US2386252A - Antiseptic composition - Google Patents

Description

Patented Oct. 9, 1945 mv'rrsnr'rrc coMrosrrroN Majer Mendelsohn, New York, N. Y.

N Drawing. Application February 21, 1942,

Serial No. 431,896-

8 Claims.

of the skin may accompany such an application.'

It is an object of theinvention to provide a medium for use in effecting the antiseptic action of iodin while eliminating such undesirable fac' tors as discoloration of markedly appreciable areas, heating, blistering or burning of the skin, and especially of areas not actually requiring the antiseptic action of the iodin, and so to limitthe action of the medium that it is efiective and active only upon those specific areas which are infected,

no injurious effect upon the skin, ti: inches of the body at which bacte is not present and to which the medi It is an object of the invention medium for effecting antiseptic s character indicated, wherein the n plicable for treatment, as, for insi pregnation, of bandages, tooth brusl appliances or devices, used in the or of prevention or treatment of disc such bandages, appliances or devices sterile, and to insure that such bar ances or devices thereafter shall co substantially under all conditions.

It is an objectof the invention medium for effecting antiseptic a character indicated, wherein the m plicable for treatment, as, for inst pregnation, of bandages, tooth brusl and remains dormant wherever an infecting agent is not active. v

- It is an object of the invention to provide a medium for effecting antiseptic action wherein such medium will, only when utilized and brought into chemical relation to a bacteria-infected region 'of the skin or body, and not until then, release iodin substantially in the nascent state, whereupon antiseptic action may occur instantaneously, for all practical purposes.

- as hot water or the like;

appliances'or" devices, to insure the ages, appliances or devices thereaft tinue sterile substantially under a but wherein the sterility-controllin: bonded to bandage, device or applia not removed from its combination b Other objects of this'invention wi hereinafter, or will be apparent fron tion wherein certain embodiments It is an object of the invention to provide a medium, for effecting antiseptic action of the type hereinbefore set forth, which normally is colorless, and will not stain ordinary fabrics.

' It is an object of the invention to provide a medium for efiecting antiseptic action wherein.

the medium normally remains dormant until it is in contact with or is acted upon or affected by the pH, or. hydrogen ion concentration, of bacteria, whereupon a controlled reaction of such medium will occur, with instantaneous liberation of iodin in amounts determined by the amounts of bacteria present, and, therefore, the resultant pH or hydrogen ion concentration, with consequent destruction of the bacteria and disappearance of the hydrogen ion concentration" set up by such bacteria.

It is an objector the invention to provide a medium for effecting antiseptic action by pre--' senting iodin substantially instantaneously upon being Jo'rought into contact with bacteria infecting an area of the body, where the medium nor-' maliy is colorless and non-reactive, and capable of continuing in that condition, and will produce out the invention are exemplified.

The invention, however, is not in restricted to any particular compo: particular proportion, or any partic tion of any such composition or p any articular process of preparatio of operation, or use, or any of v2 thereof, even where spiecifically desc as the same may be modified in var lars or,may be-applied in many val without departing from the spirit the claimed invention, of which the embodiments, herein described, are i to be illustrative, and only fortthe pm plying with the requirements of the disclosure of an operative embodin: to demonstrate all the various mm which the invention might be embo It has been discovered that certai; which include iodin as a combined el brought together into solution, re: fected areas of the body to liberal means of certain controls, the libel iodin may be governed so that it or the time the solution has actually to and is intimate contact with the a:

iodin mixture." When the term, iodin mixture," is used, reference is intended only to the In just mentioned until the'soluthe pH, or hydrogen ion con- :ed by a bacterium, or, in the by the hydrogen ion conceninfected by bacteria. A chemrensue when the solution and .cing the pH or hydrogen ionide, and that chemical reaction ion. of Just sufficient iodin to ria, and, thereby, their hydroeffect. When this stage in ched, no further iodin is libera free or nascent iodin hasbeen become combined by the steri a solution remains substantially e to combat any further baclnd that by bringing a soluble leiodate in certain proportions ilizing the relationship of these 0 each other, and fixing the ingredients in this relationship, and not to any degree of concentration in solution.

