -CH 2 CH = CH-CH 3 -O-CH 3
806 - (CH 2 ) 2 CH = CH 2 -O-CH 3
807 -CH = CH- (CH 2 ) 2 CH 3 -O-CH 3
808 -CH 2 CH = CH-CH 2 CH 3 -O-CH 3
809 - (CH 2 ) 2 CH = CH-CH 3 -O-CH 3
810 - (CH 2 ) 3 CH = CH 2 -O-CH 3
811 -CH = CH- (CH 2 ) 3 CH 3 -O-CH 3
812 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH 3
813 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -O-CH 3
814 - (CH 2 ) 3 CH = CH-CH 3 -O-CH 3
815 - (CH 2 ) 4 CH = CH 2 -O-CH 3
816 -CH = CH- (CH 2 ) 3 CH 3 -O-CH 3
817 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH 3
818 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH 3
819 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -O-CH 3
820 - (CH 2 ) 4 CH = CH-CH 3 -O-CH 3
821 - (CH 2 ) 5 CH = CH 2 -O-CH 3
822 -CH = CH- (CH 2 ) 5 CH 3 -O-CH 3
823 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -O-CH 3
824 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH 3
825 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -O-CH 3
826 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -O-CH 3
827 - (CH 2 ) 5 CH = CH-CH 3 -O-CH 3
828 - (CH 2 ) 6 CH = CH 2 -O-CH 3
829 -CH 3 -O-CH 2 CH 3
830 -CH 2 CH 3 -O-CH 2 CH 3
831 -CH 2 CH 2 CH 3 -O-CH 2 CH 3
832 -CH (CH 3 ) 2 -O-CH 2 CH 3
833 -CH 2 CH 2 CH 2 CH 3 -O-CH 2 CH 3
834 -CH (CH 3 ) CH 2 CH 3 -O-CH 2 CH 3
835 -CH 2 CH (CH 3 ) 2 -O-CH 2 CH 3
836 -C (CH 3 ) 3 -O-CH 2 CH 3
837 -CH 2 (CH 2 ) 3 CH 3 -O-CH 2 CH 3
838 -CH (CH 3 ) (CH 2 ) 2 CH 3 -O-CH 2 CH 3
839 -CH 2 CH (CH 3 ) CH 2 CH 3 -O-CH 2 CH 3
840 - (CH 2 ) 2 CH (CH 3 ) 2 -O-CH 2 CH 3
841 -CH 2 (CH 2 ) 4 CH 3 -O-CH 2 CH 3
842 -CH 2 (CH 2 ) 5 CH 3 -O-CH 2 CH 3
843 -CH 2 (CH 2 ) 6 CH 3 -O-CH 2 CH 3
844 -CH = CH 2 -O-CH 2 CH 3
845 -CH = CHCH 3 -O-CH 2 CH 3
846 -CH = C (CH 3 ) 2 -O-CH 2 CH 3
847 -C (CH 3 ) = CH 2 -O-CH 2 CH 3
848 -C (CH 3 ) = CHCH 3 -O-CH 2 CH 3
849 -C (CH 3 ) = C (CH 3 ) 2 -O-CH 2 CH 3
850 -CH = CH-CH 2 CH 3 -O-CH 2 CH 3
851 -CH 2 CH = CH-CH 3 -O-CH 2 CH 3
852 - (CH 2 ) 2 CH = CH 2 -O-CH 2 CH 3
853 -CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 3
854 -CH 2 CH = CH-CH 2 CH 3 -O-CH 2 CH 3
855 - (CH 2 ) 2 CH = CH-CH 3 -O-CH 2 CH 3
856 - (CH 2 ) 3 CH = CH 2 -O-CH 2 CH 3
857 -CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 3
858 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 3
859 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -O-CH 2 CH 3
860 - (CH 2 ) 3 CH = CH-CH 3 -O-CH 2 CH 3
861 - (CH 2 ) 4 CH = CH 2 -O-CH 2 CH 3
862 -CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 3
863 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 3
864 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 3
865 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -O-CH 2 CH 3
866 - (CH 2 ) 4 CH = CH-CH 3 -O-CH 2 CH 3
867 - (CH 2 ) 5 CH = CH 2 -O-CH 2 CH 3
868 -CH = CH- (CH 2 ) 5 CH 3 -O-CH 2 CH 3
869 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -O-CH 2 CH 3
870 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 3
871 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 3
872 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -O-CH 2 CH 3
873 - (CH 2 ) 5 CH = CH-CH 3 -O-CH 2 CH 3
874 - (CH 2 ) 6 CH = CH 2 -O-CH 2 CH 3
875 -CH 3 -O-CH 2 CH 2 CH 3
876 -CH 2 CH 3 -O-CH 2 CH 2 CH 3
877 -CH 2 CH 2 CH 3 -O-CH 2 CH 2 CH 3
878 -CH (CH 3 ) 2 -O-CH 2 CH 2 CH 3
879 -CH 2 CH 2 CH 2 CH 3 -O-CH 2 CH 2 CH 3
880 -CH (CH 3 ) CH 2 CH 3 -O-CH 2 CH 2 CH 3
881 -CH 2 CH (CH 3 ) 2 -O-CH 2 CH 2 CH 3
882 -C (CH 3 ) 3 -O-CH 2 CH 2 CH 3
883 -CH 2 (CH 2 ) 3 CH 3 -O-CH 2 CH 2 CH 3
884 -CH (CH 3 ) (CH 2 ) 2 CH 3 -O-CH 2 CH 2 CH 3
885 -CH 2 CH (CH 3 ) CH 2 CH 3 -O-CH 2 CH 2 CH 3
886 - (CH 2 ) 2 CH (CH 3 ) 2 -O-CH 2 CH 2 CH 3
887 -CH 2 (CH 2 ) 4 CH 3 -O-CH 2 CH 2 CH 3
888 -CH 2 (CH 2 ) 5 CH 3 -O-CH 2 CH 2 CH 3
889 -CH 2 (CH 2 ) 6 CH 3 -O-CH 2 CH 2 CH 3
890 -CH = CH 2 -O-CH 2 CH 2 CH 3
891 -CH = CHCH 3 -O-CH 2 CH 2 CH 3
892 -CH = C (CH 3 ) 2 -O-CH 2 CH 2 CH 3
893 -C (CH 3 ) = CH 2 -O-CH 2 CH 2 CH 3
894 -C (CH 3 ) = CHCH 3 -O-CH 2 CH 2 CH 3
895 -C (CH 3 ) = C (CH 3 ) 2 -O-CH 2 CH 2 CH 3
896 -CH = CH-CH 2 CH 3 -O-CH 2 CH 2 CH 3
897 -CH 2 CH = CH-CH 3 -O-CH 2 CH 2 CH 3
898 - (CH 2 ) 2 CH = CH 2 -O-CH 2 CH 2 CH 3
899 -CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 2 CH 3
900 -CH 2 CH = CH-CH 2 CH 3 -O-CH 2 CH 2 CH 3
901 - (CH 2 ) 2 CH = CH-CH 3 -O-CH 2 CH 2 CH 3
902 - (CH 2 ) 3 CH = CH 2 -O-CH 2 CH 2 CH 3
903 -CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 2 CH 3
904 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 2 CH 3
905 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -O-CH 2 CH 2 CH 3
906 - (CH 2 ) 3 CH = CH-CH 3 -O-CH 2 CH 2 CH 3
907 - (CH 2 ) 4 CH = CH 2 -O-CH 2 CH 2 CH 3
908 -CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 2 CH 3
909 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 2 CH 3
910 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 2 CH 3
911 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -O-CH 2 CH 2 CH 3
912 - (CH 2 ) 4 CH = CH-CH 3 -O-CH 2 CH 2 CH 3
913 - (CH 2 ) 5 CH = CH 2 -O-CH 2 CH 2 CH 3
914 -CH = CH- (CH 2 ) 5 CH 3 -O-CH 2 CH 2 CH 3
915 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -O-CH 2 CH 2 CH 3
916 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH 2 CH 2 CH 3
917 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -O-CH 2 CH 2 CH 3
918 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -O-CH 2 CH 2 CH 3
919 - (CH 2 ) 5 CH = CH-CH 3 -O-CH 2 CH 2 CH 3
920 - (CH 2 ) 6 CH = CH 2 -O-CH 2 CH 2 CH 3
921 -CH 3 -O-CH (CH 3 ) 2
922 -CH 2 CH 3 -O-CH (CH 3 ) 2
923 -CH 2 CH 2 CH 3 -O-CH (CH 3 ) 2
924 -CH (CH 3 ) 2 -O-CH (CH 3 ) 2
925 -CH 2 CH 2 CH 2 CH 3 -O-CH (CH 3 ) 2
926 -CH (CH 3 ) CH 2 CH 3 -O-CH (CH 3 ) 2
927 -CH 2 CH (CH 3 ) 2 -O-CH (CH 3 ) 2
928 -C (CH 3 ) 3 -O-CH (CH 3 ) 2
929 -CH 2 (CH 2 ) 3 CH 3 -O-CH (CH 3 ) 2
930 -CH (CH 3 ) (CH 2 ) 2 CH 3 -O-CH (CH 3 ) 2
931 -CH 2 CH (CH 3 ) CH 2 CH 3 -O-CH (CH 3 ) 2
932 - (CH 2 ) 2 CH (CH 3 ) 2 -O-CH (CH 3 ) 2
933 -CH 2 (CH 2 ) 4 CH 3 -O-CH (CH 3 ) 2
934 -CH 2 (CH 2 ) 5 CH 3 -O-CH (CH 3 ) 2
935 -CH 2 (CH 2 ) 6 CH 3 -O-CH (CH 3 ) 2
936 -CH = CH 2 -O-CH (CH 3 ) 2
937 -CH = CHCH 3 -O-CH (CH 3 ) 2
938 -CH = C (CH 3 ) 2 -O-CH (CH 3 ) 2
939 -C (CH 3 ) = CH 2 -O-CH (CH 3 ) 2
940 -C (CH 3 ) = CHCH 3 -O-CH (CH 3 ) 2
941 -C (CH 3 ) = C (CH 3 ) 2 -O-CH (CH 3 ) 2
942 -CH = CH-CH 2 CH 3 -O-CH (CH 3 ) 2
943 -CH 2 CH = CH-CH 3 -O-CH (CH 3 ) 2
944 - (CH 2 ) 2 CH = CH 2 -O-CH (CH 3 ) 2
945 -CH = CH- (CH 2 ) 2 CH 3 -O-CH (CH 3 ) 2
946 -CH 2 CH = CH-CH 2 CH 3 -O-CH (CH 3 ) 2
947 - (CH 2 ) 2 CH = CH-CH 3 -O-CH (CH 3 ) 2
948 - (CH 2 ) 3 CH = CH 2 -O-CH (CH 3 ) 2
949 -CH = CH- (CH 2 ) 3 CH 3 -O-CH (CH 3 ) 2
950 -CH 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH (CH 3 ) 2
951 - (CH 2 ) 2 CH = CH-CH 2 CH 3 -O-CH (CH 3 ) 2
952 - (CH 2 ) 3 CH = CH-CH 3 -O-CH (CH 3 ) 2
953 - (CH 2 ) 4 CH = CH 2 -O-CH (CH 3 ) 2
954 -CH = CH- (CH 2 ) 3 CH 3 -O-CH (CH 3 ) 2
955 -CH 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH (CH 3 ) 2
956 - (CH 2 ) 2 CH = CH- (CH 2 ) 2 CH 3 -O-CH (CH 3 ) 2
957 - (CH 2 ) 3 CH = CH-CH 2 CH 3 -O-CH (CH 3 ) 2
958 - (CH 2 ) 4 CH = CH-CH 3 -O-CH (CH 3 ) 2
959 - (CH 2 ) 5 CH = CH 2 -O-CH (CH 3 ) 2
960 -CH = CH- (CH 2 ) 5 CH 3 -O-CH (CH 3 ) 2
961 -CH 2 CH = CH- (CH 2 ) 4 CH 3 -O-CH (CH 3 ) 2
962 - (CH 2 ) 2 CH = CH- (CH 2 ) 3 CH 3 -O-CH (CH 3 ) 2
963 - (CH 2 ) 3 CH = CH- (CH 2 ) 2 CH 3 -O-CH (CH 3 ) 2
964 - (CH 2 ) 4 CH = CH-CH 2 CH 3 -O-CH (CH 3 ) 2
965 - (CH 2 ) 5 CH = CH-CH 3 -O-CH (CH 3 ) 2
966 - (CH 2 ) 6 CH = CH 2 -O-CH (CH 3 ) 2
Als weiterhin besonders geeignet haben sich im Rahmen der vorliegenden Erfindung Carvonacetale der Formel
erwiesen, in der R7 bis R12 unabhängig voneinander ausgewählt sind aus -H, -CH3, -CH2CH3, -CH2CH2CH3, -CH(CH3)2, -CH2 CH2CH2CH3, -CH2CH(CH3)2, -CH(CH3)CH2CH3, -C(CH3)3 oder R9 und R10 zusammen eine chemische Bindung oder eine Gruppe -(CR13R14)x bedeuten, worin x für die Werte 1 oder 2 steht und R13 und R14 unabhängig voneinander ausgewählt sind aus -H, - CH3, -CH2CH3, -CH2CH2CH3, -CH(CH3)2, -CH2 CH2CH2CH3, -CH2CH(CH3)2, -CH(CH3)CH2CH3, - C(CH3)3 Further particularly suitable within the scope of the present invention are carvone acetals of the formula in which R 7 to R 12 are independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH (CH 3 ) 2 , -CH 2 CH 2 CH 2 CH 3 , -CH 2 CH (CH 3 ) 2 , -CH (CH 3 ) CH 2 CH 3 , -C (CH 3 ) 3 or R 9 and R 10 together represent a chemical bond or a group - (CR 13 R 14) x , where x is the values 1 or 2 and R 13 and R 14 are independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH (CH 3 ) 2 , -CH 2 CH 2 CH 2 CH 3 , -CH 2 CH (CH 3 ) 2 , -CH (CH 3 ) CH 2 CH 3 , -C (CH 3 ) 3
Einzelne Spezies, die der vorstehend genannten Formel genügen, sind hinsichtlich ihrer Reste R7 bis R12 in der nachstehenden Tabelle 3 aufgeführt. Diese sind erfindungsgemäß besonders bevorzugt.
