WO2006081331A3 - Quinoxaline derivatives as antitumor agents - Google Patents
Quinoxaline derivatives as antitumor agents Download PDFInfo
- Publication number
- WO2006081331A3 WO2006081331A3 PCT/US2006/002717 US2006002717W WO2006081331A3 WO 2006081331 A3 WO2006081331 A3 WO 2006081331A3 US 2006002717 W US2006002717 W US 2006002717W WO 2006081331 A3 WO2006081331 A3 WO 2006081331A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antitumor agents
- quinoxaline derivatives
- erastin
- methods
- binding partners
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES06733907T ES2409686T3 (en) | 2005-01-25 | 2006-01-25 | Quinoxaline derivatives as antitumor agents |
JP2007552406A JP5139083B2 (en) | 2005-01-25 | 2006-01-25 | Quinoxaline derivatives as antitumor agents |
EP06733907A EP1848698B1 (en) | 2005-01-25 | 2006-01-25 | Quinoxaline derivatives as antitumor agents |
NZ560320A NZ560320A (en) | 2005-01-25 | 2006-01-25 | Quinoxaline derivatives as antitumor agents |
BRPI0607306-9A BRPI0607306A2 (en) | 2005-01-25 | 2006-01-25 | quinoxaline derivatives as anti-tumor agents |
US11/883,092 US8518959B2 (en) | 2005-01-25 | 2006-01-25 | Quinoxaline derivatives as antitumor agents |
AU2006208084A AU2006208084B2 (en) | 2005-01-25 | 2006-01-25 | Quinoxaline Derivatives as Antitumor Agents |
CA2595848A CA2595848C (en) | 2005-01-25 | 2006-01-25 | Erastin and erastin binding proteins, and uses thereof |
IL184788A IL184788A0 (en) | 2005-01-25 | 2007-07-23 | Quinoxaline derivatives as antitumor agents |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64730305P | 2005-01-25 | 2005-01-25 | |
US60/647,303 | 2005-01-25 | ||
US76222106P | 2006-01-24 | 2006-01-24 | |
US60/762,221 | 2006-01-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006081331A2 WO2006081331A2 (en) | 2006-08-03 |
WO2006081331A3 true WO2006081331A3 (en) | 2007-06-07 |
Family
ID=36694239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/002717 WO2006081331A2 (en) | 2005-01-25 | 2006-01-25 | Quinoxaline derivatives as antitumor agents |
Country Status (11)
Country | Link |
---|---|
US (2) | US8518959B2 (en) |
EP (1) | EP1848698B1 (en) |
JP (1) | JP5139083B2 (en) |
KR (1) | KR20080009048A (en) |
AU (1) | AU2006208084B2 (en) |
BR (1) | BRPI0607306A2 (en) |
CA (1) | CA2595848C (en) |
ES (1) | ES2409686T3 (en) |
IL (1) | IL184788A0 (en) |
NZ (1) | NZ560320A (en) |
WO (1) | WO2006081331A2 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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DE10319612A1 (en) * | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituted dihydroquinazolines |
DE10320780A1 (en) * | 2003-05-09 | 2005-01-20 | Bayer Healthcare Ag | Heterocyclyl-substituted dihydroquinazolines |
DE10352499A1 (en) * | 2003-11-11 | 2005-06-09 | Bayer Healthcare Ag | Substituted dihydroquinazolines II |
DE102004022672A1 (en) * | 2004-05-07 | 2005-11-24 | Bayer Healthcare Ag | Substituted azachinazolines |
JP2008537726A (en) * | 2005-01-25 | 2008-09-25 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | Elastin analogues and their use for killing cancer cells |
ES2409686T3 (en) | 2005-01-25 | 2013-06-27 | Prolexys Pharmaceuticals, Inc. | Quinoxaline derivatives as antitumor agents |
DE102005027517A1 (en) * | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Process for the preparation of dihydroquinazolines |
US20120164730A1 (en) * | 2005-10-11 | 2012-06-28 | Ben-Gurion University Of The Negev Research And Development Authority Ltd. | Compositions for silencing the expression of vdac1 and uses thereof |
EP1934348B1 (en) * | 2005-10-11 | 2018-05-02 | Ben-Gurion University Of The Negev Research And Development Authority | Compositions for silencing the expression of vdac1 and uses thereof |
AU2006330883A1 (en) * | 2005-12-22 | 2007-07-05 | Prolexys Pharmaceuticals, Inc. | 3-aryl-substituted quinazolones, and uses thereof |
WO2007076085A2 (en) * | 2005-12-22 | 2007-07-05 | Prolexys Pharmaceuticals, Inc . | Fused pyrimidones and thiopyrimidones, and uses thereof |
WO2008013987A2 (en) * | 2006-07-27 | 2008-01-31 | Prolexys Pharmaceuticals, Inc. | N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones |
US20110123486A1 (en) * | 2007-06-25 | 2011-05-26 | Prolexys Pharmaceuticals, Inc. | Methods of treating multiple myeloma and resistant cancers |
EP2269072B1 (en) | 2008-03-31 | 2017-08-23 | Boston Medical Center Corporation | Predictive marker for topoisomerase i inhibitors |
