WO2006081331A3 - Quinoxaline derivatives as antitumor agents - Google Patents

Quinoxaline derivatives as antitumor agents Download PDF

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Publication number
WO2006081331A3
WO2006081331A3 PCT/US2006/002717 US2006002717W WO2006081331A3 WO 2006081331 A3 WO2006081331 A3 WO 2006081331A3 US 2006002717 W US2006002717 W US 2006002717W WO 2006081331 A3 WO2006081331 A3 WO 2006081331A3
Authority
WO
WIPO (PCT)
Prior art keywords
antitumor agents
quinoxaline derivatives
erastin
methods
binding partners
Prior art date
Application number
PCT/US2006/002717
Other languages
French (fr)
Other versions
WO2006081331A2 (en
Inventor
Robert R Becklin
Cindy Lou Chepanoske
John M Pelter
Longwu Qi
Paul B Robbins
Sudhir R Sahasrabudhe
Robert Selliah
Keith Simmons
Brent R Stockwell
Raj Gopal Venkat
Rechenberg Moritz Von
Eugene Zhen
Original Assignee
Prolexys Pharmaceuticals Inc
Whitehaed Inst For Biomedical
Univ Columbia
Robert R Becklin
Cindy Lou Chepanoske
John M Pelter
Longwu Qi
Paul B Robbins
Sudhir R Sahasrabudhe
Robert Selliah
Keith Simmons
Brent R Stockwell
Raj Gopal Venkat
Rechenberg Moritz Von
Eugene Zhen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolexys Pharmaceuticals Inc, Whitehaed Inst For Biomedical, Univ Columbia, Robert R Becklin, Cindy Lou Chepanoske, John M Pelter, Longwu Qi, Paul B Robbins, Sudhir R Sahasrabudhe, Robert Selliah, Keith Simmons, Brent R Stockwell, Raj Gopal Venkat, Rechenberg Moritz Von, Eugene Zhen filed Critical Prolexys Pharmaceuticals Inc
Priority to US11/883,092 priority Critical patent/US8518959B2/en
Priority to AU2006208084A priority patent/AU2006208084B2/en
Priority to NZ560320A priority patent/NZ560320A/en
Priority to ES06733907T priority patent/ES2409686T3/en
Priority to JP2007552406A priority patent/JP5139083B2/en
Priority to CA2595848A priority patent/CA2595848C/en
Priority to BRPI0607306-9A priority patent/BRPI0607306A2/en
Priority to EP06733907A priority patent/EP1848698B1/en
Publication of WO2006081331A2 publication Critical patent/WO2006081331A2/en
Publication of WO2006081331A3 publication Critical patent/WO2006081331A3/en
Priority to IL184788A priority patent/IL184788A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Abstract

The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3) . The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives, such like the compounds (1).
PCT/US2006/002717 2005-01-25 2006-01-25 Quinoxaline derivatives as antitumor agents WO2006081331A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US11/883,092 US8518959B2 (en) 2005-01-25 2006-01-25 Quinoxaline derivatives as antitumor agents
AU2006208084A AU2006208084B2 (en) 2005-01-25 2006-01-25 Quinoxaline Derivatives as Antitumor Agents
NZ560320A NZ560320A (en) 2005-01-25 2006-01-25 Quinoxaline derivatives as antitumor agents
ES06733907T ES2409686T3 (en) 2005-01-25 2006-01-25 Quinoxaline derivatives as antitumor agents
JP2007552406A JP5139083B2 (en) 2005-01-25 2006-01-25 Quinoxaline derivatives as antitumor agents
CA2595848A CA2595848C (en) 2005-01-25 2006-01-25 Erastin and erastin binding proteins, and uses thereof
BRPI0607306-9A BRPI0607306A2 (en) 2005-01-25 2006-01-25 quinoxaline derivatives as anti-tumor agents
EP06733907A EP1848698B1 (en) 2005-01-25 2006-01-25 Quinoxaline derivatives as antitumor agents
IL184788A IL184788A0 (en) 2005-01-25 2007-07-23 Quinoxaline derivatives as antitumor agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64730305P 2005-01-25 2005-01-25
US60/647,303 2005-01-25
US76222106P 2006-01-24 2006-01-24
US60/762,221 2006-01-24

Publications (2)

Publication Number Publication Date
WO2006081331A2 WO2006081331A2 (en) 2006-08-03
WO2006081331A3 true WO2006081331A3 (en) 2007-06-07

Family

ID=36694239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002717 WO2006081331A2 (en) 2005-01-25 2006-01-25 Quinoxaline derivatives as antitumor agents

Country Status (11)

Country Link
US (2) US8518959B2 (en)
EP (1) EP1848698B1 (en)
JP (1) JP5139083B2 (en)
KR (1) KR20080009048A (en)
AU (1) AU2006208084B2 (en)
BR (1) BRPI0607306A2 (en)
CA (1) CA2595848C (en)
ES (1) ES2409686T3 (en)
IL (1) IL184788A0 (en)
NZ (1) NZ560320A (en)
WO (1) WO2006081331A2 (en)

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DE102005027517A1 (en) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Process for the preparation of dihydroquinazolines
US8093369B2 (en) * 2005-10-11 2012-01-10 Ben Gurion University Of The Negev Research And Development Authority Ltd. Compositions for silencing the expression of VDAC1 and uses thereof
US20120164730A1 (en) * 2005-10-11 2012-06-28 Ben-Gurion University Of The Negev Research And Development Authority Ltd. Compositions for silencing the expression of vdac1 and uses thereof
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US20110123486A1 (en) * 2007-06-25 2011-05-26 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
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US9695133B2 (en) * 2012-07-13 2017-07-04 The Trustees Of Columbia University In The City Of New York Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use
US11467158B2 (en) 2012-10-29 2022-10-11 Boston Medical Center Corporation BRCA1 mutations as predictive markers for topoisomerase inhibitions
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US9580393B2 (en) 2012-12-13 2017-02-28 University Of Kansas 6-substituted quinazolinone inhibitors
TWI657085B (en) 2013-10-04 2019-04-21 英菲尼提製藥股份有限公司 Heterocyclic compounds and uses thereof
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Also Published As

Publication number Publication date
CA2595848C (en) 2014-06-17
JP5139083B2 (en) 2013-02-06
US20060211683A1 (en) 2006-09-21
ES2409686T3 (en) 2013-06-27
IL184788A0 (en) 2007-12-03
EP1848698A2 (en) 2007-10-31
EP1848698B1 (en) 2013-03-13
NZ560320A (en) 2011-02-25
US8518959B2 (en) 2013-08-27
JP2008531476A (en) 2008-08-14
CA2595848A1 (en) 2006-08-03
BRPI0607306A2 (en) 2009-08-25
AU2006208084A1 (en) 2006-08-03
AU2006208084B2 (en) 2012-07-26
US20090214465A1 (en) 2009-08-27
KR20080009048A (en) 2008-01-24
US7615554B2 (en) 2009-11-10
WO2006081331A2 (en) 2006-08-03

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