Tabelle 3: Bevorzugte Carvonacetale Nr. R7 R8 R9 R10 R11 R12
1 -H -H -H -H -H -H
2 -CH3 -H -H -H -H -H
3 -CH2CH3 -H -H -H -H -H
4 -CH2CH2CH3 -H -H -H -H -H
5 -CH(CH3)2 -H -H -H -H -H
6 -CH2CH2CH2CH3 -H -H -H -H -H
7 -CH(CH3)CH2CH3 -H -H -H -H -H
8 -CH2CH(CH3)2 -H -H -H -H -H
9 -C(CH3)3 -H -H -H -H -H
10 -H -CH3 -H -H -H -H
11 -CH3 -CH3 -H -H -H -H
12 -CH2CH3 -CH3 -H -H -H -H
13 -CH2CH2CH3 -CH3 -H -H -H -H
14 -CH(CH3)2 -CH3 -H -H -H -H
15 -CH2CH2CH2CH3 -CH3 -H -H -H -H
16 -CH(CH3)CH2CH3 -CH3 -H -H -H -H
17 -CH2CH(CH3)2 -CH3 -H -H -H -H
18 -C(CH3)3 -CH3 -H -H -H -H
19 -H -CH3 -CH3 -H -H -H
20 -CH3 -CH3 -CH3 -H -H -H
21 -CH2CH3 -CH3 -CH3 -H -H -H
22 -CH2CH2CH3 -CH3 -CH3 -H -H -H
23 -CH(CH3)2 -CH3 -CH3 -H -H -H
24 -CH2CH2CH2CH3 -CH3 -CH3 -H -H -H
25 -CH(CH3)CH2CH3 -CH3 -CH3 -H -H -H
26 -CH2CH(CH3)2 -CH3 -CH3 -H -H -H
27 -C(CH3)3 -CH3 -CH3 -H -H -H
28 -H -CH2CH3 -H -H -H -H
29 -CH3 -CH2CH3 -H -H -H -H
30 -CH2CH3 -CH2CH3 -H -H -H -H
31 -CH2CH2CH3 -CH2CH3 -H -H -H -H
32 -CH(CH3)2 -CH2CH3 -H -H -H -H
33 -CH2CH2CH2CH3 -CH2CH3 -H -H -H -H
34 -CH(CH3)CH2CH3 -CH2CH3 -H -H -H -H
35 -CH2CH(CH3)2 -CH2CH3 -H -H -H -H
36 -C(CH3)3 -CH2CH3 -H -H -H -H
37 -H -CH2CH3 -CH3 -H -H -H
38 -CH3 -CH2CH3 -CH3 -H -H -H
39 -CH2CH3 -CH2CH3 -CH3 -H -H -H
40 -CH2CH2CH3 -CH2CH3 -CH3 -H -H -H
41 -CH(CH3)2 -CH2CH3 -CH3 -H -H -H
42 -CH2CH2CH2CH3 -CH2CH3 -CH3 -H -H -H
43 -CH(CH3)CH2CH3 -CH2CH3 -CH3 -H -H -H
44 -CH2CH(CH3)2 -CH2CH3 -CH3 -H -H -H
45 -C(CH3)3 -CH2CH3 -CH3 -H -H -H
46 -H -CH2CH3 -CH2CH3 -H -H -H
47 -CH3 -CH2CH3 -CH2CH3 -H -H -H
48 -CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
49 -CH2CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
50 -CH(CH3)2 -CH2CH3 -CH2CH3 -H -H -H
51 -CH2CH2CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
52 -CH(CH3)CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
53 -CH2CH(CH3)2 -CH2CH3 -CH2CH3 -H -H -H
54 -C(CH3)3 -CH2CH3 -CH2CH3 -H -H -H
55 -H -CH2CH2CH3 -H -H -H -H
56 -CH3 -CH2CH2CH3 -H -H -H -H
57 -CH2CH3 -CH2CH2CH3 -H -H -H -H
58 -CH2CH2CH3 -CH2CH2CH3 -H -H -H -H
59 -CH(CH3)2 -CH2CH2CH3 -H -H -H -H
60 -CH2CH2CH2CH3 -CH2CH2CH3 -H -H -H -H
61 -CH(CH3)CH2CH3 -CH2CH2CH3 -H -H -H -H
62 -CH2CH(CH3)2 -CH2CH2CH3 -H -H -H -H
63 -C(CH3)3 -CH2CH2CH3 -H -H -H -H
64 -H -CH2CH2CH3 -CH3 -H -H -H
65 -CH3 -CH2CH2CH3 -CH3 -H -H -H
66 -CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
67 -CH2CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
68 -CH(CH3)2 -CH2CH2CH3 -CH3 -H -H -H
69 -CH2CH2CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
70 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
71 -CH2CH(CH3)2 -CH2CH2CH3 -CH3 -H -H -H
72 -C(CH3)3 -CH2CH2CH3 -CH3 -H -H -H
73 -H -CH2CH2CH3 -CH2CH3 -H -H -H
74 -CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
75 -CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
76 -CH2CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
77 -CH(CH3)2 -CH2CH2CH3 -CH2CH3 -H -H -H
78 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
79 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
80 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH3 -H -H -H
81 -C(CH3)3 -CH2CH2CH3 -CH2CH3 -H -H -H
82 -H -CH2CH2CH3 -CH2CH2CH3 -H -H -H
83 -CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
84 -CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
85 -CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
86 -CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
87 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
88 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
89 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
90 -C(CH3)3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
91 -H -CH(CH3)2 -H -H -H -H
92 -CH3 -CH(CH3)2 -H -H -H -H
93 -CH2CH3 -CH(CH3)2 -H -H -H -H
94 -CH2CH2CH3 -CH(CH3)2 -H -H -H -H
95 -CH(CH3)2 -CH(CH3)2 -H -H -H -H
96 -CH2CH2CH2CH3 -CH(CH3)2 -H -H -H -H
97 -CH(CH3)CH2CH3 -CH(CH3)2 -H -H -H -H
98 -CH2CH(CH3)2 -CH(CH3)2 -H -H -H -H
99 -C(CH3)3 -CH(CH3)2 -H -H -H -H
100 -H -CH(CH3)2 -CH3 -H -H -H
101 -CH3 -CH(CH3)2 -CH3 -H -H -H
102 -CH2CH3 -CH(CH3)2 -CH3 -H -H -H
103 -CH2CH2CH3 -CH(CH3)2 -CH3 -H -H -H
104 -CH(CH3)2 -CH(CH3)2 -CH3 -H -H -H
105 -CH2CH2CH2CH3 -CH(CH3)2 -CH3 -H -H -H
106 -CH(CH3)CH2CH3 -CH(CH3)2 -CH3 -H -H -H
107 -CH2CH(CH3)2 -CH(CH3)2 -CH3 -H -H -H
108 -C(CH3)3 -CH(CH3)2 -CH3 -H -H -H
109 -H -CH(CH3)2 -CH2CH3 -H -H -H
110 -CH3 -CH(CH3)2 -CH2CH3 -H -H -H
111 -CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
112 -CH2CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
113 -CH(CH3)2 -CH(CH3)2 -CH2CH3 -H -H -H
114 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
115 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
116 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH3 -H -H -H
117 -C(CH3)3 -CH(CH3)2 -CH2CH3 -H -H -H
118 -H -CH(CH3)2 -CH2CH2CH3 -H -H -H
119 -CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
120 -CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
121 -CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
122 -CH(CH3)2 -CH(CH3)2 -CH2CH2CH3 -H -H -H
123 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
124 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
125 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH2CH3 -H -H -H
126 -C(CH3)3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
127 -H -CH(CH3)2 -CH(CH3)2 -H -H -H
128 -CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
129 -CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
130 -CH2CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
131 -CH(CH3)2 -CH(CH3)2 -CH(CH3)2 -H -H -H
132 -CH2CH2CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
133 -CH(CH3)CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
134 -CH2CH(CH3)2 -CH(CH3)2 -CH(CH3)2 -H -H -H
135 -C(CH3)3 -CH(CH3)2 -CH(CH3)2 -H -H -H
Nr. R10 R11 R12 R7 R8 R9
136 -H -H -H -H -H -H
137 -CH3 -H -H -H -H -H
138 -CH2CH3 -H -H -H -H -H
139 -CH2CH2CH3 -H -H -H -H -H
140 -CH(CH3)2 -H -H -H -H -H
141 -CH2CH2CH2CH3 -H -H -H -H -H
142 -CH(CH3)CH2CH3 -H -H -H -H -H
143 -CH2CH(CH3)2 -H -H -H -H -H
144 -C(CH3)3 -H -H -H -H -H
145 -H -CH3 -H -H -H -H
146 -CH3 -CH3 -H -H -H -H
147 -CH2CH3 -CH3 -H -H -H -H
148 -CH2CH2CH3 -CH3 -H -H -H -H
149 -CH(CH3)2 -CH3 -H -H -H -H
150 -CH2CH2CH2CH3 -CH3 -H -H -H -H
151 -CH(CH3)CH2CH3 -CH3 -H -H -H -H
152 -CH2CH(CH3)2 -CH3 -H -H -H -H
153 -C(CH3)3 -CH3 -H -H -H -H
154 -H -CH3 -CH3 -H -H -H
155 -CH3 -CH3 -CH3 -H -H -H
156 -CH2CH3 -CH3 -CH3 -H -H -H
157 -CH2CH2CH3 -CH3 -CH3 -H -H -H
158 -CH(CH3)2 -CH3 -CH3 -H -H -H
159 -CH2CH2CH2CH3 -CH3 -CH3 -H -H -H
160 -CH(CH3)CH2CH3 -CH3 -CH3 -H -H -H
161 -CH2CH(CH3)2 -CH3 -CH3 -H -H -H
162 -C(CH3)3 -CH3 -CH3 -H -H -H
163 -H -CH2CH3 -H -H -H -H
164 -CH3 -CH2CH3 -H -H -H -H
165 -CH2CH3 -CH2CH3 -H -H -H -H
166 -CH2CH2CH3 -CH2CH3 -H -H -H -H
167 -CH(CH3)2 -CH2CH3 -H -H -H -H
168 -CH2CH2CH2CH3 -CH2CH3 -H -H -H -H
169 -CH(CH3)CH2CH3 -CH2CH3 -H -H -H -H
170 -CHzCH(CH3)2 -CH2CH3 -H -H -H -H
171 -C(CH3)3 -CH2CH3 -H -H -H -H
172 -H -CH2CH3 -CH3 -H -H -H
173 -CH3 -CH2CH3 -CH3 -H -H -H
174 -CH2CH3 -CH2CH3 -CH3 -H -H -H
175 -CH2CH2CH3 -CH2CH3 -CH3 -H -H -H
176 -CH(CH3)2 -CH2CH3 -CH3 -H -H -H
177 -CH2CH2CH2CH3 -CH2CH3 -CH3 -H -H -H
178 -CH(CH3)CH2CH3 -CH2CH3 -CH3 -H -H -H
179 -CH2CH(CH3)2 -CH2CH3 -CH3 -H -H -H
180 -C(CH3)3 -CH2CH3 -CH3 -H -H -H
181 -H -CH2CH3 -CH2CH3 -H -H -H
182 -CH3 -CH2CH3 -CH2CH3 -H -H -H
183 -CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
184 -CH2CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
185 -CH(CH3)2 -CH2CH3 -CH2CH3 -H -H -H
186 -CH2CH2CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
187 -CH(CH3)CH2CH3 -CH2CH3 -CH2CH3 -H -H -H
188 -CH2CH(CH3)2 -CH2CH3 -CH2CH3 -H -H -H
189 -C(CH3)3 -CH2CH3 -CH2CH3 -H -H -H
190 -H -CH2CH2CH3 -H -H -H -H
191 -CH3 -CH2CH2CH3 -H -H -H -H
192 -CH2CH3 -CH2CH2CH3 -H -H -H -H
193 -CH2CH2CH3 -CH2CH2CH3 -H -H -H -H
194 -CH(CH3)2 -CH2CH2CH3 -H -H -H -H
195 -CH2CH2CH2CH3 -CH2CH2CH3 -H -H -H -H
196 -CH(CH3)CH2CH3 -CH2CH2CH3 -H -H -H -H
197 -CH2CH(CH3)2 -CH2CH2CH3 -H -H -H -H
198 -C(CH3)3 -CH2CH2CH3 -H -H -H -H
199 -H -CH2CH2CH3 -CH3 -H -H -H
200 -CH3 -CH2CH2CH3 -CH3 -H -H -H
201 -CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
202 -CH2CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
203 -CH(CH3)2 -CH2CH2CH3 -CH3 -H -H -H
204 -CH2CH2CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
205 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH3 -H -H -H
206 -CH2CH(CH3)2 -CH2CH2CH3 -CH3 -H -H -H
207 -C(CH3)3 -CH2CH2CH3 -CH3 -H -H -H
208 -H -CH2CH2CH3 -CH2CH3 -H -H -H
209 -CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
210 -CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
211 -CH2CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
212 -CH(CH3)2 -CH2CH2CH3 -CH2CH3 -H -H -H
213 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
214 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH3 -H -H -H
215 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH3 -H -H -H
216 -C(CH3)3 -CH2CH2CH3 -CH2CH3 -H -H -H
217 -H -CH2CH2CH3 -CH2CH2CH3 -H -H -H
218 -CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
219 -CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
220 -CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
221 -CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
222 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
223 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
224 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
225 -C(CH3)3 -CH2CH2CH3 -CH2CH2CH3 -H -H -H
226 -H -CH(CH3)2 -H -H -H -H
227 -CH3 -CH(CH3)2 -H -H -H -H
228 -CH2CH3 -CH(CH3)2 -H -H -H -H
229 -CH2CH2CH3 -CH(CH3)2 -H -H -H -H
230 -CH(CH3)2 -CH(CH3)2 -H -H -H -H
231 -CH2CH2CH2CH3 -CH(CH3)2 -H -H -H -H
232 -CH(CH3)CH2CH3 -CH(CH3)2 -H -H -H -H
233 -CH2CH(CH3)2 -CH(CH3)2 -H -H -H -H
234 -C(CH3)3 -CH(CH3)2 -H -H -H -H
235 -H -CH(CH3)2 -CH3 -H -H -H
236 -CH3 -CH(CH3)2 -CH3 -H -H -H
237 -CH2CH3 -CH(CH3)2 -CH3 -H -H -H
238 -CH2CH2CH3 -CH(CH3)2 -CH3 -H -H -H
239 -CH(CH3)2 -CH(CH3)2 -CH3 -H -H -H
240 -CH2CH2CH2CH3 -CH(CH3)2 -CH3 -H -H -H
241 -CH(CH3)CH2CH3 -CH(CH3)2 -CH3 -H -H -H
242 -CH2CH(CH3)2 -CH(CH3)2 -CH3 -H -H -H
243 -C(CH3)3 -CH(CH3)2 -CH3 -H -H -H
244 -H -CH(CH3)2 -CH2CH3 -H -H -H
245 -CH3 -CH(CH3)2 -CH2CH3 -H -H -H
246 -CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
247 -CH2CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
248 -CH(CH3)2 -CH(CH3)2 -CH2CH3 -H -H -H
249 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
250 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH3 -H -H -H
251 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH3 -H -H -H
252 -C(CH3)3 -CH(CH3)2 -CH2CH3 -H -H -H
253 -H -CH(CH3)2 -CH2CH2CH3 -H -H -H
254 -CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
255 -CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
256 -CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
257 -CH(CH3)2 -CH(CH3)2 -CH2CH2CH3 -H -H -H
258 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
259 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
260 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH2CH3 -H -H -H
261 -C(CH3)3 -CH(CH3)2 -CH2CH2CH3 -H -H -H
262 -H -CH(CH3)2 -CH(CH3)2 -H -H -H
263 -CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
264 -CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
265 -CH2CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
266 -CH(CH3)2 -CH(CH3)2 -CH(CH3)2 -H -H -H
267 -CH2CH2CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
268 -CH(CH3)CH2CH3 -CH(CH3)2 -CH(CH3)2 -H -H -H
269 -CH2CH(CH3)2 -CH(CH3)2 - CH(CH3)2 -H -H -H
270 -C(CH3)3 -CH(CH3)2 - CH(CH3)2 -H -H -H
Nr. R7 R8 R9 R10 R11 R12
271 -H -H -H -H -H -H
272 -CH3 -H -H -CH3 -H -H
273 -CH2CH3 -H -H -CH2CH3 -H -H
274 -CH2CH2CH3 -H -H -CH2CH2CH3 -H -H
275 -CH(CH3)2 -H -H -CH(CH3)2 -H -H
276 -CH2CH2CH2CH3 -H -H -CH2CH2CH2CH3 -H -H
277 -H(CH3)CH2CH3 -H -H -CH(CH3)CH2CH3 -H -H
278 -CH2CH(CH3)2 -H -H -CH2CH(CH3)2 -H -H
279 -C(CH3)3 -H -H -C(CH3)3 -H -H
280 -H -CH3 -H -H -CH3 -H
281 -CH3 -CH3 -H -CH3 -CH3 -H
282 -CH2CH3 -CH3 -H -CH2CH3 -CH3 -H
283 -CH2CH2CH3 -CH3 -H -CH2CH2CH3 -CH3 -H
284 -CH(CH3)2 -CH3 -H -CH(CH3)2 -CH3 -H
285 -CH2CH2CH2CH3 -CH3 -H -CH2CH2CH2CH3 -CH3 -H
286 -CH(CH3)CH2CH3 -CH3 -H -CH(CH3)CH2CH3 -CH3 -H
287 -CH2CH(CH3)2 -CH3 -H -CH2CH(CH3)2 -CH3 -H
288 -C(CH3)3 -CH3 -H -C(CH3)3 -CH3 -H
289 -H -CH3 -CH3 -H -CH3 -CH3
290 -CH3 -CH3 -CH3 -CH3 -CH3 -CH3
291 -CH2CH3 -CH3 -CH3 -CH2CH3 -CH3 -CH3
292 -CH2CH2CH3 -CH3 -CH3 -CH2CH2CH3 -CH3 -CH3
293 -CH(CH3)2 -CH3 -CH3 -CH(CH3)2 -CH3 -CH3
294 -CH2CH2CH2CH3 -CH3 -CH3 -CH2CH2CH2CH3 -CH3 -CH3
295 -CH(CH3)CH2CH3 -CH3 -CH3 -CH(CH3)CH2CH3 -CH3 -CH3
296 -CH2CH(CH3)2 -CH3 -CH3 -CH2CH(CH3)2 -CH3 -CH3
297 -C(CH3)3 -CH3 -CH3 -C(CH3)3 -CH3 -CH3
298 -H -CH2CH3 -H -H -CH2CH3 -H
299 -CH3 -CH2CH3 -H -CH3 -CH2CH3 -H
300 -CH2CH3 -CH2CH3 -H -CH2CH3 -CH2CH3 -H
301 -CH2CH2CH3 -CH2CH3 -H -CH2CH2CH3 -CH2CH3 -H
302 -CH(CH3)2 -CH2CH3 -H -CH(CH3)2 -CH2CH3 -H
303 -CH2CH2CH2CH3 -CH2CH3 -H -CH2CH2CH2CH3 -CH2CH3 -H
304 -CH(CH3)CH2CH3 -CH2CH3 -H -CH(CH3)CH2CH3 -CH2CH3 -H
305 -CH2CH(CH3)2 -CH2CH3 -H -CH2CH(CH3)2 -CH2CH3 -H
306 -C(CH3)3 -CH2CH3 -H -C(CH3)3 -CH2CH3 -H
307 -H -CH2CH3 -CH3 -H -CH2CH3 -CH3
308 -CH3 -CH2CH3 -CH3 -CH3 -CH2CH3 -CH3
309 -CH2CH3 -CH2CH3 -CH3 -CH2CH3 -CH2CH3 -CH3
310 -CH2CH2CH3 -CH2CH3 -CH3 -CH2CH2CH3 -CH2CH3 -CH3