It has'been determined ,that certain ingredients must be associated with the iodin mixture to go intosolution at the same .time as the ingredients of the iodin mixture in. order to stabihas the reaction, and to assure that iodin shall not be liberated unless the solution containing the iodin mixture be in contact with an area to be made antiseptic, and then only if there be present in that area bacteria which would destroy the sterility or aseptic condition of the area. The soluble salt of orthophosphoric acid has been found effective for this purpose, and, especially, disodium orthophosphate. It was found that a desiredcontrol for the reaction of such a solution resulted when a relationship'existed in which the disodium orthophosphate could be varied icetween 3 and 4 parts while the amount of the iodin mixture could be varied between 3.7 to 4.2 parts. The application of these variables can be determined from experience'by the one who makes up the solution, or the powdered material with which the solution will be prepared. For

- instance, the proportion of the stabilizing ingredientto the iodin mixture will be higher during the warmer seasons of the year because of the nor'mallyhigher acidic condition of the skin of the body arising from the higher rate of perspiration. 1

Another ingredient capable of functioning to 4 stabilize the reaction is a soluble acid carbonate.

lide and iodate to the stabilize solution will'be and remain le,. and colorless until affected concentration. Such solution,

1 infected area, as, for instance,

' lesion, is found to be affected i and instantaneous reaction :lin in quantities automatically degree of infection, or, in other iber of .bacteria present and to A the sterilizing medium; The is nascent,,and in condition, iberation, instantaneously, and to react upon and destroy the used its liberation. The reac- I n, on'the other hand, is foll1 combination of the iodin, .onger exists in the free state, substantial degree, can effect abrics or the like with which owhich the solution has been" into contact. pplication of the'invention, the droiodic acid and of iodic acid, dide and sodium iodate, were ;ive and stabilized reaction was nxiodate and iodide were pres-- .ship'oi one molecule of iodate of iodide. A mixture of the its, in theseproportions, could the other hand, the medium in the form of a solution in iodide would be present in the relationship. In either case, :nce herein, this relationship a, that is, of one molecule of cules of iodide, will be termed,

In this particular instance. sodium bicarbonate was found to be peculiarly effective. The'sodium bicarbonate was found to be effective between the limits of 0.4 to 0.666 part to between 3.7 to 4.2 parts of the. iodin mixture. Either the disodium 'orthophosphate or the sodium bicarbonate, or both, will function to slow down the reaction of the ingredients of the iodin mixture whereby the nascent iodin-is liberated. Increase of the disodium orthophosphate or the sodium bicarbonate in ratio to the iodin mixture will increase the function in slowing down the liberation of iodin; on the other. hand, reduction of the disodium orthophosphate or the sodium bicarbonate in ratio to the iodin mixture will increase the speed of separationof iodin when a proper pH or hydrogen ion concentration is met.

In treating certain conditions where bleeding is present as a factor, as, for instance, a cut at the outside surface of the body, coagulation of the blood flowing from the wound may follow rapidly. 'andmay close the opening through which "the antiseptic medium here considered is to opcrate, presenting a consequentand effectual barrier against the action of the iodin mixture in destroying bacteria thus enclosed within the wound. Therefore, it has been'found desirable to slow up the process of coagulation. For this purpose, there may beadded to the dry ingredients of the iodin mixture onto the solution in which they are present, a soluble salt such as, sodium chloride. The salt has beenfound to be effective when, in the solution, it is present in quantity suiiicient -to attain substantially the same concentration as the concentration of salt in the blood. Such concentration in the solution has been found to impede or slow down the process of coagulation so that the iodin. mixture may .be reacted by the hydrogen ion concentration of the bacteria at the wound, with resultant separation of the sterilizing nascent iodin. A suitable accepts concentration has been eflected by using between 4 and 5 parts of sodium chloride in relation to between 3.7 to 4.2 parts of the iodin mixture.

