WO2011075614A3 - Portable coagulation monitoring device and method of assessing coagulation response - Google Patents

Portable coagulation monitoring device and method of assessing coagulation response Download PDF

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Publication number
WO2011075614A3
WO2011075614A3 PCT/US2010/060911 US2010060911W WO2011075614A3 WO 2011075614 A3 WO2011075614 A3 WO 2011075614A3 US 2010060911 W US2010060911 W US 2010060911W WO 2011075614 A3 WO2011075614 A3 WO 2011075614A3
Authority
WO
WIPO (PCT)
Prior art keywords
coagulation
planar surfaces
response
monitoring device
assessing
Prior art date
Application number
PCT/US2010/060911
Other languages
French (fr)
Other versions
WO2011075614A2 (en
Inventor
Robert Glenn Dennis
Thomas H. Fischer
Joseph A. Dacorta
Original Assignee
Entegrion, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP20100838275 priority Critical patent/EP2513647B1/en
Priority to CA2780492A priority patent/CA2780492C/en
Priority to CN201080055503.9A priority patent/CN102687009B/en
Priority to MX2012007084A priority patent/MX2012007084A/en
Priority to JP2012544860A priority patent/JP5655091B2/en
Priority to BR112012014421A priority patent/BR112012014421B8/en
Application filed by Entegrion, Inc. filed Critical Entegrion, Inc.
Priority to ES10838275.5T priority patent/ES2543099T3/en
Priority to AU2010330861A priority patent/AU2010330861B2/en
Publication of WO2011075614A2 publication Critical patent/WO2011075614A2/en
Publication of WO2011075614A3 publication Critical patent/WO2011075614A3/en
Priority to ECSP12011981 priority patent/ECSP12011981A/en
Priority to HK13100873.7A priority patent/HK1173497A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N2011/006—Determining flow properties indirectly by measuring other parameters of the system
    • G01N2011/008—Determining flow properties indirectly by measuring other parameters of the system optical properties

Abstract

A device, system and method is disclosed in which small volume blood samples are subjected to shear forces and shear stresses between two parallel planar surfaces to which linear motion trajectories are imparted. The formation of clots or coagulation of the sample is measured from dynamic mechanical coupling which occurs between the two parallel planar surfaces. Detection of the coagulation response can be achieved through optical probing or by measurement of physical effects of the blood sample binding to the planar surfaces, and restricting movement thereof.
PCT/US2010/060911 2009-12-18 2010-12-17 Portable coagulation monitoring device and method of assessing coagulation response WO2011075614A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA2780492A CA2780492C (en) 2009-12-18 2010-12-17 Portable coagulation monitoring device and method of assessing coagulation response
CN201080055503.9A CN102687009B (en) 2009-12-18 2010-12-17 Portable coagulation monitoring device and method of assessing coagulation response
MX2012007084A MX2012007084A (en) 2009-12-18 2010-12-17 Portable coagulation monitoring device and method of assessing coagulation response.
JP2012544860A JP5655091B2 (en) 2009-12-18 2010-12-17 Portable blood coagulation monitoring device and evaluation method of blood coagulation reaction
BR112012014421A BR112012014421B8 (en) 2009-12-18 2010-12-17 device for measuring clotting response in a blood sample
EP20100838275 EP2513647B1 (en) 2009-12-18 2010-12-17 Portable coagulation monitoring device and method of assessing coagulation response
ES10838275.5T ES2543099T3 (en) 2009-12-18 2010-12-17 Portable coagulation monitoring device and method for assessing coagulation response
AU2010330861A AU2010330861B2 (en) 2009-12-18 2010-12-17 Portable coagulation monitoring device and method of assessing coagulation response
ECSP12011981 ECSP12011981A (en) 2009-12-18 2012-06-18 PORTABLE DEVICE FOR COAGULATION MONITORING AND EVALUATION METHOD OF THE COAGULATION RESPONSE
HK13100873.7A HK1173497A1 (en) 2009-12-18 2013-01-21 Portable coagulation monitoring device and method of assessing coagulation response