311 -CH(CH3)2 -CH2CH3 -CH3 -CH(CH3)2 -CH2CH3 -CH3
312 -CH2CH2CH2CH3 -CH2CH3 -CH3 -CH2CH2CH2CH3 -CH2CH3 -CH3
313 -CH(CH3)CH2CH3 -CH2CH3 -CH3 -CH(CH3)CH2CH3 -CH2CH3 -CH3
314 -CH2CH(CH3)2 -CH2CH3 -CH3 -CH2CH(CH3)2 -CH2CH3 -CH3
315 -C(CH3)3 -CH2CH3 -CH3 -C(CH3)3 -CH2CH3 -CH3
316 -H -CH2CH3 -CH2CH3 -H -CH2CH3 -CH2CH3
317 -CH3 -CH2CH3 -CH2CH3 -CH3 -CH2CH3 -CH2CH3
318 -CH2CH3 -CH2CH3 -CH2CH3 -CH2CH3 -CH2CH3 -CH2CH3
319 -CH2CH2CH3 -CH2CH3 -CH2CH3 -CH2CH2CH3 -CH2CH3 -CH2CH3
320 -CH(CH3)2 -CH2CH3 -CH2CH3 -CH(CH3)2 -CH2CH3 -CH2CH3
321 -CH2CH2CH2CH3 -CH2CH3 -CH2CH3 -CH2CH2CH2CH3 -CH2CH3 -CH2CH3
322 -CH(CH3)CH2CH3 -CH2CH3 -CH2CH3 -CH(CH3)CH2CH3 -CH2CH3 -CH2CH3
323 -CH2CH(CH3)2 -CH2CH3 -CH2CH3 -CH2CH(CH3)2 -CH2CH3 -CH2CH3
324 -C(CH3)3 -CH2CH3 -CH2CH3 -C(CH3)3 -CH2CH3 -CH2CH3
325 -H -CH2CH2CH3 -H -H -CH2CH2CH3 -H
326 -CH3 -CH2CH2CH3 -H -CH3 -CH2CH2CH3 -H
327 -CH2CH3 -CH2CH2CH3 -H -CH2CH3 -CH2CH2CH3 -H
328 -CH2CH2CH3 -CH2CH2CH3 -H -CH2CH2CH3 -CH2CH2CH3 -H
329 -CH(CH3)2 -CH2CH2CH3 -H -CH(CH3)2 -CH2CH2CH3 -H
330 -CH2CH2CH2CH3 -CH2CH2CH3 -H -CH2CH2CH2CH3 -CH2CH2CH3 -H
331 -CH(CH3)CH2CH3 -CH2CH2CH3 -H -CH(CH3)CH2CH3 -CH2CH2CH3 -H
332 -CH2CH(CH3)2 -CH2CH2CH3 -H -CH2CH(CH3)2 -CH2CH2CH3 -H
333 -C(CH3)3 -CH2CH2CH3 -H -C(CH3)3 -CH2CH2CH3 -H
334 -H -CH2CH2CH3 -CH3 -H -CH2CH2CH3 -CH3
335 -CH3 -CH2CH2CH3 -CH3 -CH3 -CH2CH2CH3 -CH3
336 -CH2CH3 -CH2CH2CH3 -CH3 -CH2CH3 -CH2CH2CH3 -CH3
337 -CH2CH2CH3 -CH2CH2CH3 -CH3 -CH2CH2CH3 -CH2CH2CH3 -CH3
338 -CH(CH3)2 -CH2CH2CH3 -CH3 -CH(CH3)2 -CH2CH2CH3 -CH3
339 -CH2CH2CH2CH3 -CH2CH2CH3 -CH3 -CH2CH2CH2CH3 -CH2CH2CH3 -CH3
340 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH3 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH3
341 -CH2CH(CH3)2 -CH2CH2CH3 -CH3 -CH2CH(CH3)2 -CH2CH2CH3 -CH3
342 -C(CH3)3 -CH2CH2CH3 -CH3 -C(CH3)3 -CH2CH2CH3 -CH3
343 -H -CH2CH2CH3 -CH2CH3 -H -CH2CH2CH3 -CH2CH3
344 -CH3 -CH2CH2CH3 -CH2CH3 -CH3 -CH2CH2CH3 -CH2CH3
345 -CH2CH3 -CH2CH2CH3 -CH2CH3 -CH2CH3 -CH2CH2CH3 -CH2CH3
346 -CH2CH2CH3 -CH2CH2CH3 -CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -CH2CH3
347 -CH(CH3)2 -CH2CH2CH3 -CH2CH3 -CH(CH3)2 -CH2CH2CH3 -CH2CH3
348 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH3 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH3
349 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH3 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH3
350 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH3 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH3
351 -C(CH3)3 -CH2CH2CH3 -CH2CH3 -C(CH3)3 -CH2CH2CH3 -CH2CH3
352 -H -CH2CH2CH3 -CH2CH2CH3 -H -CH2CH2CH3 -CH2CH2CH3
353 -CH3 -CH2CH2CH3 -CH2CH2CH3 -CH3 -CH2CH2CH3 -CH2CH2CH3
354 -CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -CH2CH3 -CH2CH2CH3 -CH2CH2CH3
355 -CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3
356 -CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3
357 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH2CH3 -CH2CH2CH3 -CH2CH2CH3
358 -CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH2CH3 - CH(CH3)CH2CH3 -CH2CH2CH3 -CH2CH2CH3
359 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3 -CH2CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3
360 -C(CH3)3 -CH2CH2CH3 -CH2CH2CH3 -C(CH3)3 -CH2CH2CH3 -CH2CH2CH3
361 -H -CH(CH3)2 -H -H -CH(CH3)2 -H
362 -CH3 -CH(CH3)2 -H -CH3 -CH(CH3)2 -H
363 -CH2CH3 -CH(CH3)2 -H -CH2CH3 -CH(CH3)2 -H
364 -CH2CH2CH3 -CH(CH3)2 -H -CH2CH2CH3 -CH(CH3)2 -H
365 -CH(CH3)2 -CH(CH3)2 -H -CH(CH3)2 -CH(CH3)2 -H
366 -CH2CH2CH2CH3 -CH(CH3)2 -H -CH2CH2CH2CH3 -CH(CH3)2 -H
367 -CH(CH3)CH2CH3 -CH(CH3)2 -H -CH(CH3)CH2CH3 -CH(CH3)2 -H
368 -CH2CH(CH3)2 -CH(CH3)2 -H -CH2CH(CH3)2 -CH(CH3)2 -H
369 -C(CH3)3 -CH(CH3)2 -H -C(CH3)3 -CH(CH3)2 -H
370 -H -CH(CH3)2 -CH3 -H -CH(CH3)2 -CH3
371 -CH3 -CH(CH3)2 -CH3 -CH3 -CH(CH3)2 -CH3
372 -CH2CH3 -CH(CH3)2 -CH3 -CH2CH3 -CH(CH3)2 -CH3
373 -CH2CH2CH3 -CH(CH3)2 -CH3 -CH2CH2CH3 -CH(CH3)2 -CH3
374 -CH(CH3)2 -CH(CH3)2 -CH3 -CH(CH3)2 -CH(CH3)2 -CH3
375 -CH2CH2CH2CH3 -CH(CH3)2 -CH3 -CH2CH2CH2CH3 -CH(CH3)2 -CH3
376 -CH(CH3)CH2CH3 -CH(CH3)2 -CH3 -CH(CH3)CH2CH3 -CH(CH3)2 -CH3
377 -CH2CH(CH3)2 -CH(CH3)2 -CH3 -CH2CH(CH3)2 -CH(CH3)2 -CH3
378 -C(CH3)3 -CH(CH3)2 -CH3 -C(CH3)3 -CH(CH3)2 -CH3
379 -H -CH(CH3)2 -CH2CH3 -H -CH(CH3)2 -CH2CH3
380 -CH3 -CH(CH3)2 -CH2CH3 -CH3 -CH(CH3)2 -CH2CH3
381 -CH2CH3 -CH(CH3)2 -CH2CH3 -CH2CH3 -CH(CH3)2 -CH2CH3
382 -CH2CH2CH3 -CH(CH3)2 -CH2CH3 -CH2CH2CH3 -CH(CH3)2 -CH2CH3
383 -CH(CH3)2 -CH(CH3)2 -CH2CH3 -CH(CH3)2 -CH(CH3)2 -CH2CH3
384 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH3 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH3
385 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH3 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH3
386 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH3 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH3
387 -C(CH3)3 -CH(CH3)2 -CH2CH3 -C(CH3)3 -CH(CH3)2 -CH2CH3
388 -H -CH(CH3)2 -CH2CH2CH3 -H -CH(CH3)2 -CH2CH2CH3
389 -CH3 -CH(CH3)2 -CH2CH2CH3 -CH3 -CH(CH3)2 -CH2CH2CH3
390 -CH2CH3 -CH(CH3)2 -CH2CH2CH3 -CH2CH3 -CH(CH3)2 -CH2CH2CH3
391 -CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3 -CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3
392 -CH(CH3)2 -CH(CH3)2 -CH2CH2CH3 -CH(CH3)2 -CH(CH3)2 -CH2CH2CH3
393 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3 -CH2CH2CH2CH3 -CH(CH3)2 -CH2CH2CH3
394 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH2CH3 -CH(CH3)CH2CH3 -CH(CH3)2 -CH2CH2CH3
395 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH2CH3 -CH2CH(CH3)2 -CH(CH3)2 -CH2CH2CH3
396 -C(CH3)3 -CH(CH3)2 -CH2CH2CH3 -C(CH3)3 -CH(CH3)2 -CH2CH2CH3
397 -H -CH(CH3)2 -CH(CH3)2 -H -CH(CH3)2 -CH(CH3)2
398 -CH3 -CH(CH3)2 -CH(CH3)2 -CH3 -CH(CH3)2 -CH(CH3)2
399 -CH2CH3 -CH(CH3)2 -CH(CH3)2 -CH2CH3 -CH(CH3)2 -CH(CH3)2
400 -CH2CH2CH3 -CH(CH3)2 -CH(CH3)2 -CH2CH2CH3 -CH(CH3)2 -CH(CH3)2
401 -CH(CH3)2 -CH(CH3)2 -CH(CH3)2 -CH(CH3)2 -CH(CH3)2 -CH(CH3)2
402 -CH2CH2CH2CH3 -CH(CH3)2 -CH(CH3)2 -CH2CH2CH2CH3 -CH(CH3)2 -CH(CH3)2
403 -CH(CH3)CH2CH3 -CH(CH3)2 -CH(CH3)2 -CH(CH3)CH2CH3 -CH(CH3)2 -CH(CH3)2
404 -CH2CH(CH3)2 -CH(CH3)2 -CH(CH3)2 -CH2CH(CH3)2 -CH(CH3)2 -CH(CH3)2
405 -C(CH3)3 -CH(CH3)2 -CH(CH3)2 -C(CH3)3 -CH(CH3)2 -CH(CH3)2
Individual species satisfying the above formula are listed in Table 3 below with respect to their residues R7 to R12. These are particularly preferred according to the invention. Table 3: Preferred carvone acetals No. R7 R8 R9 R10 R11 R12
1 -H -H -H -H -H -H
2 -CH 3 -H -H -H -H -H
3 -CH 2 CH 3 -H -H -H -H -H
4 -CH 2 CH 2 CH 3 -H -H -H -H -H
5 -CH (CH 3 ) 2 -H -H -H -H -H
6 -CH 2 CH 2 CH 2 CH 3 -H -H -H -H -H
7 -CH (CH 3 ) CH 2 CH 3 -H -H -H -H -H
8th -CH 2 CH (CH 3 ) 2 -H -H -H -H -H
9 -C (CH 3 ) 3 -H -H -H -H -H
10 -H -CH 3 -H -H -H -H
11 -CH 3 -CH 3 -H -H -H -H
12 -CH 2 CH 3 -CH 3 -H -H -H -H
13 -CH 2 CH 2 CH 3 -CH 3 -H -H -H -H
14 -CH (CH 3 ) 2 -CH 3 -H -H -H -H
15 -CH 2 CH 2 CH 2 CH 3 -CH 3 -H -H -H -H
16 -CH (CH 3 ) CH 2 CH 3 -CH 3 -H -H -H -H
17 -CH 2 CH (CH 3 ) 2 -CH 3 -H -H -H -H
18 -C (CH 3 ) 3 -CH 3 -H -H -H -H
19 -H -CH 3 -CH 3 -H -H -H
20 -CH 3 -CH 3 -CH 3 -H -H -H
21 -CH 2 CH 3 -CH 3 -CH 3 -H -H -H
22 -CH 2 CH 2 CH 3 -CH 3 -CH 3 -H -H -H
23 -CH (CH 3 ) 2 -CH 3 -CH 3 -H -H -H
24 -CH 2 CH 2 CH 2 CH 3 -CH 3 -CH 3 -H -H -H
25 -CH (CH 3 ) CH 2 CH 3 -CH 3 -CH 3 -H -H -H
26 -CH 2 CH (CH 3 ) 2 -CH 3 -CH 3 -H -H -H
27 -C (CH 3 ) 3 -CH 3 -CH 3 -H -H -H
28 -H -CH 2 CH 3 -H -H -H -H
29 -CH 3 -CH 2 CH 3 -H -H -H -H
30 -CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
31 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
32 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H -H
33 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
34 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
35 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H -H
36 -C (CH 3 ) 3 -CH 2 CH 3 -H -H -H -H
37 -H -CH 2 CH 3 -CH 3 -H -H -H
38 -CH 3 -CH 2 CH 3 -CH 3 -H -H -H
39 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
40 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
41 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 3 -H -H -H
42 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
43 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
44 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 3 -H -H -H
45 -C (CH 3 ) 3 -CH 2 CH 3 -CH 3 -H -H -H
46 -H -CH 2 CH 3 -CH 2 CH 3 -H -H -H
47 -CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
48 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
49 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
50 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
51 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
52 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
53 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
54 -C (CH 3 ) 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
55 -H -CH 2 CH 2 CH 3 -H -H -H -H
56 -CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
57 -CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
58 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
59 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H -H
60 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
61 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
62 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H -H
63 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -H -H -H -H
64 -H -CH 2 CH 2 CH 3 -CH 3 -H -H -H
65 -CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
66 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
67 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
68 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
69 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
70 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
71 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
72 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
73 -H -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
74 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
75 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
76 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
77 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
78 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
79 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
80 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
81 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
82 -H -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
83 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
84 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
85 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
86 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
87 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
88 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
89 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
90 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
91 -H -CH (CH 3 ) 2 -H -H -H -H
92 -CH 3 -CH (CH 3 ) 2 -H -H -H -H
93 -CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
94 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
95 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H -H
96 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
97 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
98 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H -H
99 -C (CH 3 ) 3 -CH (CH 3 ) 2 -H -H -H -H
100 -H -CH (CH 3 ) 2 -CH 3 -H -H -H
101 -CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
102 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
103 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
104 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3 -H -H -H
105 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
106 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
107 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3 -H -H -H
108 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
109 -H -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
110 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
111 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
112 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
113 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
114 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
115 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
116 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
117 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
118 -H -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
119 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
120 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
121 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
122 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
123 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
124 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
125 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
126 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
127 -H -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
128 -CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
129 -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
130 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
131 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
132 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
133 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