WO2011078226A1 (en) * | 2009-12-22 | 2011-06-30 | 協和発酵キリン株式会社 | Tricyclic compound |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2014011973A2 (en) * | 2012-07-13 | 2014-01-16 | The Trustees Of Columbia University In The City Of New York | Quinazolinone-based oncogenic-ras-selective lethal compounds and their use |
US11467158B2 (en) | 2012-10-29 | 2022-10-11 | Boston Medical Center Corporation | BRCA1 mutations as predictive markers for topoisomerase inhibitions |
CN103360327B (en) * | 2012-12-13 | 2016-04-20 | 中山大学 | A kind of phenonaphthazine derivative and its preparation method and application |
US9580393B2 (en) | 2012-12-13 | 2017-02-28 | University Of Kansas | 6-substituted quinazolinone inhibitors |
PE20160685A1 (en) | 2013-10-04 | 2016-07-23 | Infinity Pharmaceuticals Inc | HETEROCYCLIC COMPOUNDS AND USES OF THEM |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2015109009A1 (en) * | 2014-01-15 | 2015-07-23 | The Trustees Of Columbia University In The City Of New York | Carbonyl erastin analogs and their use |
JP6701088B2 (en) | 2014-03-19 | 2020-05-27 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders |
CN106459011B (en) * | 2014-04-01 | 2019-11-15 | 华盛顿大学 | σ -2 receptors ligand drug conjugate, its preparation method and use as antitumoral compounds |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
US9708359B2 (en) | 2015-08-06 | 2017-07-18 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof |
CA2998469A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
EP3373939A4 (en) | 2015-11-10 | 2019-06-26 | B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University | Means and methods for reducing tumorigenicity of cancer stem cells |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US11111264B2 (en) | 2017-09-21 | 2021-09-07 | Chimerix, Inc. | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof |
MA52897A (en) | 2018-06-15 | 2021-04-21 | Flagship Pioneering Innovations V Inc | REDUCTION OF IMMUNE ACTIVITY BY MODULATION OF POST-CELLULAR SIGNALING FACTORS |
KR20210035805A (en) | 2018-06-15 | 2021-04-01 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | Increased immune activity through regulation of postcellular signaling factors |
WO2021050490A1 (en) * | 2019-09-13 | 2021-03-18 | The Trustees Of Columbia University In The City Of New York | Methods of enhancing radiotherapy using ferroptosis inducers as radiosensitizers |
WO2021127217A1 (en) | 2019-12-17 | 2021-06-24 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
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-
2006
- 2006-01-25 ES ES06733907T patent/ES2409686T3/en active Active
- 2006-01-25 NZ NZ560320A patent/NZ560320A/en not_active IP Right Cessation
- 2006-01-25 AU AU2006208084A patent/AU2006208084B2/en not_active Ceased
- 2006-01-25 US US11/883,092 patent/US8518959B2/en not_active Expired - Fee Related
- 2006-01-25 JP JP2007552406A patent/JP5139083B2/en not_active Expired - Fee Related
- 2006-01-25 WO PCT/US2006/002717 patent/WO2006081331A2/en active Search and Examination
- 2006-01-25 US US11/340,430 patent/US7615554B2/en not_active Expired - Fee Related
- 2006-01-25 BR BRPI0607306-9A patent/BRPI0607306A2/en not_active IP Right Cessation
- 2006-01-25 KR KR1020077019501A patent/KR20080009048A/en not_active Application Discontinuation
- 2006-01-25 CA CA2595848A patent/CA2595848C/en not_active Expired - Fee Related
- 2006-01-25 EP EP06733907A patent/EP1848698B1/en not_active Not-in-force
-
2007
- 2007-07-23 IL IL184788A patent/IL184788A0/en unknown
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Also Published As
Publication number | Publication date |
---|---|
US8518959B2 (en) | 2013-08-27 |
CA2595848C (en) | 2014-06-17 |
JP5139083B2 (en) | 2013-02-06 |
AU2006208084A1 (en) | 2006-08-03 |
IL184788A0 (en) | 2007-12-03 |
KR20080009048A (en) | 2008-01-24 |
US20090214465A1 (en) | 2009-08-27 |
AU2006208084B2 (en) | 2012-07-26 |
US7615554B2 (en) | 2009-11-10 |
WO2006081331A2 (en) | 2006-08-03 |
ES2409686T3 (en) | 2013-06-27 |
BRPI0607306A2 (en) | 2009-08-25 |
EP1848698A2 (en) | 2007-10-31 |
US20060211683A1 (en) | 2006-09-21 |
JP2008531476A (en) | 2008-08-14 |
NZ560320A (en) | 2011-02-25 |
EP1848698B1 (en) | 2013-03-13 |
CA2595848A1 (en) | 2006-08-03 |
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