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28778009P 2009-12-18 2009-12-18
US61/287,780 2009-12-18

Publications (2)

Publication Number Publication Date
WO2011075614A2 WO2011075614A2 (en) 2011-06-23
WO2011075614A3 true WO2011075614A3 (en) 2011-10-13

Family

ID=44151642

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/060911 WO2011075614A2 (en) 2009-12-18 2010-12-17 Portable coagulation monitoring device and method of assessing coagulation response

Country Status (17)

Country Link
US (2) US8450078B2 (en)
EP (1) EP2513647B1 (en)
JP (1) JP5655091B2 (en)
CN (1) CN102687009B (en)
AU (1) AU2010330861B2 (en)
BR (1) BR112012014421B8 (en)
CA (1) CA2780492C (en)
CO (1) CO6551732A2 (en)
CR (1) CR20120326A (en)
EC (1) ECSP12011981A (en)
ES (1) ES2543099T3 (en)
HK (1) HK1173497A1 (en)
HN (1) HN2012001269A (en)
MX (1) MX2012007084A (en)
NI (1) NI201200109A (en)
PE (1) PE20121723A1 (en)
WO (1) WO2011075614A2 (en)

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US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US10739358B2 (en) 2009-12-18 2020-08-11 Entegrion, Inc. Portable coagulation monitoring devices, systems, and methods
DK2555704T3 (en) 2010-04-08 2019-08-05 Hemosonics Llc VIEW OF HEMOSTATIC PARAMETERS
US20140083628A1 (en) 2012-09-27 2014-03-27 Velico Medical, Inc. Spray drier assembly for automated spray drying
US9272280B2 (en) 2011-02-15 2016-03-01 Hemosonics Llc Device, systems and methods for evaluation of hemostasis
EP2676143B1 (en) 2011-02-15 2023-11-01 Hemosonics, Llc Characterization of blood hemostasis and oxygen transport parameters
WO2012159021A2 (en) 2011-05-19 2012-11-22 Hemosonics, Llc Portable hemostasis analyzer
WO2013099238A1 (en) * 2011-12-26 2013-07-04 パナソニック株式会社 Liquid sample measuring system and measuring device
JP2015503767A (en) 2012-01-16 2015-02-02 エイブラム サイエンティフィック，インコーポレーテッド Methods, devices and systems for measuring physical properties of fluids
WO2014085804A1 (en) 2012-11-30 2014-06-05 The University Of North Carolina At Chapel Hill Methods, systems, and computer readable media for determining physical properties of a specimen in a portable point of care diagnostic device
EP2932260B1 (en) 2012-12-17 2019-05-01 Abbott Point Of Care Inc Operation and verification of a portable clinical analysis system
WO2014099419A1 (en) 2012-12-17 2014-06-26 Abbott Point Of Care Inc A portable clinical analysis system for hematocrit measurement
US9494578B2 (en) 2012-12-17 2016-11-15 Abbott Point Of Care Inc. Spatial orientation determination in portable clinical analysis systems
US9885706B2 (en) 2012-12-17 2018-02-06 Abbott Point Of Care Inc. Portable clinical analysis system for immunometric measurement
US9904761B2 (en) 2012-12-17 2018-02-27 Abbot Point Of Care Inc. Self correction for spatial orientation and motion of portable clinical analyzers
KR101481240B1 (en) * 2012-12-27 2015-01-19 고려대학교 산학협력단 Apparatus and method for monitoring platelet function and drug response in a microfluidic-chip
CN103487377B (en) * 2013-10-11 2016-03-09 江苏英诺华医疗技术有限公司 A kind of detector for coagulation function of whole blood and detection method
US10823743B1 (en) * 2013-10-28 2020-11-03 Ifirst Medical Technologies, Inc. Methods of measuring coagulation of a biological sample
EP3069135A4 (en) * 2013-11-15 2017-08-30 Entegrion, Inc. Portable coagulation monitoring devices, systems, and methods
US9452199B2 (en) * 2014-01-17 2016-09-27 General Electric Company Platelet activation and growth factor release using electric pulses
EP3140650B1 (en) 2014-05-05 2022-07-20 Haemonetics Corporation Methodologies and reagents for detecting fibrinolysis and hyperfibrinolysis
EP3191836B1 (en) * 2014-09-09 2022-11-23 Perosphere Technologies Inc. Microfluid chip-based, universal coagulation assay
US9561184B2 (en) 2014-09-19 2017-02-07 Velico Medical, Inc. Methods and systems for multi-stage drying of plasma
US10175225B2 (en) 2014-09-29 2019-01-08 C A Casyso Ag Blood testing system and method
WO2016077657A1 (en) * 2014-11-14 2016-05-19 Cora Healthcare, Inc. Apparatus and method to determine stroke subtype
US9726647B2 (en) 2015-03-17 2017-08-08 Hemosonics, Llc Determining mechanical properties via ultrasound-induced resonance
CN105403691B (en) * 2016-01-01 2017-08-18 赛奥生物科技（青岛）有限公司 A kind of Blood Kit analysis system
CN106198943B (en) * 2016-08-16 2019-11-12 中国科学院苏州生物医学工程技术研究所 A kind of Studies on Hemodynamic Changes device
GB2555870A (en) 2016-11-15 2018-05-16 Haemair Ltd Rheometer and method for the use thereof
US11596948B2 (en) * 2016-11-17 2023-03-07 Enicor Gmbh Coated articles for blood coagulation testing and methods of preparing the same
CA3065331A1 (en) 2017-04-20 2018-10-25 Hemosonics, Llc Disposable system for analysis of hemostatic function
EP3830573A4 (en) * 2018-07-29 2022-02-23 KOC Universitesi Microfluidic thromboelastometry instrument
US20210260589A1 (en) * 2020-02-26 2021-08-26 Emmanuel Mpock Method and Apparatus for Measuring Blood Coagulation
KR102414376B1 (en) * 2020-05-26 2022-06-29 고려대학교 산학협력단 Blood test apparatus
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system