134 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
135 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
No. R10 R11 R12 R7 R8 R9
136 -H -H -H -H -H -H
137 -CH 3 -H -H -H -H -H
138 -CH 2 CH 3 -H -H -H -H -H
139 -CH 2 CH 2 CH 3 -H -H -H -H -H
140 -CH (CH 3 ) 2 -H -H -H -H -H
141 -CH 2 CH 2 CH 2 CH 3 -H -H -H -H -H
142 -CH (CH 3 ) CH 2 CH 3 -H -H -H -H -H
143 -CH 2 CH (CH 3 ) 2 -H -H -H -H -H
144 -C (CH 3 ) 3 -H -H -H -H -H
145 -H -CH 3 -H -H -H -H
146 -CH 3 -CH 3 -H -H -H -H
147 -CH 2 CH 3 -CH 3 -H -H -H -H
148 -CH 2 CH 2 CH 3 -CH 3 -H -H -H -H
149 -CH (CH 3 ) 2 -CH 3 -H -H -H -H
150 -CH 2 CH 2 CH 2 CH 3 -CH 3 -H -H -H -H
151 -CH (CH 3 ) CH 2 CH 3 -CH 3 -H -H -H -H
152 -CH 2 CH (CH 3 ) 2 -CH 3 -H -H -H -H
153 -C (CH 3 ) 3 -CH 3 -H -H -H -H
154 -H -CH 3 -CH 3 -H -H -H
155 -CH 3 -CH 3 -CH 3 -H -H -H
156 -CH 2 CH 3 -CH 3 -CH 3 -H -H -H
157 -CH 2 CH 2 CH 3 -CH 3 -CH 3 -H -H -H
158 -CH (CH 3 ) 2 -CH 3 -CH 3 -H -H -H
159 -CH 2 CH 2 CH 2 CH 3 -CH 3 -CH 3 -H -H -H
160 -CH (CH 3 ) CH 2 CH 3 -CH 3 -CH 3 -H -H -H
161 -CH 2 CH (CH 3 ) 2 -CH 3 -CH 3 -H -H -H
162 -C (CH 3 ) 3 -CH 3 -CH 3 -H -H -H
163 -H -CH 2 CH 3 -H -H -H -H
164 -CH 3 -CH 2 CH 3 -H -H -H -H
165 -CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
166 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
167 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H -H
168 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
169 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -H -H -H -H
170 -CHzCH (CH 3 ) 2 -CH 2 CH 3 -H -H -H -H
171 -C (CH 3 ) 3 -CH 2 CH 3 -H -H -H -H
172 -H -CH 2 CH 3 -CH 3 -H -H -H
173 -CH 3 -CH 2 CH 3 -CH 3 -H -H -H
174 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
175 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
176 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 3 -H -H -H
177 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
178 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 3 -H -H -H
179 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 3 -H -H -H
180 -C (CH 3 ) 3 -CH 2 CH 3 -CH 3 -H -H -H
181 -H -CH 2 CH 3 -CH 2 CH 3 -H -H -H
182 -CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
183 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
184 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
185 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
186 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
187 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
188 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
189 -C (CH 3 ) 3 -CH 2 CH 3 -CH 2 CH 3 -H -H -H
190 -H -CH 2 CH 2 CH 3 -H -H -H -H
191 -CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
192 -CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
193 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
194 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H -H
195 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
196 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H -H
197 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H -H
198 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -H -H -H -H
199 -H -CH 2 CH 2 CH 3 -CH 3 -H -H -H
200 -CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
201 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
202 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
203 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
204 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
205 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
206 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
207 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 3 -H -H -H
208 -H -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
209 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
210 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
211 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
212 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
213 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
214 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
215 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
216 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -H -H
217 -H -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
218 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
219 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
220 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
221 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
222 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
223 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
224 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
225 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -H -H
226 -H -CH (CH 3 ) 2 -H -H -H -H
227 -CH 3 -CH (CH 3 ) 2 -H -H -H -H
228 -CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
229 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
230 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H -H
231 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
232 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -H -H -H -H
233 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H -H
234 -C (CH 3 ) 3 -CH (CH 3 ) 2 -H -H -H -H
235 -H -CH (CH 3 ) 2 -CH 3 -H -H -H
236 -CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
237 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
238 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
239 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3 -H -H -H
240 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
241 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
242 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3 -H -H -H
243 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 3 -H -H -H
244 -H -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
245 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
246 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
247 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
248 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
249 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
250 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
251 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
252 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 3 -H -H -H
253 -H -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
254 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
255 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
256 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
257 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
258 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
259 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
260 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
261 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -H -H
262 -H -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
263 -CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
264 -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
265 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
266 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
267 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
268 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -H -H
269 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 - CH (CH 3 ) 2 -H -H -H
270 -C (CH 3 ) 3 -CH (CH 3 ) 2 - CH (CH 3 ) 2 -H -H -H
No. R7 R8 R9 R10 R11 R12
271 -H -H -H -H -H -H
272 -CH 3 -H -H -CH 3 -H -H
273 -CH 2 CH 3 -H -H -CH 2 CH 3 -H -H
274 -CH 2 CH 2 CH 3 -H -H -CH 2 CH 2 CH 3 -H -H
275 -CH (CH 3 ) 2 -H -H -CH (CH 3 ) 2 -H -H
276 -CH 2 CH 2 CH 2 CH 3 -H -H -CH 2 CH 2 CH 2 CH 3 -H -H
277 -H (CH 3 ) CH 2 CH 3 -H -H -CH (CH 3 ) CH 2 CH 3 -H -H
278 -CH 2 CH (CH 3 ) 2 -H -H -CH 2 CH (CH 3 ) 2 -H -H
279 -C (CH 3 ) 3 -H -H -C (CH 3 ) 3 -H -H
280 -H -CH 3 -H -H -CH 3 -H
281 -CH 3 -CH 3 -H -CH 3 -CH 3 -H
282 -CH 2 CH 3 -CH 3 -H -CH 2 CH 3 -CH 3 -H
283 -CH 2 CH 2 CH 3 -CH 3 -H -CH 2 CH 2 CH 3 -CH 3 -H
284 -CH (CH 3 ) 2 -CH 3 -H -CH (CH 3 ) 2 -CH 3 -H
285 -CH 2 CH 2 CH 2 CH 3 -CH 3 -H -CH 2 CH 2 CH 2 CH 3 -CH 3 -H
286 -CH (CH 3 ) CH 2 CH 3 -CH 3 -H -CH (CH 3 ) CH 2 CH 3 -CH 3 -H
287 -CH 2 CH (CH 3 ) 2 -CH 3 -H -CH 2 CH (CH 3 ) 2 -CH 3 -H
288 -C (CH 3 ) 3 -CH 3 -H -C (CH 3 ) 3 -CH 3 -H
289 -H -CH 3 -CH 3 -H -CH 3 -CH 3
290 -CH 3 -CH 3 -CH 3 -CH 3 -CH 3 -CH 3
291 -CH 2 CH 3 -CH 3 -CH 3 -CH 2 CH 3 -CH 3 -CH 3
292 -CH 2 CH 2 CH 3 -CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH 3 -CH 3
293 -CH (CH 3 ) 2 -CH 3 -CH 3 -CH (CH 3 ) 2 -CH 3 -CH 3
294 -CH 2 CH 2 CH 2 CH 3 -CH 3 -CH 3 -CH 2 CH 2 CH 2 CH 3 -CH 3 -CH 3
295 -CH (CH 3 ) CH 2 CH 3 -CH 3 -CH 3 -CH (CH 3 ) CH 2 CH 3 -CH 3 -CH 3
296 -CH 2 CH (CH 3 ) 2 -CH 3 -CH 3 -CH 2 CH (CH 3 ) 2 -CH 3 -CH 3
297 -C (CH 3 ) 3 -CH 3 -CH 3 -C (CH 3 ) 3 -CH 3 -CH 3
298 -H -CH 2 CH 3 -H -H -CH 2 CH 3 -H
299 -CH 3 -CH 2 CH 3 -H -CH 3 -CH 2 CH 3 -H
300 -CH 2 CH 3 -CH 2 CH 3 -H -CH 2 CH 3 -CH 2 CH 3 -H
301 -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -CH 2 CH 2 CH 3 -CH 2 CH 3 -H
302 -CH (CH 3 ) 2 -CH 2 CH 3 -H -CH (CH 3 ) 2 -CH 2 CH 3 -H
303 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -H -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -H
304 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -H -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -H
305 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -H -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -H
306 -C (CH 3 ) 3 -CH 2 CH 3 -H -C (CH 3 ) 3 -CH 2 CH 3 -H
307 -H -CH 2 CH 3 -CH 3 -H -CH 2 CH 3 -CH 3
308 -CH 3 -CH 2 CH 3 -CH 3 -CH 3 -CH 2 CH 3 -CH 3
309 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 3
310 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3
311 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 3
312 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3
313 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 3
314 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 3 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 3
315 -C (CH 3 ) 3 -CH 2 CH 3 -CH 3 -C (CH 3 ) 3 -CH 2 CH 3 -CH 3
316 -H -CH 2 CH 3 -CH 2 CH 3 -H -CH 2 CH 3 -CH 2 CH 3
317 -CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 3 -CH 2 CH 3
318 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3
319 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3
320 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3
321 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3
322 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3
323 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3
324 -C (CH 3 ) 3 -CH 2 CH 3 -CH 2 CH 3 -C (CH 3 ) 3 -CH 2 CH 3 -CH 2 CH 3
325 -H -CH 2 CH 2 CH 3 -H -H -CH 2 CH 2 CH 3 -H
326 -CH 3 -CH 2 CH 2 CH 3 -H -CH 3 -CH 2 CH 2 CH 3 -H
327 -CH 2 CH 3 -CH 2 CH 2 CH 3 -H -CH 2 CH 3 -CH 2 CH 2 CH 3 -H
328 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H
329 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H
330 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H
331 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -H -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -H
332 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H
333 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -H -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -H
334 -H -CH 2 CH 2 CH 3 -CH 3 -H -CH 2 CH 2 CH 3 -CH 3
335 -CH 3 -CH 2 CH 2 CH 3 -CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH 3
336 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3
337 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3
338 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3
339 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3
340 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3
341 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3
342 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 3 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 3
343 -H -CH 2 CH 2 CH 3 -CH 2 CH 3 -H -CH 2 CH 2 CH 3 -CH 2 CH 3
344 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3
345 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3
346 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3
347 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3
348 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3
349 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3
350 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3
351 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 3
352 -H -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -H -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
353 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
354 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
355 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
356 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
357 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
358 -CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 - CH (CH 3 ) CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
359 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH 2 CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
360 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -C (CH 3 ) 3 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3
361 -H -CH (CH 3 ) 2 -H -H -CH (CH 3 ) 2 -H
362 -CH 3 -CH (CH 3 ) 2 -H -CH 3 -CH (CH 3 ) 2 -H