A tabulation of these proportions for the dry ingredients, in which the proportions are given in parts by weight, reads as follows:

Parts Iodin mixture 3.7-4.2 Sodium chloride 4 -5 Disodium orthophosphate; 3 -4 Sodium bicarbonate 0.4-0.666

The solution may be made up .by taking ten parts by weight of the mixture of all the dry ingredients, and dissolving such dry ingredients in ninety parts by weight of water. 'The solution prepared in this manner may be used for antiseptic purposes without danger in relationship to any part of the body. The solution is colorless, will not stain fabrics, and does not harm the skin.

-Many other changes could be efle'cted in the particular composition, and in the proportions thereof, hereinbefore set forth, and in the method of preparation and use set forth, and in specific details thereof, without substantially departing from the invention'defined in the claims, the

specific description being merely of embodiments capable of illustrating certain principles of the invention.

What is claimed as new and useful is:

1. An antiseptic composition for the liberation I produce nascent iodin in the presence of bacteria,

the composition including a water soluble iodide,

a water soluble iodate, and means for controlling the speed of formation of iodin by the reaction of iodide and iodate including a water soluble orthophosphate which does not have an acid reaction,

all in uantities such as to produce a substantially neutral composition.

3. A composition for use as an antiseptic to produce nascent iodin in the presence ofbacteria, the composition including a water soluble iodide, a water soluble iodate, and means for controlling the speed of formation of iodin by the reaction of iodide and iodate including disodium orthophosphate in quantities such as to produce a substantially neutral composition.

1 j 4. A composition for use as an antiseptic to produce nascent iodin in the presence of bacteria. the composition including a water soluble iodide, a water soluble iodate. a water soluble orthophosphate, a water soluble, acid carbonate, and a soluble chloride, all in quantities such as to produce a substantially neutral composition.

5. A composition for use as an antiseptic to produce nascent iodin in the presence of bacteria. the composition including sodium iodide and sodium iodate in the proportion of five molecules or iodide to one molecule of iodate in such concen- ,tration in solution that the hydrogen ion concentration of a bacterial presence at a point to be treated will cause nascent iodin to be separated in proportion to the hydrogen ion concentration, and disodium orthophosphate in the proportion of between 3 to 4 parts of disodium orthophosphate to- 3.7 to 4.2 parts of the mixture of sodium iodide and sodium iodate. I

6. A composition for use as an antiseptic to produce nascent iodin in the presence of bacteria, the composition including sodium iodide and sodium iodate in balanced proportions, the iodide and the iodate being present in such quantities that estate of unstable equilibrium in the reaction to liberate nascent iodin for antiseptic purposes exists when the composition is in water solution so that nascent iodin will be separated by and in proportion. to the hydrogen ion concentration of abaoterial presence, and disodium orthophosphate and sodium bicarbonate in the proportion of between 3 to 4 parts of disodium orthophosphate to between 0.4 to 0.666 parts of sodium bicarbonate.

7. A solution for use 'as'an antiseptic to produce nascent iodin in the presence of bacteria, the solution including sodium iodide and sodium iodate in solution in the proportion of five molecules of iodide to one molecule of iodate, disodium orthophosphate in ,the proportion of between 3 to 4 parts of disodium orthophosphate tobetween 3.7 to 4.2 parts of the mixture of sodium iodide and sodium iodate, and sodium chloride, water for the solution being present in the amount of ninety parts by weight to ten parts by weight of solute. I

8. A solution for use as an antiseptic to produce nascent iodin in the presence of bacteria, the solution including sodium iodide and sodium iodate in solution in the proportion of five molecules of iodide to one molecule of iodate, and disodium orthophosphate and sodium bicarbonate in the proportion of between 3 to 4 parts of di-' sodium orthophosphate to between 0.4 to 0.666

parts of sodium bicarbonate, and between 3 to 4 M. amnion-some.