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US20040175296A1 (en) * 1999-11-15 2004-09-09 Opalsky Cindra A. Widrig Apparatus and method for assaying coagulation in fluid samples
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Patent Citations (5)

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US5181415A (en) * 1990-07-20 1993-01-26 Serbio Apparatus for detecting a change of viscosity by measuring a relative slip, in particular for detecting the coagulation rate of blood
US20040175296A1 (en) * 1999-11-15 2004-09-09 Opalsky Cindra A. Widrig Apparatus and method for assaying coagulation in fluid samples
US7074582B2 (en) * 2000-10-27 2006-07-11 Biomerieux, Inc. Method for assessing coagulation
US7361306B2 (en) * 2002-04-18 2008-04-22 Antonio Bote Bote Device and method for measuring coagulation time and platelet activity
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method

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Also Published As

Publication number Publication date
HN2012001269A (en) 2014-12-01
BR112012014421B1 (en) 2021-02-02
HK1173497A1 (en) 2013-05-16
EP2513647A2 (en) 2012-10-24
AU2010330861A1 (en) 2012-05-31
BR112012014421B8 (en) 2021-07-27
EP2513647B1 (en) 2015-04-22
EP2513647A4 (en) 2013-09-04
PE20121723A1 (en) 2012-12-11
CN102687009B (en) 2014-07-16
CO6551732A2 (en) 2012-10-31
NI201200109A (en) 2013-02-15
CR20120326A (en) 2012-09-24
US9063161B2 (en) 2015-06-23
ECSP12011981A (en) 2012-08-31
CA2780492A1 (en) 2011-06-23
WO2011075614A2 (en) 2011-06-23
JP2013515238A (en) 2013-05-02
US20110151491A1 (en) 2011-06-23
JP5655091B2 (en) 2015-01-14
CA2780492C (en) 2018-07-17
US20130267017A1 (en) 2013-10-10
CN102687009A (en) 2012-09-19
ES2543099T3 (en) 2015-08-14
US8450078B2 (en) 2013-05-28
BR112012014421A2 (en) 2017-12-19
AU2010330861B2 (en) 2013-09-26
MX2012007084A (en) 2012-10-15

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