363 -CH 2 CH 3 -CH (CH 3 ) 2 -H -CH 2 CH 3 -CH (CH 3 ) 2 -H
364 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H
365 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H
366 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -H
367 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -H -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -H
368 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -H
369 -C (CH 3 ) 3 -CH (CH 3 ) 2 -H -C (CH 3 ) 3 -CH (CH 3 ) 2 -H
370 -H -CH (CH 3 ) 2 -CH 3 -H -CH (CH 3 ) 2 -CH 3
371 -CH 3 -CH (CH 3 ) 2 -CH 3 -CH 3 -CH (CH 3 ) 2 -CH 3
372 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 3
373 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3
374 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3
375 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 3
376 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 3 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 3
377 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3
378 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 3 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 3
379 -H -CH (CH 3 ) 2 -CH 2 CH 3 -H -CH (CH 3 ) 2 -CH 2 CH 3
380 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 3
381 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3
382 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3
383 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3
384 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3
385 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 3
386 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3
387 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 3 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 3
388 -H -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -H -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
389 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
390 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
391 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
392 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
393 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
394 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
395 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
396 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3
397 -H -CH (CH 3 ) 2 -CH (CH 3 ) 2 -H -CH (CH 3 ) 2 -CH (CH 3 ) 2
398 -CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
399 -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
400 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
401 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2
402 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH 2 CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
403 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) CH 2 CH 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
404 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH 2 CH (CH 3 ) 2 -CH (CH 3 ) 2 -CH (CH 3 ) 2
405 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2 -C (CH 3 ) 3 -CH (CH 3 ) 2 -CH (CH 3 ) 2
Zusammenfassend sind erfindungsgemäße Mund- und Zahnpflege- und -reinigungsmittel bevorzugt, die mindestens einen Scharfstoff aus den Gruppen der
- alkylsubstituierten Dioxane der Formel
in der R1 und R2 unabhängig voneinander ausgewählt sind aus -H, -CH3, - CH2CH3 und R3 und R4 unabhängig voneinander ausgewählt sind aus -H, -CH3, - CH2CH3, -CH2CH2CH3, -CH(CH3)2 und/oder
- Phenylestern der Formel
in der R5 für -CH3 oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen und R6 für -CH3 oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen oder eine Alkoxygruppe mit 1 bis 3 Kohlenstoffatomen steht und/oder
- Carvonacetalen der Formel
in der R7 bis R12 unabhängig voneinander ausgewählt sind aus -H, -CH3, -CH2CH3, -CH2CH2CH3, -CH(CH3)2, -CH2 CH2CH2CH3, -CH2CH(CH3)2, -CH(CH3)CH2CH3, - C(CH3)3 oder R9 und R10 zusammen eine chemiche Bindung oder eine Gruppe - (CR13R14)x bedeuten, worin x für die Werte 1 oder 2 steht und R13 und R14 unabhängig voneinander ausgewählt sind aus -H, -CH3, -CH2CH3, -CH2CH2CH3, - CH(CH3)2, -CH2 CH2CH2CH3, -CH2CH(CH3)2, -CH(CH3)CH2CH3-C(CH3)3
enthalten.
In summary, oral and dental care and cleaning compositions according to the invention are preferred, which are at least one Scharfstoff from the groups of - alkyl-substituted dioxanes of the formula in which R1 and R2 are independently selected from -H, -CH 3, - CH 2 CH 3 and R3 and R4 are independently selected from -H, -CH 3, - CH 2 CH 3, -CH 2 CH 2 CH 3 , -CH (CH 3 ) 2 and / or
- Phenyl esters of the formula is in which R 5 is -CH 3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms, and R6 is -CH3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms or an alkoxy group having 1 to 3 carbon atoms and or
- Carvone acetals of the formula in which R 7 to R 12 are independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH (CH 3 ) 2 , -CH 2 CH 2 CH 2 CH 3 , - CH 2 CH (CH 3 ) 2 , -CH (CH 3 ) CH 2 CH 3 , -C (CH 3 ) 3 or R 9 and R 10 together represent a chemical bond or a group - (CR 13 R 14) x , where x is the values 1 or 2 and R 13 and R 14 are independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH (CH 3 ) 2 , -CH 2 CH 2 CH 2 CH 3 , -CH 2 CH (CH 3 ) 2 , -CH (CH 3 ) CH 2 CH 3 -C (CH 3 ) 3
contain.
Die erfindungsgemäßen Mund- und Zahnpflege- und -reinigungsmittel können zusätzlich zu den vorstehend genannten wesentlichen Inhaltsstoffen weitere Inhaltsstoffe von Mundreinigungsmitteln, Mundpflegemitteln, Zahnreinigungsmitteln und/oder Zahnpflegemitteln enthalten. Die bevorzugten weiteren Inhaltsstoffe werden nachstehend beschrieben.The oral and dental care and cleaning compositions according to the invention may contain, in addition to the aforementioned essential ingredients, other ingredients of oral cleansers, oral hygiene products, dentifrices and / or dentifrices. The preferred further ingredients are described below.
Die erfindungsgemäßen Mittel, insbesondere die Zahnpasten oder flüssigen Zahncremes enthalten vorzugsweise ein oder mehrere Poliermittel, üblicherweise in einer Menge von 5 bis 50 Gew.-%.The compositions according to the invention, in particular toothpastes or liquid toothpastes, preferably contain one or more polishing agents, usually in an amount of from 5 to 50% by weight.
Als Poliermittel eignen sich prinzipiell alle für Zahnpasten bekannten Reibkörper, insbesondere solche, die keine Calciumionen enthalten. Bevorzugt geeignete Poliermittel-komponenten sind daher Kieselsäuren, Aluminiumhydroxid, Aluminiumoxid, Natrium-aluminiumsilikate, organische Polymere oder Gemische solcher Reibkörper.As a polishing agent are in principle all known for toothpastes friction body, in particular those that do not contain calcium ions. Preferably suitable polishing agent components are therefore silicic acids, aluminum hydroxide, aluminum oxide, sodium aluminum silicates, organic polymers or mixtures of such friction bodies.
Calciumhaltige Polierkomponenten wie z.B. Kreide, Calciumpyrophosphat, Dicalcium-phosphatdihydrat können aber in Mengen bis zu 5 Gew.-% enthalten sein.Calcium containing polishing components such as e.g. However, chalk, calcium pyrophosphate, dicalcium phosphate dihydrate can be present in amounts of up to 5% by weight.
Der Gesamtgehalt an Poliermitteln liegt vorzugsweise im Bereich von 5-50 Gew.-% des Zahnpflegemittels.The total content of polishing agents is preferably in the range of 5-50% by weight of the dentifrice.
Besonders bevorzugt sind Zahnpasten und flüssige Zahnreinigungsmittel, die als Polier-mittel Kieselsäuren enthalten. Geeignete Kieselsäuren sind z.B. Gelkieselsäuren, Hydrogelkieselsäuren und Fällungskieselsäuren. Gelkieselsäuren werden durch Umsetzung von Natriumsilikatlösungen mit starken, wäßrigen Mineralsäuren unter Ausbildung eines Hydrosols, Alterung zum Hydrogel, Waschen und Trocknen hergestellt. Erfolgt die Trocknung unter schonenden Bedingungen auf Wassergehalt von 15 bis 35 Gew.-%, so werden die sogenannten Hydrogelkieselsäuren erhalten. Durch Trocknung auf Wassergehalte unterhalb 15 Gew.-% erfolgt eine irreversible Schrumpfung der vorher lockeren Struktur des Hydrogels zur dichten Struktur des sog. Xerogels.Particular preference is given to toothpastes and liquid dentifrices which contain silicic acids as a polishing agent. Suitable silicas are e.g. Gel silicas, hydrogel silicas and precipitated silicas. Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and drying. If the drying is carried out under mild conditions to a water content of 15 to 35 wt .-%, the so-called hydrogel silicic acids are obtained. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.
Eine zweite, bevorzugt geeignete Gruppe von Kieselsäure-Poliermitteln sind die Fällungskieselsäuren. Diese werden durch Ausfällung von Kieselsäure aus verdünnten Alkalisilikat-Lösungen durch Zugabe von starken Säuren unter Bedingungen erhalten, bei welchen die Aggregation zum Sol und Gel nicht eintreten kann. Geeignete Verfahren zur Bevorzugt geeignet ist eine Fällungskieselsäure mit einer BET-Oberfläche von 15 - 110 m2/g, einer Partikelgröße von 0,5 - 20 µm, wobei wenigstens 80 Gew.-% der Primärpartikel unter 5 µm liegen sollen, und einer Viskosität in 30 %iger Glycerin-Wasser-(1 : 1)-Dispersion von 30 - 60 Pa.s (20°C) in einer Menge von 10-20 Gew.-% der Zahnpaste. Bevorzugt geeignete Fällungskieselsäuren dieser Art weisen außerdem gerundete Ecken und Kanten auf und sind unter der Handelsbezeichnung Sident12 DS (DEGUSSA) erhältlich.A second, preferably suitable group of silica polishing agents are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which the Aggregation to the sol and gel can not occur. Suitable methods for preferably suitable is a precipitated silica having a BET surface area of 15 - 110 m2 / g, a particle size of 0.5 - 20 microns, wherein at least 80 wt .-% of the primary particles should be less than 5 microns, and a viscosity in 30% glycerol-water (1: 1) dispersion of 30-60 Pa.s (20 ° C) in an amount of 10-20% by weight of the dentifrice. Preferred precipitated silicas of this type also have rounded corners and edges and are available under the trade name Sident12 DS (DEGUSSA).
Andere Fällungskieselsäuren dieser Art sind Sident 8 (DEGUSSA) und Sorbosil AC 39 (Crosfield Chemicals). Diese Kieselsäuren zeichnen sich durch eine geringere Verdickungswirkung und eine etwas höhere mittlere Teilchengröße von 8 -14 µm bei einer spezifischen Oberfläche von 40 - 75 m2/g (nach BET) aus und eignen sich besonders gut für flüssige Zahncremes. Diese sollten eine Viskosität (25°C, Scherrate D = 10 s-1) von 10 -100 Pa.s aufweisen.Other precipitated silicas of this type are Sident 8 (DEGUSSA) and Sorbosil AC 39 (Crosfield Chemicals). These silicas are characterized by a lower thickening effect and a slightly higher average particle size of 8-14 microns with a specific surface area of 40 - 75 m2 / g (according to BET) and are particularly well suited for liquid toothpastes. These should have a viscosity (25 ° C, shear rate D = 10 s-1) of 10 -100 Pa.s.
Zahnpasten, die eine deutlich höhere Viskosität von mehr als 100 Pa.s (25° C, D = 10 s-1) aufweisen, benötigen hingegen einen genügend hohen Anteil an Kieselsäuren mit einer Teilchengröße von weniger als 5 µm, bevorzugt wenigstens 3 Gew.-% einer Kieselsäure mit einer Partikelgröße von 1 - 3 µm. Solchen Zahnpasten setzt man daher bevorzugt neben den genannten Fällungskieselsäuren noch feinteiligere, sogenannte Verdickungs-kieselsäuren mit einer BET-Oberfläche von 150 -250 m2/g zu, z.B. die Handelsprodukte Sipernat 22 LS oder Sipernat 320 DS.On the other hand, toothpastes which have a significantly higher viscosity of more than 100 Pa.s (25 ° C., D = 10 s-1) require a sufficiently high proportion of silicas having a particle size of less than 5 μm, preferably at least 3% by weight. -% of a silica with a particle size of 1 - 3 microns. To such toothpastes, it is therefore preferable to add finely divided, so-called thickened silicas having a BET surface area of 150-250 m 2 / g, in addition to the precipitated silicas mentioned, for example. the commercial products Sipernat 22 LS or Sipernat 320 DS.
Als weitere Poliermittelkomponente kann auch z.B. Aluminiumoxid in Form von schwach calcinierter Tonerde mit einem Gehalt an - und -Aluminiumoxid in einer Menge von ca. 1 - 5 Gew.-% enthalten sein. Ein solches geeignetes Aluminiumoxid ist unter der Handelsbezeichnung "Poliertonerde P10 feinst" (Giulini Chemie) erhältlich.As a further polishing agent component, e.g. Aluminum oxide in the form of weakly calcined clay containing - and -Aluminiumoxid in an amount of about 1-5 wt .-%. Such a suitable alumina is available under the trade designation "Polianton earth P10 finest" (Giulini Chemie).
Als Poliermittel eignen sich weiter alle für Zahnpasten bekannten Reibkörper wie z. B. Natriumaluminiumsilikate wie z. B. Zeolith A, organische Polymere wie z. B. Polymethacrylat oder Gemische dieser und der vorstehend genannten Reibkörper.As a polishing agent are all further known for toothpastes friction body such. B. sodium aluminum silicates such. As zeolite A, organic polymers such. As polymethacrylate or mixtures of these and the aforementioned friction body.
Zusammenfassend sind erfindungsgemäße Mund- und Zahnpflege- und -reinigungsmittel bevorzugt, die zusätzlich Putzkörper, vorzugsweise Kieselsäuren, Aluminiumhydroxid, Aluminiumoxid, Calciumpyrophosphat, Kreide, Dicalciumphosphat-dihydrat (CaHPO4 -2H2O), Natriumaluminiumsilikate, insbesondere Zeolith A, organische Polymere, insbesondere Polymethacrylate oder Gemische dieser Reibkörper,vorzugsweise in Mengen von 1 bis 30 Gew.%, vorzugsweise von 2,5 bis 25 Gew.% und insbesondere von 5 bis 20 Gew.%, jeweils bezogen auf das gesamte Mittel, enthalten.In summary, oral and dental care and cleaning compositions according to the invention are preferred which additionally comprise cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO 4 -2H 2 O), sodium aluminum silicates, in particular zeolite A, organic polymers, in particular Polymethacrylates or mixtures of these friction bodies, preferably in amounts of 1 to 30 wt.%, Preferably from 2.5 to 25 wt.% And in particular from 5 to 20 wt.%, Each based on the total agent.
Die erfindungsgemäßen Mund- und Zahnpflege- und reinigungsmittel, insbesondere die Zahnpasten, können z. B. auch antimikrobielle Stoffe als Konservierungsmittel oder als Antiplaque-Wirkstoffe enthalten. Derartige Stoffe können z. B. ausgewählt sein aus p-Hydroxybenzoesäuremethyl-, -ethyl- oder propylester, Natriumsorbat, Natriumbenzoat, Bromchlorophen, Triclosan, Phenyl- Salicylsäureester, Biguanide z. B. Chlorhexidin, Thymol usw.. Erfindungsgemäß bevorzugte Mund- und Zahnpflege- und -reinigungsmittel sind dadurch gekennzeichnet, daß sie zusätzlich Antiplaque-Wirkstoffe, vorzugsweise p-Hydroxybenzoesäuremethyl-, -ethyl- oder propylester, Natriumsorbat, Natriumbenzoat, Bromchlorophen, Triclosan, Phenyl- Salicylsäureester, Biguanide z. B. Chlorhexidin, Thymol, vorzugsweise in Mengen von 0,1 bis 5 Gew.%, vorzugsweise von 0,25 bis 2,5 Gew.% und insbesondere von 0,5 bis 1,5 Gew.%, jeweils bezogen auf das gesamte Mittel, enthalten.The oral and dental care and cleaning agents according to the invention, in particular the toothpastes, z. B. also contain antimicrobial substances as preservatives or as antiplaque agents. Such substances may, for. B. be selected from p-Hydroxybenzoesäuremethyl-, ethyl or propyl ester, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylates, biguanides z. Chlorhexidine, thymol, etc. According to the invention preferred oral and Zahnpflege- and -reinigungsmittel are characterized in that they additionally Antiplaque agents, preferably p-Hydroxybenzoesäuremethyl-, ethyl or propyl esters, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl Salicylic acid esters, biguanides z. B. chlorhexidine, thymol, preferably in amounts of 0.1 to 5 wt.%, Preferably from 0.25 to 2.5 wt.% And in particular from 0.5 to 1.5 wt.%, Each based on the total Means, included.
Eine weitere bevorzugte Gruppe von Inhaltsstoffen, die in den erfindungsgemäßen Mitteln enthalten sein kann, sind die Antikaries-Wirkstoffe. Diese können beispielsweise aus organischen oder anorganischen Fluoriden ausgewählt sein, z. B. aus Natriumfluorid, Kaliumfluorid, Natriummonofluorphosphat und Natriumfluorosilikat. Auch Zinkfluorid, Zinn-(II)-fluorid sind bevorzugt. Bevorzugt sollte eine Menge von 0,01 - 0,2 Gew.-% Fluor in Form der genannten Verbindungen enthalten sein.Another preferred group of ingredients that may be included in the compositions of the invention are the anti-caries agents. These may be selected, for example, from organic or inorganic fluorides, for. Example of sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Also zinc fluoride, tin (II) fluoride are preferred. An amount of 0.01-0.2% by weight of fluorine should preferably be present in the form of the compounds mentioned.
Erfindungsgemäße Mund- und Zahnpflege- und -reinigungsmittel, die zusätzlich Antikaries-Wirkstoffe, vorzugsweise Fluorverbindung(en), insbesondere Natriumfluorid, Kaliumfluorid, Natriummonofluorphosphat, Zinkfluorid, Zinnfluorid und Natriumfluorosilikat, vorzugsweise in Mengen von 0,01 bis 5 Gew.%, vorzugsweise von 0,1 bis 2,5 Gew.% und insbesondere von 0,2 bis 1,1 Gew.%, jeweils bezogen auf das gesamte Mittel, enthalten, sind erfindungsgemäß bevorzugt.Oral and dental care and cleaning compositions according to the invention, which additionally anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, stannous fluoride and sodium fluorosilicate, preferably in amounts of 0.01 to 5 wt.%, Preferably from 0.1 to 2.5 wt.% And in particular from 0.2 to 1.1 wt.%, Each based on the total agent, are preferred according to the invention.
Die Mund- und Zahnpflege- und reinigungsmittel, insbesondere die Zahnpasten, können z.B. auch Substanzen enthalten, die gegen Zahnstein wirksam sind. Derartige Substanzen können beispielsweise Chelatbildner sein wie z. B. Ethylendiamintetraessigsäure und deren Natriumsalze, Pyrophosphat- Salze wie die wasserlöslichen Dialkali- oder Tetraalkalimetallpyrophosphat- Salze, z. B. Na4P2O7, K4P 2O7, Na2K2P2O 7, Na2H2P2O7 und K 2H2P2O7 oder Polyphosphat-Salze, die z. B. aus wasserlöslichen Alkalimethalltripolyphosphaten wie Natriumtripolyphosphat und Kaliumtripolyphosphat ausgewählt sein können.The oral and dental care and cleaning agents, in particular the toothpastes, for example, may also contain substances that are effective against tartar. Such substances may be, for example, chelating agents such. As ethylenediaminetetraacetic acid and its sodium salts, pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts, z. B. Na 4 P 2 O 7 , K 4 P 2 O 7 , Na 2 K 2 P 2 O 7 , Na 2 H 2 P 2 O 7 and K 2 H 2 P 2 O 7 or polyphosphate salts, the z. B. from water-soluble Alkalimethalltripolyphosphaten as sodium tripolyphosphate and potassium tripolyphosphate can be selected.
Erfindungsgemäß bevorzugte Mund- und Zahnpflege- und -reinigungsmittel sind dadurch gekennzeichnet, daß sie zusätzlich Phosphat(e), vorzugsweise Alkalimetallphosphat(e) und insbesondere Natriumtripolyphosphat, vorzugsweise in Mengen von 1 bis 10 Gew.-%, besonders bevorzugt von 2 bis 8 Gew.-% und insbesondere von 3 bis 7 Gew.-%, jeweils bezogen auf das gesamte Mittel, enthalten.In accordance with the invention preferred oral and dental care and cleaning agents are characterized in that they additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.
Als Konsistenzregler (bzw. Bindemittel) dienen z. B. natürliche und/oder synthetische wasserlösliche Polymere wie Alginate, Carragheenate, Traganth, Stärke und Stärkeether, Celluloseether wie z. B. Carboxymethylcellulose (Na-Salz), Hydroxyethylcellulose, Methylhydroxypropylcellulose, Guar, Akaziengum, Agar-Agar, Xanthan- Gum, Succinoglycan-Gum, Johannisbrotmehl, Pectine, wasserlösliche Carboxyvinylpolymere (z. B. Carbopol®-Typen), Polyvinylalkohol, Polyvinylpyrrolidon, Polyethylenglycole, insbesondere solche mit Molekulargewichten von 1 500-1 000 000.As a consistency regulator (or binder) serve z. As natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such. Carboxymethylcellulose (Na salt), hydroxyethylcellulose, methylhydroxypropylcellulose, guar, acacia, agar, xanthan gum, succinoglycan gum, locust bean gum, pectins, water soluble carboxyvinyl polymers (e.g., Carbopol® types), polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene glycols, in particular those having molecular weights of 1 500-1 000 000.
Weitere Stoffe, die sich zur Viskositätskontrolle eignen, sind z. B. Schichtsilikate wie z. B. Montmorillonit-Tone, kolloidale Verdickungskieselsäuren wie z. B. Aerogel-Kieselsäuren, pyrogene Kieselsäuren oder feinstvermahlene Fällungskieselsäuren. Es können auch viskositätsstabilisierende Zusätze aus der Gruppe der kationischen, zwitterionischen oder ampholytischen stickstoffhaltigen Tenside, der hydroxypropylsubstituierten Hydrocolloide oder der Polyethylenglycol/Polypropylenglycol- Copolymere mit einem mittleren Molgewicht von 1000 bis 5000 oder eine Kombination der genannten Verbindungen in den Zahnpasten verwendet werden.Other substances that are suitable for viscosity control, z. B. phyllosilicates such. As montmorillonite clays, colloidal thickened silicas such. As airgel silicas, fumed silicas or finely ground precipitated silicas. It is also possible to use viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.
Auch oberflächenaktive Substanzen sind in den Zahnpasten zur Unterstützung der Reinigungswirkung und gewünschtenfalls auch zur Entwicklung von Schaum beim Zähnebürsten sowie zur Stabilisierung der Polierkörperdispersion im Träger in einer Menge von 0,1-5 Gew.-% enthalten.Surface-active substances are also present in the toothpastes in support of the cleaning action and, if desired, also for the development of foam in brushing teeth and for stabilizing the polishing body dispersion in the carrier in an amount of 0.1-5% by weight.
Geeignete Tenside sind z. B. lineare Natriumalkylsulfate mit 12-18 C-Atomen in der Alkylgruppe. Diese Stoffe weisen zusätzlich eine enzymhemmende Wirkung auf den bakteriellen Stoffwechsel des Zahnbelags auf. Weitere geeignete Tenside sind Alkalisalze, bevorzugt Natriumsalze von Alkylpolyglycolethersulfat mit 12-16 C-Atomen in der linearen Alkylgruppe und 2-6 Glycolethergruppen im Molekül, von linearem Alkan(C12- C18)-sulfonat, von Sulfobernsteinsäuremonoalkyl(C12-C18)-estern, von sulfatisierten Fettsäuremonoglyceriden, sulfatisierten Fettsäurealkanolamiden, Sulfoessigsäurealkyl(C12-C16 )-estern, Acylsarcosinen, Acyltauriden und Acylisothionaten mit jeweils 8-18 C-Atomen in der Acylgruppe. Auch zwitterionische, ampholytische und nichtionische Tenside sind geeignet, z. B. Oxethylate von Fettsäuremono- und -diglyceriden, von Fettsäure-Sorbitanestern und Alkyl(oligo)-Glucoside.Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque. Other suitable surfactants are alkali metal salts, preferably sodium salts of Alkylpolyglycolethersulfat with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C 12 - C 18) sulfonate, (of C 12 -C 18 Sulfobernsteinsäuremonoalkyl ) esters of sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C 12 -C 16 ) esters, acylsarcosines, acyl taurides and acyl isothionates each having 8-18 C atoms in the acyl group. Also zwitterionic, ampholytic and nonionic surfactants are suitable, for. B. Oxethylates of fatty acid mono- and diglycerides, of fatty acid sorbitan esters and alkyl (oligo) glucosides.
Die Mund- und Zahnpflegemittel, insbesondere die Zahnpasten, können auch die Unempfindlichkeit der Zähne steigernde Substanzen enthalten, beispielsweise Kaliumsalze wie z. B. Kaliumnitrat, Kaliumcitrat, Kaliumchlorid, Kaliumbicarbonat und Kaliumoxalat. Erfindungsgemäß bevorzugte Mund- und Zahnpflege- und -reinigungsmittel sind dadurch gekennzeichnet, daß sie die Unempfindlichkeit der Zähne steigernde Substanzen, vorzugsweise Kaliumsalze, besonders bevorzugt Kaliumnitrat und/oder Kaliumcitrat und/oder Kaliumchlorid und/oder Kaliumbicarbonat und/oder Kaliumoxalat, vorzugsweise in Mengen von 0,5 bis 20 Gew.%, besonders bevorzugt von 1,0 bis 15 Gew.%, weiter bevorzugt von 2,5 bis 10 Gew.-% und insbesondere von 4,0 bis 8,0 Gew.%, jeweils bezogen auf das gesamte Mittel, enthalten.The oral and dental care products, especially the toothpastes, may also contain the insensitivity of the teeth-enhancing substances, such as potassium salts such. As potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate. Oral and dental care and cleaning agents which are preferred according to the invention are characterized in that they comprise the insensitivity of the teeth-increasing substances, preferably potassium salts, particularly preferably potassium nitrate and / or potassium citrate and / or potassium chloride and / or potassium bicarbonate and / or potassium oxalate, preferably in amounts of From 0.5 to 20% by weight, more preferably from 1.0 to 15 wt.%, More preferably from 2.5 to 10 wt .-% and in particular from 4.0 to 8.0 wt.%, Each based on the total agent included.
Die erfindungsgemäßen Mittel, insbesondere die Zahnpasten, können auch zusätzlich weitere wundheilende und entzündungshemmende Stoffe, z. B. Wirkstoffe gegen Zahnfleischentzündungen, enthalten. Derartige Stoffe können z. B. ausgewählt sein aus Allantoin, Azulen, Kamillenextrakten, Tocopherol, Panthenol, Bisabolol, Salbeiextrakten.The compositions according to the invention, in particular the toothpastes, can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included. Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.
Als nicht-kationische, bakterizide Komponente eignen sich z.B. Phenole, Resorcine, Bisphenole, Salicylanilide und deren halogenierte Derivate, halogenierte Carbanilide und p-Hydroxybenzoesäureester. Besonders bevorzugte antimikrobielle Komponenten sind halogenierte Diphenylether, z.B. 2,4-Dichlor-2`-hydroxydiphenylether, 4,4'-Dichlor-2'-hydroxydiphenylether, 2,4,4'-Tribrom-2'-hydroxydiphenylether und 2,4,4'-Trichlor-2'-hydroxydiphenylether (Triclosan). Sie werden bevorzugt in Mengen von 0,01 - 1 Gew.-% in die erfindungsgemäßen Zahnpflegemittel eingesetzt. Besonders bevorzugt wird Triclosan in einer Menge von 0,01 - 0,3 Gew.-% eingesetzt.As a non-cationic, bactericidal component, e.g. Phenols, resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters. Particularly preferred antimicrobial components are halogenated diphenyl ethers, e.g. 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether and 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan). They are preferably used in amounts of from 0.01 to 1% by weight in the dentifrices according to the invention. Triclosan is particularly preferably used in an amount of 0.01-0.3% by weight.
D-Panthenol D - (+) - 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-butyramid zeigt eine der Pantothensäure entsprechende biologische Aktivität. Die Pantothensäure (R - (+) - N - (2,4-Dihydroxy-3,3-dimethylbutyryl-ß-alanin) ist eine Vorstufe in der Biosynthese des Coenzyms A und wird zum Vitamin-B-Komplex (B3) gezählt. Diese Stoffe sind dafür bekannt, daß sie die Wundheilung fördern und eine günstige Wirkung auf die Haut haben. Sie sind daher auch gelegentlich in Zahnpasten beschrieben worden. Die erfindungsgemäßen Zahnpflegemittel enthalten bevorzugt 0,05 - 5 Gew.-% Panthenol oder ein Salz der Pantothensäure.D-panthenol D - (+) - 2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethyl-butyramide exhibits a biological activity corresponding to pantothenic acid. The pantothenic acid (R - (+) - N - (2,4-dihydroxy-3,3-dimethylbutyryl-β-alanine) is a precursor in the biosynthesis of coenzyme A and is counted to the vitamin B complex (B3). These substances are known to promote wound healing and have a beneficial effect on the skin and have therefore been occasionally described in toothpastes The dentifrices of the invention preferably contain 0.05-5% by weight of panthenol or a salt of pantothenic acid ,
Retinol (3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol ist der internationale Freiname für Vitamin A1. Anstelle des Retinols kann auch eines seiner Derivate mit ähnlicher biologischer Wirkung, z.B. ein Ester oder die Retinoesäure (Tretinoin), eines ihrer Salze oder ihre Ester verwendet werden. Bevorzugt wird ein Retinol-Ester, insbesondere ein Fettsäureester einer Fettsäure mit 12 - 22 C-Atomen verwendet. Besonders bevorzugt ist Retinol-Palmitat geeignet. Bei Verwendung eines Retinol-Esters, z.B. Retinol-Palmitat mit einer Aktivität von 1,7 106 I.E. pro g ist eine Menge von 0,001 bis 0,1 Gew.-% bevorzugt. Bei Verwendung anderer Retinol-Derivate empfiehlt sich eine Einsatzmenge, die einer Konzentration von 103 bis 106 I.E. (Internationale Einheiten) pro 100 g entspricht. Bevorzugte Zahnpflegemittel gemäß der vorliegenden Erfindung enthalten neben Poliermitteln, Fluorverbindungen, Feuchthaltemitteln und Bindemitteln bevorzugt
0,01 - 1 Gew.-% eines halogenierten Diphenylethers
0,05 - 5 Gew.-% Panthenol oder ein Salz der Pantothensäure und
0,01 - 0,1 Gew.-% eines Retinol-Esters, bevorzugt Retinol-Palmitat.Retinol (3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexenyl) -2,4,6,8-nonatetraen-1-ol is the international common name for vitamin A1, but may also be used instead of retinol one of its derivatives having similar biological activity, for example an ester or the retinoic acid (tretinoin), one of its salts or its esters is preferably used, preferably a retinol ester, in particular a fatty acid ester of a fatty acid having 12-22 carbon atoms if retinol palmitate is used, an amount of 0.001 to 0.1% by weight is preferred when using a retinol ester, for example retinol palmitate with an activity of 1.710 6 IU per g, when using other retinol derivatives It is advisable to use an amount corresponding to a concentration of 10 3 to 10 6 IU (international units) per 100 g Preferred dentifrices according to the present invention comprise, in addition to polishing agents, fluorine compounds, humectants and binders
0.01 - 1 wt .-% of a halogenated diphenyl ether
0.05 - 5 wt .-% panthenol or a salt of pantothenic acid and
0.01-0.1% by weight of a retinol ester, preferably retinol palmitate.
Die erfindungsgemäßen Mittel, insbesondere die Zahnpasten, können auch Substanzen zur Erhöhung des mineralisierenden Potentials enthalten, beispielsweise calciumhaltige Substanzen wie z. B. Calciumchlorid, Calciumacetat und Dicalciumphosphat-Dihydrat. Die Konzentration der calciumhaltigen Substanz hängt von der Löslichkeit der Substanz und dem Zusammenwirken mit anderen in dem Mund- und Zahnpflegemittel enthaltenen Substanzen ab.The agents according to the invention, in particular the toothpastes, may also contain substances for increasing the mineralizing potential, for example calcium-containing substances such as, for example, Calcium chloride, calcium acetate and dicalcium phosphate dihydrate. The concentration of the calcium-containing substance depends on the solubility of the substance and the interaction with other substances contained in the oral and dental care products.
Neben den genannten obligatorischen Komponenten können die erfindungsgemäßen Zahnpflegemittel weitere, an sich bekannte Hilfs- und Zusatzstoffe enthalten. Dabei ist ein Zusatzstoff, der als Zahnpastenkomponente seit langem bekannt ist, in den erfindungsgemäßen Zahnpflegemitteln besonders wirksam: Calcium-glycerophosphat, das Calcium-Salz der Glycerin-1-phosphorsäure oder der Glycerin-2-phosphorsäure oder der zur Glycerin-1-phosphorsäure enantiomeren Glycerin-3-phosphorsäure - oder eines Gemisches dieser Säuren. Die Verbindung hat in Zahnpflegemitteln eine remineralisierende Wirkung, da sie sowohl Calcium- als auch Phosphationen liefert. In den erfindungsgemäßen Zahnpflegemitteln wird Calciumglycerophosphat bevorzugt in Mengen von 0,01 - 1 Gew.-% eingesetzt. Insgesamt können die erfindungsgemäßen Zahnreinigungsmittel übliche Hilfsmittel und Zusatzstoffe in Mengen bis zu 10 Gew.-% enthalten.In addition to the compulsory components mentioned, the dentifrices according to the invention may contain further adjuvants and additives known per se. An additive which has been known for a long time as a toothpaste component is particularly effective in the dentifrices according to the invention: calcium glycerophosphate, the calcium salt of glycerol-1-phosphoric acid or glycerol-2-phosphoric acid or the glycerol-1-phosphoric acid enantiomer Glycerol-3-phosphoric acid - or a mixture of these acids. The compound has a remineralizing effect in dentifrices as it provides both calcium and phosphate ions. In the dentifrices according to the invention calcium glycerophosphate is preferably used in amounts of 0.01 to 1 wt .-%. Overall, the dentifrices according to the invention may contain customary auxiliaries and additives in amounts of up to 10% by weight.
Die erfindungsgemäßen Zahnpflegemittel können z.B. durch Zusatz von Aromaölen und Süßungsmitteln in ihren organoleptischen Eigenschaften verbessert werden.The dentifrices according to the invention may e.g. be improved by the addition of aromatic oils and sweeteners in their organoleptic properties.
Als Aromaöle können alle die für Mund- und Zahnpflegemittel üblichen natürlichen und synthetischen Aromen eingesetzt werden. Natürliche Aromen können sowohl in Form der aus Drogen isolierten natürlichen ätherischen Öle als auch der daraus isolierten Einzelkomponenten enthalten sein.As aroma oils, all the natural and synthetic flavors customary for oral and dental care products can be used. Natural flavors can be contained both in the form of natural essential oils isolated from drugs and the individual components isolated therefrom.
Geeignete Aromen sind z.B. Pfefferminzöl, Krauseminzöl, Eukalyptusöl, Anisöl, Fenchelöl, Kümmelöl, Menthylacetat, Zimtaldehyd, Anethol, Vanillin, Thymol sowie Mischungen dieser Komponenten.Suitable flavors are e.g. Peppermint oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and mixtures of these components.
Geeignete Süßungsmittel sind z.B. Saccharin-Natrium, Natrium-Cyclamat, Sucrose, Lactose, Meltose, Fructose.Suitable sweeteners are e.g. Saccharin sodium, sodium cyclamate, sucrose, lactose, meltose, fructose.
Weitere übliche Hilfs- und Zusatzstoffe für Zahnpasten sind
- Oberflächenaktive Stoffe, bevorzugt anionische, zwitterionische, amphotere, nicht- ionische Tenside oder eine Kombination mehrerer verschiedener Tenside
- Lösungsmittel und Lösungsvermittler, z.B. niedere einwertige oder mehrwertige Alkohole oder Ether, z.B. Ethanol, 1,2-Propylenglycol, Diethylenglycol oder Butyldi- glycol
- Pigmente, wie z.B. Titandioxid
- Farbstoffe
- Puffersubstanzen, z.B. primäre, sekundäre oder tertiäre Alkaliphosphate oder Citronensäure-/Na-Citrat
- weitere wundheilende oder entzündungshemmende Stoffe, z.B. Allantoin, Harnstoff, Azulen, Kamillewirkstoffe, Acetylsalicylsäurederivate oder Rhodanid
- weitere Vitamine wie z.B. Ascorbinsäure, Biotin, Tocopherol oder Rutin
- Mineralsalze wie z.B. Mangan-, Zink- oder Magnesiumsalze.
Further customary auxiliaries and additives for toothpastes are - Surface-active substances, preferably anionic, zwitterionic, amphoteric, nonionic surfactants or a combination of several different surfactants
- Solvents and solubilizers, for example lower monohydric or polyhydric alcohols or ethers, for example ethanol, 1,2-propylene glycol, diethylene glycol or butyldichi glycol
- Pigments, such as titanium dioxide
- dyes
- Buffer substances, for example primary, secondary or tertiary alkali metal phosphates or citric acid / Na citrate
- other wound-healing or anti-inflammatory substances, for example allantoin, urea, azulene, chamomile active ingredients, acetylsalicylic acid derivatives or rhodanide
- other vitamins such as ascorbic acid, biotin, tocopherol or rutin
- Mineral salts such as manganese, zinc or magnesium salts.
Eine weitere wichtige Gruppe von Inhaltstoffen, die in den erfindungsgemäßen Mitteln enthalten sein kann, sind die sogenannten bioaktiven Gläser.Another important group of ingredients that may be included in the compositions of the invention are the so-called bioactive glasses.
Der Begriff "bioaktive Gläser" umfaßt im Rahmen der vorliegenden Anmeldung Gläser, welche biologisch wirksam und/oder biologisch aktiv sind. Die biologische Wirksamkeit eines Glases kann sich beispielsweise in dessen antimikrobiellen Eigenschaften zeigen, biologisch aktives Glas unterscheidet sich von herkömmlichen Kalk-Natrium-Silicat-Gläsern dadurch, daß es lebendes Gewebe bindet. Biologisch aktives Glas bezeichnet dabei beispielsweise ein Glas, das eine feste Bindung mit Körpergewebe eingeht, wobei eine Hydroxyl-Apatitschicht ausgebildet wird. Unter bioaktivem Glas wird auch ein Glas verstanden, das antimikrobielle und/oder entzündungshemmende Wirkung zeigt. Die Glaspulver zeigen gegenüber Bakterien, Pilzen sowie Viren eine biozide bzw. eine biostatische Wirkung; sind im Kontakt mit dem Menschen hautverträglich, toxikologisch unbedenklich und insbesondere auch zum Verzehr geeignet.The term "bioactive glasses" in the context of the present application comprises glasses which are biologically active and / or biologically active. For example, the biological effectiveness of a glass can be demonstrated in its antimicrobial properties, biologically active glass differs from conventional lime-sodium-silicate glasses in that it binds living tissue. Biologically active glass, for example, refers to a glass which forms a firm bond with body tissue, forming a hydroxylapatite layer. Bioactive glass is also understood to mean a glass which exhibits antimicrobial and / or anti-inflammatory action. The glass powders show a biocidal or biostatic effect against bacteria, fungi and viruses; are in contact with humans skin-friendly, toxicologically safe and especially suitable for consumption.
Erfindungsgemäß besonders bevorzugte Mund- und Zahnpflege- und -reinigungsmittel sind dadurch gekennzeichnet, daß sie 0,2 bis 20 Gew.-%, vorzugsweise 0,4 bis 14 Gew.-%, besonders bevorzugt 0,5 bis 3 Gew.-% und insbesondere 0,6 bis 2 Gew.-% mindestens eines bioaktiven Glases enthalten.Oral and dental care and cleaning agents which are particularly preferred according to the invention are characterized in that they contain from 0.2 to 20% by weight, preferably from 0.4 to 14% by weight, more preferably from 0.5 to 3% by weight, and in particular 0.6 to 2 wt .-% of at least one bioactive glass.
Die erfindungsgemäßen Mund- und Zahnpflege- und -reinigungsmittel dieser Ausführungsform enthalten bioaktives Glas oder Glaspulver oder Glaskeramikpulver oder Kompositmaterialien, welche ein solches bioaktives Glas umfassen. Unter Glaspulvern werden im Rahmen der vorliegenden Anmeldung auch Granulate und Glaskügelchen verstanden.The oral and dental care and cleaning compositions of this embodiment contain bioactive glass or glass powder or glass ceramic powder or composite materials comprising such a bioactive glass. For the purposes of the present application, glass powders are also understood as meaning granules and glass beads.
Aufgrund der Anforderungen an die toxikologische Unbedenklichkeit des Glases sowie deren Eignung zum Verzehr soll das Glaspulver besonders rein sein. Die Belastung durch Schwermetalle ist vorzugsweise gering. So beträgt die Maximalkonzentration im Bereich der kosmetischen Formulierungen vorzugsweise für Pb < 20 ppm, Cd < 5 ppm, As < 5 ppm, Sb < 10 ppm, Hg < 1 ppm, Ni < 10 ppm.Due to the requirements for the toxicological safety of the glass and its suitability for consumption, the glass powder should be particularly pure. The burden of heavy metals is preferably low. Thus, the maximum concentration in the range of cosmetic formulations is preferably for Pb <20 ppm, Cd <5 ppm, As <5 ppm, Sb <10 ppm, Hg <1 ppm, Ni <10 ppm.
Das unkeramisierte Ausgangsglas, das direkt in den bevorzugten erfindungsgemäßen Zusammensetzungen enthalten oder gegebenenfalls für die Herstellung einer erfindungsgemäß einsetzbaren Glaskeramik verwandt wird, enthält SiO2 als Netzwerkbildner, vorzugsweise zwischen 35-80 Gew.-%. Bei niedrigeren Konzentrationen nimmt die spontane Kristallisationsneigung stark zu und die chemische Beständigkeit stark ab. Bei höheren SiO2-Werten kann die Kristallisationsstabilität abnehmen, und die Verarbeitungstemperatur wird deutlich erhöht, so daß sich die Heißformgebungseigenschaften verschlechtern. Na2O wird als Flußmittel beim Schmelzen des Glases eingesetzt. Bei Konzentrationen kleiner 5% wird das Schmelzverhalten negativ beeinflußt. Natrium ist Bestandteil der sich bei der Keramisierung bildenden Phasen und muß, sofern hohe kristalline Phasenanteile durch die Keramisierung eingestellt werden sollen, in entsprechend hohen Konzentrationen im Glas enthalten sein. K2O wirkt als Flußmittel beim Schmelzen des Glases. Außerdem wird Kalium in wässrigen Systemen abgegeben. Liegen hohe Kaliumkonzentrationen im Glas vor, werden kaliumhaltige Phasen wie Kalzium-Silicaten ebenfalls ausgeschieden. Über den P2O5-Gehalt kann bei silikatischen Gläsern, Glaskeramiken oder Kompositen die chemische Beständigkeit des Glases und damit die lonenabgabe in wässrigen Medien eingestellt werden. Bei Phospahtgläsern ist P2O5 Netzwerkbilder. Der P2O5-Gehalt liegt vorzugsweise zwischen 0 und 80 Gew.-%. Um die Schmelzbarkeit zu verbessern, kann das Glas bis zu 25 Gew.- % B2O3 enthalten. Al2O3 wird genutzt, um die chemische Beständigkeit des Glases einzustellen.The unfused starting glass, which is contained directly in the preferred compositions according to the invention or is optionally used for the production of a glass ceramic which can be used according to the invention, contains SiO 2 as a network former, preferably between 35-80% by weight. At lower concentrations, the spontaneous tendency to crystallize increases greatly and the chemical resistance decreases sharply. At higher SiO 2 values, the crystallization stability may decrease and the processing temperature is significantly increased, so that the hot-forming properties deteriorate. Na 2 O is used as a flux when melting the glass. At concentrations of less than 5%, the melting behavior is adversely affected. Sodium is a constituent of the phases which form during the ceramization and, if high crystalline phase fractions are to be adjusted by the ceramization, must be present in the glass in correspondingly high concentrations. K 2 O acts as a flux when melting the glass. In addition, potassium is released in aqueous systems. If high potassium concentrations are present in the glass, potassium-containing phases such as calcium silicates are also eliminated. The P 2 O 5 content of silicate glasses, glass ceramics or composites can be used to adjust the chemical resistance of the glass and thus the release of ions in aqueous media. For Phospaht glasses, P 2 O 5 is network images. The P 2 O 5 content is preferably between 0 and 80 wt .-%. In order to improve the meltability, the glass may contain up to 25% by weight of B 2 O 3 . Al 2 O 3 is used to adjust the chemical resistance of the glass.
Zur Verstärkung der antimikrobiellen, insbesondere der antibakteriellen Eigenschaften der Glaskeramik können antimikrobiell wirkende Ionen wie z. B. Ag, Au, l, Ce, Cu, Zn in Konzentrationen kleiner 5 Gew.-% enthalten sein.To enhance the antimicrobial, in particular the antibacterial properties of the glass-ceramic antimicrobial acting ions such. B. Ag, Au, l, Ce, Cu, Zn in concentrations less than 5 wt .-% may be included.
Farbgebende Ionen wie z. B. Mn, Cu, Fe, Cr, Co, V, können einzeln oder kombiniert, vorzugsweise in einer Gesamtkonzentration kleiner 1 Gew.-%, enthalten sein.Coloring ions such. As Mn, Cu, Fe, Cr, Co, V, may be contained individually or in combination, preferably in a total concentration less than 1 wt .-%.
Üblicherweise wird das Glas bzw. die Glaskeramik in Pulverform eingesetzt. Die Keramisierung kann entweder mit einem Glasblock bzw. Glasribbons erfolgen oder aber mit Glaspulver. Nach der Keramisierung müssen die Glaskeramikblöcke oder Ribbons zu Pulver gemahlen werden. Wurde das Pulver keramisiert, muß gegebenenfalls auch erneut gemahlen werden, um Agglomerate, die während des Keramisierungsschrittes entständen sind, zu entfernen. Die Mahlungen können sowohl trocken als auch in wässrigen oder nicht wässrigen Mahlmedien durchgeführt werden. Üblicherweise liegen die Partikelgrößen kleiner 500 µm. Als zweckmäßig haben sich Partikelgrößen < 100 µm bzw. < 20 µm erwiesen. Besonders geeignet sind Partikelgrößen < 10 µm sowie kleiner 5 µm sowie kleiner 2 µm, siehe weiter unten.Usually, the glass or the glass ceramic is used in powder form. The ceramization can be done either with a glass block or Glasribbons or with glass powder. After ceramization, the glass ceramic blocks or ribbons must be ground to powder. If the powder has been ceramified, it may also be necessary to re-mill to remove agglomerates formed during the ceramification step. The grinding can be carried out both dry and in aqueous or non-aqueous grinding media. Usually, the particle sizes are less than 500 microns. As appropriate have Particle sizes <100 microns and <20 microns proven. Particularly suitable are particle sizes <10 microns and less than 5 microns and less than 2 microns, see below.
Die in den bevorzugten erfindungsgemäßen Zusammensetzungen enthaltenen bioaktiven Gläser bzw. Glaspulver oder Glaskeramikpulver oder Komposit-Zusammensetzungen umfassen Gläser, die bevorzugt nachfolgende Komponenten umfassen: SiO2: 35-80 Gew.-%, Na2O: 0-35 Gew.- %, P2O5: 0-80 Gew.-%, MgO: 0-5 Gew.-%, Ag2O: 0-0,5 Gew.-%, AgJ: 0-0,5 Gew.- %, NaJ: 0-5 Gew.-%, TiO2: 0-5 Gew.-%, K2O: 0-35 Gew.-%, ZnO: 0-10 Gew.-%, Al2O3: 0-25 Gew.-% undB2O3: 0-25 Gew.-% .The bioactive glasses or glass powder or glass ceramic powder or composite compositions contained in the preferred compositions according to the invention comprise glasses which preferably comprise the following components: SiO 2 : 35-80% by weight, Na 2 O: 0-35% by weight, P 2 O 5 : 0-80 wt%, MgO: 0-5 wt%, Ag 2 O: 0-0.5 wt%, AgJ: 0-0.5 wt%, NaJ : 0-5 wt%, TiO 2 : 0-5 wt%, K 2 O: 0-35 wt%, ZnO: 0-10 wt%, Al 2 O 3 : 0-25 Wt% and B 2 O 3 : 0-25 wt%.
Weiterhin können dem Grundglas gemäß obiger Zusammensetzung zur Erzielung weiterer Effekte wie beispielsweise Farbigkeit oder UV-Filterung Ionen wie Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J einzeln oder in Summe bis zu 10 Gew.-% zugegeben werden. Eine weiter Glaszusammensetzung kann wie folgt sein: SiO 2: 35-80 Gew.-%, Na2O: 0-35 Gew.-%, P2O5: 0-80 Gew.-%, MgO: 0-5 Gew.- %, Ag2O: 0-0,5 Gew.-%, AgJ: 0-0,5 Gew.-%, NaJ: 0-5 Gew.-%, Ti02: 0-5 Gew.-%, K 2O: 0-35 Gew.-%, ZnO: 0-10 Gew.-%, Al2 O3: 0-25 Gew.-%, B2O3: 0- 25 Gew.-%, SnO: 0-5 Gew.-%, CeO2: 0-3 Gew.- % und Au: 0,001-0,1 Gew.-%.Furthermore, the base glass according to the above composition to achieve further effects such as color or UV filtering ions such as Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J individually or in total to be added to 10 wt .-%. A further glass composition may be as follows: SiO 2 : 35-80 wt%, Na 2 O: 0-35 wt%, P 2 O 5 : 0-80 wt%, MgO: 0-5 wt %, Ag 2 O: 0-0.5 wt%, AgJ: 0-0.5 wt%, NaJ: 0-5 wt%, Ti0 2 : 0-5 wt% , K 2 O: 0-35 wt .-%, ZnO: 0-10 wt .-%, Al 2 O 3 : 0-25 wt .-%, B 2 O 3 : 0- 25 wt .-%, SnO : 0-5 wt%, CeO 2 : 0-3 wt% and Au: 0.001-0.1 wt%.
Besonders bevorzugte erfindungsgemäße Mund- und Zahnpflege- und -reinigungsmittel sind dadurch gekennzeichnet, daß das bioaktive Glas - bezogen auf sein Gewicht - folgende Zusammensetzung aufweist:
SiO2 35 bis 60 Gew.-%, vorzugsweise 40 bis 60 Gew.-%,
Na2O 0 bis 35 Gew.-%, vorzugsweise 5 bis 30 Gew.-%,
K2O 0 bis 35 Gew.-%, vorzugsweise 0 bis 20 Gew.-%,
P2O5 0 bis 10 Gew.-%, vorzugsweise 2 bis 10 Gew.-%,
MgO 0 bis 10 Gew.-%, vorzugsweise 0 bis 5 Gew.-%,
CaO 0 bis 35 Gew.-%, vorzugsweise 5 bis 30 Gew.-%,
Al2O3 0 bis 25 Gew.-%, vorzugsweise 0 bis 5 Gew.-%,
B2O3 0 bis 25 Gew.-%, vorzugsweise 0 bis 5 Gew.-%,
TiO2 0 bis 10 Gew.-%, vorzugsweise 0,1 bis 5 Gew.-%.
Wie bereits weiter oben erwähnt, wird das bioaktive Glas vorzugsweise in partikulärer Form eingesetzt. Hier sind besonders bevorzugte erfindungsgemäße Mund- und Zahnpflege- und - reinigungsmittel dadurch gekennzeichnet, daß das antimikrobielle Glas Teilchengrößen < 10 µm, vorzugsweise von 0,5 bis 4 µm, besonders bevorzugt von 1 bis 2 µm, aufweist.Particularly preferred oral and dental care and cleaning agents according to the invention are characterized in that the bioactive glass - based on its weight - has the following composition: SiO 2 From 35 to 60% by weight, preferably 40 to 60% by weight,
Na 2 O 0 to 35% by weight, preferably From 5 to 30% by weight,
K 2 O 0 to 35% by weight, preferably 0 to 20% by weight,
P 2 O 5 0 to 10% by weight, preferably From 2 to 10% by weight,
MgO 0 to 10% by weight, preferably 0 to 5% by weight,
CaO 0 to 35% by weight, preferably From 5 to 30% by weight,
Al 2 O 3 0 to 25% by weight, preferably 0 to 5% by weight,
B 2 O 3 0 to 25% by weight, preferably 0 to 5% by weight,
TiO 2 0 to 10% by weight, preferably 0.1 to 5 wt .-%.
As already mentioned above, the bioactive glass is preferably used in particulate form. Here are particularly preferred oral and dental care and - cleaning agent according to the invention characterized in that the antimicrobial glass particle sizes <10 .mu.m, preferably from 0.5 to 4 .mu.m, more preferably from 1 to 2 microns.
Die nachfolgenden Beopsiele dienen der Veranschaulichung der vorliegenden Erfindung:The following examples serve to illustrate the present invention:
Beispiele:Examples:
Es wurden Zahnpasten folgender Zusammensetzung hergestellt:
E1 E2 E3 E4 E5
Sorbit (70 % DAB) 60 62,5 65 67,5 70,0
Ethanol (96%) - - - - 2,0
Fällungskieselsäure : Sident 8 10,0 10,0 10,0 10,0 12,0
Fällungskieselsäure : Sident 22S 8,5 8,5 8,5 8,5 -
Poliertonerde P10 feinst - 1,0 - - -
Dinatriumphosphat, wasserfrei 0,1 0,1 0,1 0,1 0,1
Trinatriumphosphat, wasserfrei 0,2 0,2 0,2 0,2 -
MgSO4.7H2O
Na-Monofluorophosphat Na2PO3F - - 1,0 1,0 1,0
Natriumfluorid 0,32 0,32 - - -
Polyethylenglycol (MG : 1500) 1,5 1,5 1,5 1,5 1,5
Titandioxid 0,5 0,5 0,5 0,5 -
Na-Laurylsulfat 1,5 1,5 1,5 1,5 1,5
Saccharin-Na 0,1 0,1 0,1 0,1 0,1
Xanthan 0,4 0,4 0,4 0,4 0,4
Aroma 1,2 1,2 1,2 1,2 1,2
Jambu Oleoresin (30 % Spilanthol) 0,1 0,02 - - 0,05
Ginger Oleoresin - - 0,03 - -
N-ethyl-p-menthan-3-carboxamid - - - 0,1 -
Wasser ad 100 ad 100 ad 100 ad 100 ad 100
Toothpastes of the following composition were prepared: E1 E2 E3 E4 E5
Sorbitol (70% DAB) 60 62.5 65 67.5 70.0
Ethanol (96%) - - - - 2.0
Precipitated silica: sident 8 10.0 10.0 10.0 10.0 12.0
Precipitated silica: Sident 22S 8.5 8.5 8.5 8.5 -
Poliertonerde P10 finest - 1.0 - - -
Disodium phosphate, anhydrous 0.1 0.1 0.1 0.1 0.1
Trisodium phosphate, anhydrous 0.2 0.2 0.2 0.2 -
MgSO4.7H2O
Na monofluorophosphate Na 2 PO 3 F - - 1.0 1.0 1.0
sodium fluoride 0.32 0.32 - - -
Polyethylene glycol (MW: 1500) 1.5 1.5 1.5 1.5 1.5
Titanium dioxide 0.5 0.5 0.5 0.5 -
Na lauryl sulfate 1.5 1.5 1.5 1.5 1.5
Saccharin-Na 0.1 0.1 0.1 0.1 0.1
xanthan 0.4 0.4 0.4 0.4 0.4
Aroma 1.2 1.2 1.2 1.2 1.2
Jambu oleoresin (30% spilanthol) 0.1 0.02 - - 0.05
Ginger Oleoresin - - 0.03 - -
N-ethyl-p-menthane-3-carboxamide - - - 0.1 -
water ad 100 ad 100 ad 100 ad 100 ad 100
Die erfindungsgemäßen Zusammensetzungen wurden von einem Verbraucherpanel aus 20 Verbrauchern als "angenehm prickelnd" bzw. "von warmer Schärfe" beschrieben. Ansonsten analog zusammengesetzte Zusammensetzungen, die weniger als 40 Gew.-% Sorbit (entsprechend weniger als 57,14 Gew.-% 70%iges Sorbitol) enthielten, wurden als sensorisch unbefriedigender bewertet.The compositions according to the invention were described by a consumer panel of 20 consumers as "pleasantly tingling" or "of warm sharpness". Otherwise, analogous compositions containing less than 40% by weight of sorbitol (corresponding to less than 57.14% by weight of 70% sorbitol) were evaluated as being less sensorially sensitive.